A5000381629- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Biological Research and Disease Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Synthesis and Biological Evaluation
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Gastroesophageal reflux and treatments
Albert Einstein College of Medicine
2024
Universidade Estadual de Campinas (UNICAMP)
2021-2023
Universidade Federal do Paraná
2018-2022
The University of Texas MD Anderson Cancer Center
2018-2021
Universidade Federal do Triângulo Mineiro
2016
KRAS is one of the most frequently mutated proto-oncogenes in pancreatic ductal adenocarcinoma (PDAC) and aberrantly activated triple-negative breast cancer (TNBC). A profound role microRNAs (miRNAs) pathogenesis human being uncovered, including therapy. Using silico prediction algorithms, we identified miR-873 as a potential regulator KRAS, investigated its PDAC TNBC. We found that reduced expression associated with shorter patient survival both cancers. significantly repressed TNBC cell...
Abstract Prostate cancer (PCa) represents the second most common in men and affects millions worldwide. Chemotherapy is a treatment for PCa but development of resistance often problem during therapy. NRF2 (nuclear factor erythroid 2‐related 2) one major transcription factors regulating antioxidant enzymes also involved with drug efflux detoxification. Cancer cells submitted to chemotherapy promote activation benefit themselves cytoprotective response. Here, we found that DU145 PC3 cell lines...
The human genome contains 481 ultraconserved regions (UCRs), which are genomic stretches of over 200 base pairs conserved among human, rat, and mouse. majority these transcriptionally active (T-UCRs), several have been found to be differentially expressed in tumours. Some T-UCRs functionally characterized, but those few associated breast cancer (BC). Using TCGA data, we 302 related clinical features BC: 43% were with molecular subtypes, 36% oestrogen-receptor positivity, 17% HER2 expression,...
SARS-CoV-2 is an emerging virus from the Coronaviridae family and responsible for ongoing COVID-19 pandemic. In this work, we explored previously reported structural membrane protein (M) interaction with human Proliferating Cell Nuclear Antigen (PCNA). The M maintaining virion shape, PCNA a marker of DNA damage which essential replication repair. We validated M-PCNA through immunoprecipitation, immunofluorescence co-localization, PLA (Proximity Ligation Assay). cells infected or transfected...
Lnc-uc.147, a long non-coding RNA derived from transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this other tumor types not investigated. The present study aimed to investigate lnc-uc.147 different cancer, as well suggest functional and regulation aspects. From solid datasets analysis Cancer Genome Atlas (TCGA), deregulated expression associated with histologic grade hepatocellular carcinoma, stage clear cell renal gastric...
Long non-coding RNAs (lncRNAs) are functional transcripts with more than 200 nucleotides. These molecules exhibit great regulatory capacity and may act at different levels of gene expression regulation. Despite this versatility, the biology these is still poorly understood. Computational approaches being increasingly used to elucidate biological mechanisms in which lncRNAs be involved. Co-expression networks can serve as allies elucidating possible contexts Herein, we propose use pipeline...
Ultraconserved regions (UCRs) are 481 genome segments, with length longer than 200 bp, that 100% conserved among humans, mice, and rats. The majority of UCRs transcriptionally active (T-UCRs) as many them produce non-coding RNAs. In a previous study, we evaluated the expression level T-UCRs in breast cancer (BC) patients found 63% transcripts correlated some clinical and/or molecular parameter BC. this delved into levels 12 clinicopathological parameters, immunohistochemical markers, overall...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy due to overwhelming metastatic burden. PDAC cells migrate and invade by two distinct epithelial-to-mesenchymal transition phenotypes: collective (partial-EMT) or single-cell (complete-EMT). The mechanism(s) which these invasive phenotypes intravasate unknown. Tumor Microenvironment of Metastasis (TMEM) doorway, formed tumor cell, macrophage an endothelial cell in direct contact, causes opening the vasculature...
Introduction: Long non-coding RNAs (LncRNA) represent a heterogeneous family of that have emerged as regulators various biological processes through their association with proteins in ribonucleoproteins complexes. The dynamic these interactions can affect cell metabolism, including cancer development. Annually, breast causes thousands deaths worldwide, and searching for new biomarkers is pivotal better diagnosis treatment. Methods: Based on silico prediction analysis, we focus LncRNAs...
Obesity is associated with low-grade inflammation and disturbances in hepatic metabolism. This study aimed to investigate the effects of resistance exercise on inflammatory signalling related IκB kinase (IKK) ɛ protein (IKKɛ) fat accumulation obese mice. Male Swiss mice were distributed into three groups: control (CTL) fed standard chow; (OB) induced by a high-fat diet (HFD); exercised (OB + RE) HFD submitted training. The training protocol consisted 20 sets/3 ladder climbs for 8 weeks,...
Abstract The COVID-19 disease caued by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has two characteristics that distinguish it from other viral infections. It affects more severely people with pre-existing comorbidities and load peaks prior to onset of symptoms. Investigating factors could contribute these characteristics, we found increased mTOR signaling suppressed genes related autophagy, lysosome, vesicle fusion in Vero E6 cells infected SARS-CoV-2. Transcriptomic...
ABSTRACT SARS-CoV-2 is an emerging virus from the Coronaviridae family and responsible for ongoing COVID-19 pandemic. In this work, we explored previously reported structural membrane protein (M) interaction with human Proliferating Cell Nuclear Antigen (PCNA). The M maintaining virion shape, PCNA a marker of DNA damage which essential replication repair. We validated through immunoprecipitation, immunofluorescence co-localization, PLA assay. cells infected or transfected protein, using cell...
Introduction: Long RNAs are non-coding with more than 200 nucleotides in length, essential regulatory roles several biological processes, including breast cancer (BC). The human genome contains 481 ultraconserved regions, which genomic stretches of over base pairs conserved among humans, rats, and mice. Most these regions transcriptionally active (T-UCRs), differentially expressed tumors. Some T-UCRs have been functionally characterized, but few associated BC. Objectives: In this study, we...
O câncer de mama é a neoplasia mais frequente entre as mulheres, excluindo os tumores pele não melanoma e compreende um grupo heterogêneo doenças, resultando em prognósticos respostas clínicas distintas. Atualmente, são classificados cinco grupos, acordo com o padrão expressão gênica, sendo eles: Luminal A, B, Basal “normal-like” HER2+. Apesar da classificação, ainda há uma dificuldade na sua utilização prática clínica. Desta forma, identificação validação novos marcadores moleculares...