A5067188711- Metabolomics and Mass Spectrometry Studies
- Cannabis and Cannabinoid Research
- GABA and Rice Research
- High Altitude and Hypoxia
- Oxidative Organic Chemistry Reactions
- Cancer, Hypoxia, and Metabolism
- Lipid Membrane Structure and Behavior
- Synthesis and Biological Evaluation
- Coffee research and impacts
- Synthesis and Catalytic Reactions
- Adipokines, Inflammation, and Metabolic Diseases
- Psychedelics and Drug Studies
- Advanced Proteomics Techniques and Applications
- Chemical Synthesis and Analysis
- Carbon dioxide utilization in catalysis
- Infective Endocarditis Diagnosis and Management
- Cancer, Lipids, and Metabolism
- Food Chemistry and Fat Analysis
- Sphingolipid Metabolism and Signaling
- Polymer composites and self-healing
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Nutritional Studies and Diet
- Nitric Oxide and Endothelin Effects
- Erythrocyte Function and Pathophysiology
- Cardiovascular and Diving-Related Complications
University of Milan
2021-2025
Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how severity of disease affects level and composition lipids whether analysis may identify specific impairment linked to patients' outcome. Sera from 49 COVID-19 patients were analyzed untargeted lipidomics. Patients clustered according to: inflammation (C-reactive protein), hypoxia (Horowitz Index), coagulation state (D-dimer), kidney function (creatinine) age. exhibited remarkable distinctive...
α-Chlorophenylacetic acids are synthons with great potential but limited by the lack of a simple and generalizable method for their preparation from readily available precursors.
The metabolism of nitric oxide plays an increasingly interesting role in the physiological response human body to extreme environmental conditions, such as underwater, extremely cold climate, and at low oxygen concentrations. Field studies need development analytical methods measure nitrite nitrate plasma red blood cells with high requirements accuracy, precision, sensitivity. An optimized spectrophotometric Griess method for nitrite–nitrate affords sensitivity millimolar range precision...
The main concerns in targeted "sphingolipidomics" are the extraction and proper handling of biological samples to avoid interferences achieve a quantitative yield well representing all sphingolipids matrix. Our work aimed compare different pre-analytical procedures evaluate derivatization step for sphingoid bases quantification, improve sensitivity. We tested four protocols from human plasma, at temperatures durations, two conversion into phenylthiourea derivatives. Different columns...
The recently reported efficient conversion of cyclic ketones to lactones by Oxone in neutral buffered water is extended heterocyclic ketones, namely, N-Boc azaketones and oxoethers with the aim obtaining N-protected azalactones their analogues oxygen place nitrogen. N-Boc-4-piperidinone all were successfully oxidized lactones, while azacyclic nitrogen α-positioned carbonyl univocally transformed into N-Boc-ω-amino acids N-Boc-N-formyl-ω-amino operating alkaline DMF, respectively.
Although the human body may dynamically adapt to mild and brief oxygen shortages, there is a growing interest in understanding how metabolic pathways are modified during sustained exposure chronic hypoxia. Located at an equivalent altitude of approximately 3,800 m asl, Concordia Station Antarctica represents opportunity study course adaption hypoxia with reduced impact potentially disturbing variables else than deprivation. We recruited seven healthy subjects who spent 10 months Station,...
Cannabis as a therapeutic agent is increasing in popularity all around the globe, particularly Western countries, and its potential now well assessed. On other hand, each country has own regulation for preparation of cannabis macerated oils; Italy, there are only few methods allowed. With this work, we aim to perform stability study oils produced with novel method extraction cannabinoids from inflorescence. Three different varieties were used, without adding tocopherol acetate an...
3-Ethoxycarbonyl-1,4-benzodioxin-2-carboxylic acid, a novel 2,3-disubstituted benzodioxin, was prepared from readily available 1,4-benzodioxin-2-carboxylic acid by lithiation at C(3) and reaction with the electrophile ethyl chloroformate. The analytical characterization of product performed via IR, 1H-NMR, 13C-NMR, HRMS, HPLC-UV. Due to unsymmetrically disubstituted unsaturation, obtained monoester 1,4-benzodioxin-2,3-dicarboxylic is building block great potential in synthesis variety...
The management of food and food-related wastes represents a growing global issue, as they are hard to recycle dispose of. Foremost, waste can serve an important source biomasses. Particularly, fat-enriched biomasses receiving more attention for their role in the manufacturing biofuels. Nonetheless, many have been set aside over years. Wool wax, also known lanolin, has huge potential becoming typical atypical fatty acids. main aim this work was evaluate assess protocol fractioning acids from...
2-Substituted 1,4-benzodioxanes bearing one or more substituents at benzene are important templates in the design and synthesis of a large variety biologically active compounds. One most straightforward synthetic strategies to prepare them racemic form with 2-substituent susceptible further synthetically useful conversions is condensation commercially available methyl 2,3-dibromopropionate already suitably functionalized catechol. Here, we obtain 8- 5-nitro-1,4-benzodioxane-2-carboxylate by...
The CA.ME.LI.A (CArdiovascular risks, MEtabolic syndrome, LIver and Autoimmune disease) epidemiological study was conducted in Abbiategrasso (Milan, Italy) to identify risk factors for metabolic cardiovascular disease an apparently healthy population of northern Italy. (
Over several decades, many different strategies have been reported to prepare 4-, 5-, 6-, and 7hydroxybenzofuran (HBF), which are very important synthetic intermediates.Interested in addition of their 2lithiated O-protected derivatives transient 1-pyrroline as a straightforward way nicotinoids, we developed unique two-step procedure obtain 7-HBF from 2,6-, 2,5-, 2-4-and 2,3dihydroxyacetophenone, respectively, by conversion into 6-and 7-hydroxybenzofuranone successive reduction these latter...
The therapeutic use of Cannabis oil extracts is constantly increasing. However, in Italy, they are allowed to be prepared with only a few methods and matrices. With this work, we aimed assess how the different processes might affect chemical composition two matrices (olive oils medium chain triglycerides - MCT), accounting as variables for both presence dried apices female flower adding tocopherol acetate an antioxidant. macerated were four according Italian legislation (Romano-Hazekamp,...