A5076539388- Neuroscience and Neural Engineering
- Diversity and Career in Medicine
- Medical Education and Admissions
- Innovations in Medical Education
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Retinal Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Primary Care and Health Outcomes
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- Retinal and Optic Conditions
- Lung Cancer Diagnosis and Treatment
- Ophthalmology and Visual Health Research
- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Advanced Neuroimaging Techniques and Applications
- Pluripotent Stem Cells Research
- Nursing Diagnosis and Documentation
- 3D Printing in Biomedical Research
- Older Adults Driving Studies
- Extracellular vesicles in disease
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Cells and Metastasis
- Infectious Encephalopathies and Encephalitis
Stanford University
2019-2022
NHS Lothian
2022
Stanford Health Care
2021
Lucile Packard Children's Hospital
2020
University of California, Irvine
2017-2019
Changi General Hospital
2014
University Health Network
2009
The development of chemotherapy drug resistance remains a significant barrier for effective therapy in several cancers including breast cancer. Bone marrow-derived mesenchymal stem cells (BMMSCs) have previously been shown to influence tumor progression and the chemoresistance. In present study, we showed that when GFP labelled BMMSCs RFP HCC1806 are injected together vivo, they create tumors which contain new hybrid cell has characteristics both cells. By labelling these prior their...
<h3>Importance</h3> An end-to-end efficacy evaluation approach for identifying progression risk after epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) therapy in patients with stage IV<i>EGFR</i>variant–positive non–small cell lung cancer (NSCLC) is lacking. <h3>Objective</h3> To propose a clinically applicable large-scale bidirectional generative adversarial network predicting the of EGFR-TKI NSCLC. <h3>Design, Setting, and Participants</h3> This diagnostic/prognostic...
Epidemiological studies indicate a link between obsessive-compulsive disorder and infections, particularly streptococcal pharyngitis. Pediatric acute-onset neuropsychiatric syndrome (PANS) manifests suddenly with obsessions, compulsions, other behavioral disturbances, often after an infectious trigger. The current working model suggests unifying inflammatory process involving the central nervous system, basal ganglia.To investigate whether diffusion-weighted magnetic resonance imaging (DWI)...
Over 1250 mutations in SCN1A, the Nav1.1 voltage-gated sodium channel gene, are associated with seizure disorders including GEFS+. To evaluate how a specific mutation, independent of genetic background, causes activity we generated two pairs isogenic human iPSC lines by CRISPR/Cas9 gene editing. One pair is control line from an unaffected sibling, and mutated carrying GEFS+ K1270T SCN1A mutation. The second patient corrected line. By comparing electrophysiological properties inhibitory...
Differentiation between tumor and radiation necrosis in patients with brain metastases treated stereotactic radiosurgery is challenging. We hypothesized that MR perfusion metabolic metrics can differentiate from progressive this setting.We retrospectively evaluated MRIs comprising DSC, dynamic contrast-enhanced, arterial spin-labeling imaging subjects previously radiosurgery. For each lesion, we obtained the mean normalized standardized relative CBV fractional burden, volume transfer...
The use of human induced pluripotent stem cell (hiPSC)-derived neuronal cultures to study the mechanisms neurological disorders is often limited by low efficiency and high variability in differentiation functional neurons. Here we compare properties neurons prepared with two hiPSC protocols, both plated on astroglial feeder layers. Using a protocol an expandable intermediate stage, only small percentage cells morphology were excitable 21-23days culture. In contrast, direct strategy same line...
Sensorineural hearing loss (SNHL) is the most prevalent congenital sensory deficit in children. Information regarding underlying brain microstructure could offer insight into neural development deaf children and potentially guide therapies that optimize language development. We sought to quantitatively evaluate MRI-based cerebral volume gray matter with SNHL. conducted a retrospective study of SNHL who obtained MRI at 3 T. The cohort comprised 63 without known focal lesion or structural...
Background Iron oxide nanoparticles are an alternative contrast agent for MRI. Gadolinium deposition has raised safety concerns, but it is unknown whether ferumoxytol administration also deposits in the brain. Purpose To investigate there signal intensity changes brain at multiecho gradient imaging following exposure children and young adults. Materials Methods This retrospective case-control study included adults, matched age sex, with arteriovenous malformations who received least one dose...
Abstract We have previously demonstrated that expression of the Notch ligand, JAG1 is associated with basal breast cancer phenotype and disease recurrence. Herein we report on a genomics approach to elucidate mechanisms downstream promote growth. In survey 46 cell lines found triple negative (TN; mesenchymal ER-, PR- Her2-negative) express at significantly higher levels than do HER2+ or luminal (ER+) Her2- lines. The TN HCC1143 MDA MB231, which demonstrate growth inhibition RNA...
Children with neurofibromatosis type 1 (NF1) often report cognitive challenges, though the etiology of such remains an area active investigation. With advent treatments that may affect white matter microstructure, understanding effects age on aberrancies in NF1 becomes crucial determining timing therapeutic interventions. A cross-sectional study was performed diffusion tensor imaging from 18 children and 26 age-matched controls. Fractional anisotropy determined by region interest analyses...
Clinical research is often time-consuming and difficult to conduct in busy academic institutions. Previous studies have proposed methods integrate undergraduate students as a means increase productivity. The authors aimed describe the possibility enhance emergency department productivity at an United States, using Emergency Medicine Research Associates Program.The described Program curriculum its implementation. We also conducted retrospective study university-based from January 2005...
Abstract Over 1250 mutations in SCN1A , the Nav1.1 voltage-gated sodium channel gene, are associated with seizure disorders including GEFS+. To evaluate how a specific mutation, independent of genetic background, causes activity we generated two pairs isogenic human iPSC lines by CRISPR/Cas9 gene editing. One pair is control line from an unaffected sibling, and mutated carrying GEFS+ K1270T mutation. The second patient corrected line. By comparing electrophysiological properties inhibitory...
Health systems across the world are facing a growing challenge of providing eye care for their populations. The prevalence conditions which can lead to visual impairments in projected increase, from 596 million people with distance vision impairment 2020, 895 2050 [1]. However over 90% those affected have treatable or preventable cause, and primarily found low middle-income countries.
Background: Falls among inpatients remains one of the most commonly reported adverse events in acute care facilities, and older adults are more prone to injurious falls. At Changi General Hospital, fall precaution measures communicated patients caregivers during their admission briefing wards. It has been a challenge getting understand risks falls comply with as these often have limited attention span, poor memory recollection or impaired cognitive abilities due ageing process. Objectives:...
Abstract BACKGROUND Neurofibromatosis Type 1 (NF1) is a multisystem disorder with wide ranging clinical implications. Patients may present macrocephaly, stroke, and cognitive deficits, all of which impede normal neural development. We applied atlas-based, multi-parametric MRI analysis regional brain to evaluate diffusion, arterial spin-labeled (ASL) perfusion, volumetric changes in children NF1. METHODS Children evaluated for NF1 from 2009 2018 at Stanford University (n=78) were...
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Background Glaucoma is one of the most common ophthalmic conditions encountered in primary and secondary care. has potential to impair driving. This audit aims investigate how well we are giving driving advice patients setting United Kingdom (UK). Methods Two junior doctors interviewed all glaucoma who attended clinic 4-week period on whether they had received regarding Patients never drove did not respond were excluded from analysis Results Of 110 patients, found that only 29% recalled...
The Covid-19 pandemic has led to an increased interest in the mental health and wellbeing of doctors. Traditionally, doctors have been viewed as being immune problems, however it become evident that they are actually at risk suicide compared most other professions. In times Covid-19, frontline healthcare workers considered be a much higher for conditions, due combination infection, greater responsibilities excess workload [1].
The Covid-19 pandemic disrupted higher education across the UK, resulting in cancellation of exams and an uptake distance learning. Medical particular was faced with pressures sustaining teaching during these difficult periods, for medical students all year groups [1].