Yuki Shimizu
A5102912735- Dark Matter and Cosmic Phenomena
- Astrophysics and Cosmic Phenomena
- Nuclear physics research studies
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Neutrino Physics Research
- Nuclear Physics and Applications
- Radiation Therapy and Dosimetry
- Solar and Space Plasma Dynamics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- High-Energy Particle Collisions Research
- Radiation Detection and Scintillator Technologies
- Pulsars and Gravitational Waves Research
- Atomic and Molecular Physics
- Gamma-ray bursts and supernovae
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Nuclear reactor physics and engineering
- PI3K/AKT/mTOR signaling in cancer
- Advanced Data Storage Technologies
- Particle accelerators and beam dynamics
- Advanced NMR Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
Kanagawa University
2016-2024
RIKEN Nishina Center
2010-2024
The University of Tokyo
2010-2024
Louisiana State University
2018-2024
University of California, Los Angeles
2020-2023
Kyoto Prefectural University of Medicine
2023
Japanese Red Cross Society Kyoto Daini Hospital
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Pisa
2023
University of Siena
2023
Osaka University
2001-2023
We present a search for non-zero theta_{13} and deviations of sin^2 theta_{23} from 0.5 in the oscillations atmospheric neutrino data Super-Kamiokande -I, -II, -III. No distortions flux consistent with are found both mass hierarchy hypotheses agreement data. The best fit at Delta m^2 = 2.1 x 10^-3 eV^2, 0.0, =0.5. In normal (inverted) constrained one-dimensional 90% C.L. to < 0.04 (0.09) 1.9 (1.7) 2.6 (2.7) eV^2. mixing angle is within 0.407 <= 0.583
Extended results on the cosmic-ray electron $+$ positron spectrum from 11 GeV to 4.8 TeV are presented based observations with Calorimetric Electron Telescope (CALET) International Space Station utilizing data up November 2017. The analysis uses full detector acceptance at high energies, approximately doubling statistics compared previous result. CALET is an all-calorimetric instrument a total thickness of 30 ${X}_{0}$ normal incidence and fine imaging capability, designed achieve large...
In this paper, we present the analysis and results of a direct measurement cosmic-ray proton spectrum with CALET instrument onboard International Space Station, including detailed assessment systematic uncertainties. The observation period used in is from October 13, 2015 to August 31, 2018 (1054 days). We have achieved very wide energy range necessary carry out measurements 50 GeV 10 TeV covering, for first time space, single whole interval previously investigated most cases separate...
Abstract ROS1 gene rearrangement was observed in around 1–2 % of NSCLC patients and several other cancers such as cholangiocarcinoma, glioblastoma, or colorectal cancer. Crizotinib, an ALK/ROS1/MET inhibitor, is highly effective against -rearranged lung cancer used clinic. However, crizotinib resistance emerging issue, mechanisms, secondary kinase-domain mutations (e.g., ROS1-G2032R) have been identified crizotinib-refractory patients. Here we characterize a new selective ROS1/NTRK DS-6051b,...
Taletrectinib (DS-6051b/AB-106) is an oral, tyrosine kinase inhibitor of ROS1 and NTRK with potent preclinical activity against G2032R solvent-front mutation among others. We report the first-in-human U.S. phase I results taletrectinib.Patients ≥18 years old neuroendocrine tumors, tumor-induced pain, or tumors harboring ROS1/NTRK rearrangements were eligible. Accelerated titration followed by modified continuous reassessment method escalation overdose control was used (50-1,200 mg once daily...
A precise measurement of the cosmic-ray proton spectrum with Calorimetric Electron Telescope (CALET) is presented in energy interval from 50 GeV to 60 TeV, and observation a softening above 10 TeV reported. The analysis based on data collected during ∼6.2 years smooth operations aboard International Space Station covers broader range respect previous flux by CALET, an increase available statistics factor ∼2.2. Above few hundred we confirm our progressive spectral hardening higher...
We present the results of a direct measurement cosmic-ray helium spectrum with CALET instrument in operation on International Space Station since 2015. The observation period covered by this analysis spans from October 13, 2015, to April 30, 2022 (2392 days). very wide dynamic range allowed for collection data over large energy interval, ∼40 GeV ∼250 TeV, first time single low Earth orbit. measured shows evidence deviation flux power law more than 8σ progressive spectral hardening few...
Excitation energy spectra of 89ΛY, 51ΛV, and 12ΛC have been measured via the (π+,K+) reaction by using SKS spectrometer at K6 beam line in KEK 12-GeV Proton Synchrotron. In 89ΛY spectrum, obtained with an resolution 1.65 MeV (FWHM) highest statistics so far, we succeeded clearly observing a characteristic fine structure heavy Λ hypernuclear systems precisely obtaining series single-particle energies very wide excitation range more than 20 MeV, for first time. Also 51ΛV similar to that was...
The double-differential cross sections for the Ca48(p,n) and Ti48(n,p) reactions were measured at 300 MeV. A multipole decomposition technique was applied to spectra extract Gamow-Teller (GT) components. integrated GT strengths up an excitation energy of 30 MeV in Sc48 are 15.3±2.2 2.8±0.3 (p,n) (n,p) spectra, respectively. In additional found above 8 where shell models within fp shell-model space predict almost no strengths, suggesting that present description nuclear matrix element...
Recent rodent studies have shown that nanoparticles are distributed to breast milk, and more-detailed safety information regarding nanoparticle consumption by lactating mothers is required. Here, we used mice investigate the of use during lactation. When Ag Au were intravenously administered mice, milk without producing apparent damage mammary gland, amount increased with decreasing particle size. Orally also subsequently brains breast-fed pups. Ten-nanometer retained longer in pups' than...
In this paper, we present the measurement of energy spectra carbon and oxygen in cosmic rays based on observations with Calorimetric Electron Telescope International Space Station from October 2015 to 2019. Analysis, including detailed assessment systematic uncertainties, results are reported. The measured kinetic per nucleon $10\text{ }\text{ }\mathrm{GeV}/n$ $2.2\text{ }\mathrm{TeV}/n$ an all-calorimetric instrument a total thickness corresponding 1.3 nuclear interaction length. observed...
Here we report a design and synthesis of chemically functional polymer membrane by an interfacial polycondensation reaction multilayer flow inside microchannel. Single parallel dual-membrane structures are successfully prepared using organic/aqueous two-layer organic/aqueous/organic three-layer the microchannel followed reaction. By inner-channel membrane, permeation ammonia species through is achieved. Furthermore, horseradish peroxidase immobilized on one side surface to integrate chemical...
We have observed a clear peak below the ${\ensuremath{\Sigma}}^{+}$-production threshold in ${}^{4}\mathrm{He}({K}^{\ensuremath{-}},{\ensuremath{\pi}}^{\ensuremath{-}})$ reaction at $600\mathrm{MeV}/c$ and ${\ensuremath{\theta}}_{K\ensuremath{\pi}}{\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}4}^{\ensuremath{\circ}}$. This is confirmation of existence bound state ${}_{\ensuremath{\Sigma}}^{4}\mathrm{He}$, which was reported...
We have studied the (pi(-),K+) reaction on a silicon target to investigate sigma-nucleus potential. The inclusive spectrum was measured at beam momentum of 1.2 GeV/c with an energy resolution 3.3 MeV (FWHM) by employing superconducting kaon spectrometer system. compared theoretical calculations within framework distorted-wave impulse approximation, which demonstrates that strongly repulsive potential nonzero size imaginary part reproduces observed spectrum.
An experiment demonstrating the production of double-Lambda hypernuclei in (K(-),K(+)) reactions on (9)Be was carried out at D6 line BNL alternating-gradient synchrotron. The technique observation pions produced sequential mesonic weak decay, each pion associated with one unit strangeness change. results indicate a significant number double hypernucleus (4)(double Lambda)H and twin (4)(Lambda)H (3)(Lambda)H. relevant decay chains are discussed simple model mechanism is presented. implication...
In order to study the Sigma-nucleus optical potential, we measured inclusive (pi^-,K^+) spectra on medium-to-heavy nuclear targets: CH_2, Si, Ni, and Bi. The CH_2 target was used calibrate excitation energy scale by using elementary process p + pi^- -> K^+ Sigma^-, where C spectrum also extracted. calibration done with +-0.1 MeV precision. angular distribution of cross section measured, agreed well previous bubble chamber data, but better statistics, magnitudes sections were calibrated. All...
The Calorimetric Electron Telescope (CALET), in operation on the International Space Station since 2015, collected a large sample of cosmic-ray iron over wide energy interval. In this Letter measurement spectrum is presented range kinetic per nucleon from $10\text{ }\text{ }\mathrm{GeV}/n$ to $2.0\text{ }\mathrm{TeV}/n$ allowing inclusion list elements studied with unprecedented precision by space-borne instruments. based observations carried out January 2016 May 2020. CALET instrument can...
We present the measurement of energy dependence boron flux in cosmic rays and its ratio to carbon an interval from 8.4 GeV/n 3.8 TeV/n based on data collected by Calorimetric Electron Telescope (CALET) during ∼6.4 yr operation International Space Station. An update spectrum is also presented with increase statistics over our previous measurement. The observed shows a spectral hardening at same transition E_{0}∼200 C spectrum, though B fluxes have different dependences. index found be...
Differential cross sections of isoscalar and isovector spin-M1 (0(+)→1(+)) transitions are measured using high-energy-resolution proton inelastic scattering at E(p)=295 MeV on (24)Mg, (28)Si, (32)S, (36)Ar 0°-14°. The squared nuclear transition matrix elements deduced from the differential by applying empirically determined unit based assumption isospin symmetry. ratios accumulated up to E(x)=16 compared a shell-model prediction 1.01(9) for 0.61(6) transitions, respectively. Thus, no...
The key parameter to discuss the possibility of pion condensation in nuclear matter, i.e., so-called Landau-Migdal g^{'}, was extracted by measuring double-differential cross sections for (p,n) reaction at 216 MeV/u on a neutron-rich doubly magic unstable nucleus, ^{132}Sn with quality comparable data taken stable nuclei. strengths Gamow-Teller (GT) transitions from leading ^{132}Sb exhibit GT giant resonance (GTR) excitation energy 16.3±0.4(stat)±0.4(syst) MeV width Γ=4.7±0.8 MeV....
Very recently, the LHCb collaboration has reported new result about hidden-charm pentaquarks: $P_c(4312)$ near $\bar{D}Σ_c$ threshold, and $P_c(4440)$ $P_c(4457)$ $\bar{D}^*Σ_c$ threshold. We study heavy quark spin (HQS) multiplet structures of these newly $P_c$ pentaquarks under symmetry based on hadronic molecular picture. point out that is $J^P = 1/2^-$ member an HQS triplet, are 3/2^-$ triplet singlet with 3/2^-$. Namely, one belong to triplet. The structure predicts existence 5/2^-$...
γ emission probabilities from unbound states in 78,80Se, populated by a neutron-transfer reaction (d,p) on 77,79Se nuclei inverse kinematics, were measured directly detecting residues. Assuming the spin distribution at respective excitation energy of state, cross-sections 79Se(n,γ)80Se evaluated using probabilities. The surrogate-ratio method with experimental 78,80Se was also employed to deduce 79Se(n,γ) incorporating theoretical evaluations neutron-capture isomeric state 77Se. Our two are...