A5016097291- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Endoplasmic Reticulum Stress and Disease
- Congenital Diaphragmatic Hernia Studies
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal disorders and treatments
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Autophagy in Disease and Therapy
- Neonatal Respiratory Health Research
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Advanced MRI Techniques and Applications
- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Neuroimaging Techniques and Applications
- Cancer Cells and Metastasis
Kansai Medical University
2020-2025
Kyushu University
2024-2025
Japanese Foundation For Cancer Research
2023-2025
Kyushu Hospital
2019
Otsu Red Cross Hospital
2011
Nara Medical University
2008
Kansai University
2004-2008
Fujita Health University
1999
Anaplastic lymphoma kinase (ALK)-tyrosine inhibitors rarely elicit complete responses in patients with advanced ALK-rearranged non-small cell lung cancer (NSCLC), as a small population of tumor cells survives due to adaptive resistance. Therefore, we focused on the mechanisms underlying resistance lorlatinib and therapeutic strategies required overcome them. We found that epidermal growth factor receptor (EGFR) signaling was involved NSCLC, activation which induced by heparin-binding...
ABSTRACT Anaplastic lymphoma kinase (ALK) rearranged non‐small cell lung cancer (NSCLC) shows marked tumor shrinkage by ALK‐tyrosine inhibitors (TKIs). However, tumors almost inevitably relapse owing to the development of acquired resistance. Resistance mechanisms include secondary ALK mutations and activation bypass pathways, such as cMET, cKIT, or EGFR, though some remain unknown. In this study, we analyzed alectinib‐resistant patient samples identified a significant increase in AXL...
Recent advancements in chemotherapy, including immune checkpoint inhibitors, sometimes achieve complete remission cases of stage IV lung cancer. On the other hand, immune-related adverse events may occur despite showing successful oncological effects. Herein, we report a rare case patient who underwent salvage resection after inhibitor therapy for IVB cancer, which led to confirmed not only pathological but also complications with aspergilloma as result powerful effect chemotherapy...
Approximately 15 % of patients with resected pathogenic stage IA lung adenocarcinoma develop recurrent disease, indicating the formation a cancer metastasis-promoting microenvironment. MECA-79 epitope is glycan core structure modulating immune response, normally expressed on high endothelial venules. Recently, ectopic expression has been discovered in several cells and was associated poor prognosis. In this retrospective cohort study, we aimed to investigate clinical pathological...
Abstract ALK-rearrangement is found in 3-5% of non-small cell lung cancer (NSCLC), and currently five ALK tyrosine kinase inhibitors (TKIs) have been approved, several TKIs are development. These contributed to a significant improvement patient prognosis, such that the median survival patients with advanced ALK-positive has exceeded 5 years. However, it problem cancers eventually relapse due drug resistance. To date, many investigators reported mechanism ALK-TKI resistance; secondary...
Abstract Background and Aim Although sessile serrated adenoma/polyps (SSA/Ps) are considered to be premalignant lesions rapidly progress carcinomas after they develop cytological dysplasia (CD), a treatment strategy for SSA/Ps in Asian countries is still being debated has not yet been established. The present study aimed propose SSA/Ps. Methods Histopathological data of patients, who underwent colonoscopy at our center between January 2011 December 2016, were reviewed. Data patients with ≥ 1...
Abstract Thoracic SMARCA4‐deficient undifferentiated tumors are a new type of neoplasm that commonly occur in the mediastinum, progress rapidly, and show poorer prognosis. We report case thoracic tumor right cavity patient with history heavy smoking presenting respiratory distress hemoptysis. Imaging showed pleural effusion thickening. A diagnostic biopsy yielded multiple white nodules pale bloody accumulated cavity. Histopathologically, cells were large, some exhibited rhabdoid cytology,...
We previously reported that nicotine protected against tunicamycin (Tm)-induced ER stress-mediated apoptosis, but not thapsigargin (Tg)-induced apoptosis in PC12 cells. In the present study, we report expression of glucose-regulated protein 78 (GRP78) was suppressed by Tm-treated Interestingly, GRP78 changed Tg-treated Moreover, reduced activation caspase-12 cells, These results suggest prevented Tm-induced attenuating an early stage stress. It possible suppression achieved through Ire1-XBP1...
The surgical Apgar score, calculated using 3 intraoperative variables (blood loss, lowest mean arterial pressure and heart rate), is associated with mortality in cancer surgery. original score has less applicability lung surgery; therefore, we innovated the modified pulmonary additional oxygen saturation representing parenchymal damage cardiopulmonary dynamics.We retrospectively analysed data of 691 patients who underwent surgery for primary between 2015 2019 at a single institute. We...
Although tyrosine kinase inhibitor (TKI) therapy shows marked clinical efficacy in patients with anaplastic lymphoma kinase-positive (ALK+) and ROS proto-oncogene 1-positive (ROS1+) non-small cell lung cancer (NSCLC), most of these eventually relapse acquired resistance. Therefore, genome-wide CRISPR/Cas9 knockout screening was performed using an ALK+ NSCLC line established from pleural effusion without ALK-TKI treatment. After 9 days therapy, sequencing analysis performed, which identified...
Abstract Background Anomalous systemic arterial supply to the basal segment of lung (ABLL) is a relatively rare congenital anomaly characterized by aberrant blood flow lung. We experienced presentation ABLL, in which giant artery with same dimensions as that descending aorta flowed from celiac left lower lobe. Case An otherwise healthy 42-year-old man was referred our department due an abnormal chest X-ray. Enhanced computed tomography revealed huge and winding mural thrombus originating...
This study aimed to characterize patients’ symptom severity trajectories and distresses from video-assisted thoracoscopic lung resection the first post-discharge clinic visit. Seventy-five patients undergoing for diagnosed or suspected pulmonary malignancy prospectively recorded daily on a 0–10 numeric scale using MD Anderson Symptom Inventory until The causes of postoperative were surveyed, analyzed joinpoint regression. A rebound was defined as statistically significant positive slope...
Postoperative cerebral infarction is a rare but serious complication after lung cancer surgery. We aimed to investigate the risk factors and evaluate efficiency of our devised surgical procedure prevent infarction.We retrospectively examined 1,189 patients who underwent single lobectomy for at institution. identified investigated preventive effects performing resection pulmonary vein as last step during left upper lobectomy.Among patients, we 5 male (0.4%) with postoperative infarction. All...
Abstract Thymic squamous cell carcinoma (TSQCC), accounting for 70–80% of thymic cases, is distinct from thymoma. However, differential diagnosis type B3 thymoma sometimes challenging, even with established markers TSQCC, including KIT and CD5, which are expressed in ~ 80% TSQCCs 3% thymomas. Novel TSQCC-specific would facilitate precise optimal treatment. Herein, we found that preferentially antigen melanoma (PRAME) may be a novel diagnostic marker. We comprehensively profiled 770...
Abstract OBJECTIVES This study aimed to elucidate the outcomes of emergency salvage surgery following life-threatening events (serious haemorrhage and/or infections) among patients with lung cancer who had undergone chemo- radiotherapy. Materials and Methods We analysed data patient from 2015 2020, retrospectively. The clinical characteristics, including preoperative treatment, perioperative survival time, were analysed. RESULTS Of 862 underwent primary surgeries, 10 (1.2%) surgeries....
Abstract Background IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition that predominantly involves exocrine organs. Concerning its thoracic presentation, it often manifests as interstitial lung or fibrosing mediastinitis. It very rare for IgG4-RD to form well-defined mass in the anterior mediastinum, mimicking an encapsulated thymoma. Case presentation An 82-year-old man with autoimmune pancreatitis under treatment oral corticosteroids was found have peripancreatic...