A5031583168- Extracellular vesicles in disease
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Ultrasound and Hyperthermia Applications
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Proteoglycans and glycosaminoglycans research
- Osteoarthritis Treatment and Mechanisms
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- COVID-19 and healthcare impacts
- Seaweed-derived Bioactive Compounds
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Cardiac, Anesthesia and Surgical Outcomes
- Knee injuries and reconstruction techniques
- Thermal Regulation in Medicine
- Circular RNAs in diseases
- Biological Research and Disease Studies
Huazhong Agricultural University
2024-2025
Stanford University
2018-2024
PhysioGenix (United States)
2024
Jinnah Medical & Dental College
2023
Khyber Teaching Hospital
2023
Institute of Infection and Immunity
2021-2022
Ayub Medical College
2021-2022
Abbott (Canada)
2022
California Institute for Regenerative Medicine
2022
Bangladesh University of Engineering and Technology
2021
Patients with breast cancer often develop malignant regrowth of residual drug-resistant dormant tumor cells years after primary treatment, a process defined as relapse. Deciphering the causal basis dormancy therefore has obvious therapeutic significance. Because cell behavior is strongly influenced by stromal cells, particularly mesenchymal stem/stromal (MSCs) that are actively recruited into tumor-associated stroma, we assessed impact MSCs on (BCC) dormancy. Using 3D cocultures to mimic...
Rationale: Cardiac aging is an important contributing factor for heart failure, which affects a large population but remains poorly understood. Objective: The purpose of this study to investigate whether Klotho plays role in cardiac aging. Methods and Results: Heart function declined old mice (24 months), as evidenced by decreases fractional shortening, ejection fraction, output. size weight, cardiomyocyte size, fibrosis were increased mice, indicating that causes hypertrophy remodeling....
ABSTRACT The prevalence of arterial stiffness and hypertension increases with age. This study investigates the effect induced pluripotent mesenchymal stem cell‐derived extracellular vesicles (EVs) on ageing‐associated hypertension. EVs were collected purified from cells (iPS‐MSCs). Young old male C57BL/6 mice used. Mice in group injected via tail vein once a week for four weeks (18 x 10 6 EVs/mouse/injection). Blood pressure (BP) was measured using tail‐cuff method validated by direct...
Understanding the effect of molecular pathways involved in age-dependent deterioration stem cell function is critical for developing new therapies. The overexpression Klotho (KL), an antiaging protein, causes treated animal models to enjoy extended life spans. Now, question stands: Does KL deficiency accelerate aging and telomere shortening? If so, what are specific mechanisms by which it does this, cycloastragenol (CAG) treatment enough restore telomerase activity aged cells? We found that...
The development of chemotherapy drug resistance remains a significant barrier for effective therapy in several cancers including breast cancer. Bone marrow-derived mesenchymal stem cells (BMMSCs) have previously been shown to influence tumor progression and the chemoresistance. In present study, we showed that when GFP labelled BMMSCs RFP HCC1806 are injected together vivo, they create tumors which contain new hybrid cell has characteristics both cells. By labelling these prior their...
Extracellular vesicles (EVs) and microbubbles are nanoparticles in drug-delivery systems that both considered important for clinical translation. Current research has found EVs have the potential to be utilized as agents therapeutic targets various diseases. In combination with EVs, capable of delivering chemotherapeutic drugs tumor sites neighboring damaged tissues. However, there no standards evaluate or compare benefits (natural carrier) versus (synthetic drug carriers. Both carriers...
Cell surfaces are covered with a dense carbohydrate layer referred to as the glycocalyx. Because different cell types express glycan signatures, it is of paramount importance have robust methods analyze glycome living cells. To achieve this, common procedure involves lysis and extraction membrane (glyco)proteins yields major proportion high-mannose N-glycans that most likely stem from intracellular proteins derived ER. Using HEK 293 cells model system, we developed reproducible, sensitive,...
Mesenchymal stem cells (MSCs) are multipotent that easy to isolate and expand, develop into several tissues, including fat, migrate diseased organs, have immunosuppressive properties secrete regenerative factors. This makes MSCs ideal for medicine. For application regulatory purposes, knowledge of (bio)markers characterizing their development stages is paramount importance. The cell surface coated with glycans possess lineage-specific nature, which be promising candidate markers. In the...
Acute kidney injury (AKI) is the abrupt loss of renal function, for which only supportive therapies exist. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have been shown to be therapeutically effective in treating AKI by spurring endogenous proliferation and survival while suppressing inflammation. Pre-treating kidneys with pulsed focused ultrasound (pFUS) has also enhance MSC therapy AKI, but its role MSC-derived EV remains unexplored. Using a mouse model...
Diseases of the kidney contribute a significant morbidity and mortality burden on society. Localized delivery therapeutics directly into kidney, via its arterial blood supply, has potential to enhance their therapeutic efficacy while limiting side effects associated with conventional systemic delivery. Targeted in humans is feasible given that we can access renal supply using minimally invasive endovascular techniques imaging guidance. However, there currently no described way reproduce or...
Acute kidney injury (AKI) is characterized by a sudden failure of renal function, but despite increasing worldwide prevalence, current treatments are largely supportive, with no curative therapies. Mesenchymal stromal cell (MSC) therapy has been shown to have promising regenerative effect in AKI limited the ability cells home damaged tissue. Pulsed focused ultrasound (pFUS), wherein target tissues sonicated short bursts sound waves, reported enhance MSC homing upregulating local signals....