A5005046774- Bladder and Urothelial Cancer Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Reproductive tract infections research
- Food Allergy and Anaphylaxis Research
- Prostate Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- Neurosurgical Procedures and Complications
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA Research and Splicing
- Traumatic Brain Injury and Neurovascular Disturbances
Université Laval
2021-2023
Centre Hospitalier de l’Université de Montréal
2019
Aneurysmal subarachnoid hemorrhage (SAH) is a catastrophic disease with devastating consequences, including high mortality rate and severe disabilities among survivors. Inflammation induced following SAH, but the exact role phenotype of innate immune cells remain poorly characterized. We investigated inflammatory components early brain injury in an animal model SAH patients.SAH was through injection blood space C57Bl/6 J wild-type mice. Prospective collections were obtained at 12 h, days 1,...
Men are three to four times more likely be diagnosed with bladder cancer (BCa) than women, who often have aggressive tumors. Intravesical bacillus Calmette-Guerin (BCG) for non-muscle-invasive (NMIBC) is one of the first immunotherapies, use immune checkpoint inhibitors BCa immunotherapy expanding. Sex hormones, and notably androgens, might impact outcome these therapies.To understand immunological sex differences in investigate androgen receptor (AR) inhibition as a novel strategy improve...
Within the prostate tumor microenvironment (TME) there are complex multi-faceted and dynamic communication occurring between cancer cells immune cells. Macrophages key which infiltrate surround recognized to significantly contribute resistance metastases. Our understanding of their function in TME is commonly based on vitro vivo models, with limited research confirm these model observations human prostates. Macrophage infiltration was evaluated within prostates after 72 h culture fresh...
Emerging evidence associates translation factors and regulators to tumorigenesis. However, our understanding of translational changes in cancer resistance is still limited. Here, we generated an enzalutamide-resistant prostate (PCa) model, which recapitulated key features clinical PCa. Using this model poly(ribo)some profiling, investigated global that occur during acquisition PCa resistance. We found cells exhibit overall decrease mRNA with a specific deregulation the abundance proteins...
You have accessJournal of UrologyCME1 May 2022MP06-13 TARGETING THE ANDROGEN RECEPTOR AXIS TO IMPROVE RESPONSE BLADDER CANCER IMMUNOTHERAPY Typhaine Gris, Marjorie Besançon, France-Hélène Joncas, Valérie Picard, Alain Bergeron, Yves Fradet, and Paul Toren GrisTyphaine Gris More articles by this author , BesançonMarjorie Besançon JoncasFrance-Hélène Joncas PicardValérie Picard BergeronAlain Bergeron FradetYves Fradet TorenPaul View All Author...