A5060440099- Analog and Mixed-Signal Circuit Design
- CCD and CMOS Imaging Sensors
- Optical Network Technologies
- Advancements in Semiconductor Devices and Circuit Design
- Low-power high-performance VLSI design
- Infrared Target Detection Methodologies
- Semiconductor Lasers and Optical Devices
- Photonic and Optical Devices
- Advancements in PLL and VCO Technologies
- Advanced Photonic Communication Systems
- X-ray Diffraction in Crystallography
- Radio Frequency Integrated Circuit Design
- Crystallization and Solubility Studies
- Advanced Optical Network Technologies
- Analytical Chemistry and Sensors
- Nanoplatforms for cancer theranostics
- Thin-Film Transistor Technologies
- Immunotherapy and Immune Responses
- Advanced Fiber Optic Sensors
- Advanced Optical Sensing Technologies
- Photovoltaic System Optimization Techniques
- Neuroscience and Neural Engineering
- Gyrotron and Vacuum Electronics Research
- Remote Sensing and LiDAR Applications
- Embedded Systems Design Techniques
Nanjing Agricultural University
2025
Shenzhen Bay Laboratory
2023-2025
458th Hospital PLA
2024
Zhejiang University
2024
Chongqing University
2024
Shandong University
2012-2024
Peng Cheng Laboratory
2023-2024
University of Memphis
2020-2023
Antea Group (France)
2023
Institute of Electrical and Electronics Engineers
2020-2023
Abstract Backgrounds Immune checkpoint blockade (ICB) is widely considered to exert long-term treatment benefits by activating antitumor immunity. However, many cancer patients show poor clinical responses ICB due in part the lack of an immunogenic niche. Focal adhesion kinase (FAK) frequently amplified and acts as immune modulator across types. evidence illustrates that targeting FAK most effective combination therapy rather than monotherapy. Methods Here, we used drug screening, vitro vivo...
Abstract Objective:
To develop and validate a novel multidimensional readout method that significantly reduces the number of channels in PET detectors while maintaining high spatial energy performance.

Approach:
We arranged 3×3×4 SiPM array multiple dimensions employed row/column/layer summation with resistor-based splitting circuit. We then applied denoising methods to enhance peak-to-valley ratio decoding map, ensuring accurate crystal-position...
It is proposed and demonstrated experimentally for the first time to achieve desired phase shifts within one channel of a sampled Bragg grating by changing sampling period. Only ordinary masks submicrometer precision are needed, leading improved flexibility, repeatability, cost-effectiveness in fiber design fabrication especially when multiple mutable required. Based on this method, /spl pi/-shift two bipolar encoders direct-sequence optical code-division multiple-access systems obtained...
Enteric and diarrheal diseases pose a significant threat to infant health, highlighting the im-portance of immune defenses in early life, especially maternal protection, establishing robust gastrointestinal environment. Surfactin, bioactive peptide from Bacillus subtilis, has immuno-modulatory properties, yet its influence on offspring via gut interference is not fully un-derstood. The study examines effects surfactin consumption breast milk's im-munological properties consequent...
The extraction of molecular annotations from scientific literature is critical for advancing data-driven research. However, traditional methods, which primarily rely on human curation, are labor-intensive and error-prone. Here, we present an LLM-based agentic workflow that enables automatic efficient data with high accuracy. As a demonstration, our successfully delivers dataset containing over 91,000 enzyme kinetics entries around 3,500 papers. It achieves average F1 score above 0.9...
Background: Enteric and diarrheal diseases pose a significant threat to infant health, highlighting the importance of immune defenses in early life, especially maternal protection, establishing robust gastrointestinal environment. Surfactin, bioactive peptide from Bacillus subtilis, has immunomodulatory properties, yet its influence on offspring via gut interference is not fully understood. This study examines effects surfactin consumption breast milk’s immunological properties consequent...
A novel method to generate ultra-wideband (UWB) monocycle pulses based on birefringence time delay in polarisation-maintaining fibre (PMF) is proposed and experimentally demonstrated. Two polarity-reverse are generated by polarisation modulation using a single phase modulator. They delayed PMF with enough pulse.
Three isostructural cyano-bridged 3d-4f compounds, [YFe(CN)6(hep)2(H2O)4] (1), [DyFe(CN)6(hep)2(H2O)4] (2), and [DyCo(CN)6(hep)2(H2O)4] (3), were successfully assembled by site-targeted substitution of the 3d or rare-earth ions. All compounds have been structurally characterized to display slightly distorted pentagonal-bipyramidal local coordination geometry around Magnetic analyses revealed negligible magnetic coupling in compound 1, antiferromagnetic intradimer interaction 2, weak...
A distributed feedback fiber laser employing an equivalent phase shift (EPS) of /spl pi/ is studied theoretically and experimentally for the first time. The EPS formed through extending one sampling period by 50% in center a sampled Bragg grating. An output power 0.20 mW with sidemode suppression 67 dB observed.
This paper presents an all-digital self-calibrated delay-line based temperature sensor. A continuous self-calibration technique is proposed to remove process variations and generate direct digital representations of temperature. power saving scheme using a hybrid counter/pulse position decoder also introduced without any increase in area overhead. Four different architectures including traditional long short delay-lines, the sensor with delay-lines are implemented on multiple 65nm Cyclone...
This brief proposes a successive approximation register (SAR) analog-to-digital converter (ADC) whose readout speed is improved by 33%, through applying digital error correction (DEC) method, compared to an alternative without using the DEC technique. The proposed addition-only alleviates ADC's incomplete settling errors, hence improving conversion rate while maintaining accuracy. It based on binary bridged SAR architecture with 4 redundant capacitors and cycles, which ensure linearity of 10...
A novel and simple method of optical generation millimetre-wave signals employing four-wave mixing (FWM) effect in a semiconductor amplifier (SOA) is proposed. This approach capable generating double, quadruple six times the microwave source frequency with extremely high spectral purity stability. 41.7 GHz (6×fundamental) 3 dB linewidth less than 20 Hz phase noise −75 dBc/Hz at 1.6 kHz offset obtained.
5567 Background: IN10018 is a highly potent and selective oral inhibitor of focal adhesion kinase (FAK). synergistic with PLD against ovarian cancer in PDX models. This study evaluated the safety, tolerability, antitumor activities combination patients platinum-resistant (PROC). Methods: an open-label phase Ib trial PROC (high-grade serous carcinoma only). Patient were treated PLD. has dose-confirmation part dose-expansion part. Dose-expansion was conducted at RP2D dose level to evaluate...
This paper presents a thermal sensing and VLSI management scheme using an array of on-chip all-digital delay-line based temperature sensors. A fully digital self-calibration method that removes the sensors' sensitivities to supply voltage process variations is proposed. The proposed calibration assigns unique correction factor, N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</sub> each sensor, making all calibrated outputs be same at...
This brief proposes employing each of the classical 4 transistor (4T) pinned photodiode (PPD) CMOS image sensor (CIS) pixels, for both imaging and temperature measurement, intended compensating CISs' dark current, signal non-uniformity (DSNU). The proposed sensors rely on thermal behavior MOSFETs working in subthreshold region, when biased with ratiometric currents sequentially. Without incurring any additional hardware or penalty to CIS, they are measured have curvature errors less than...
This paper proposes various types of on-chip smart temperature sensors, intended for thermal compensation dark current in CMOS image sensors (CIS). It four different architectures metal-oxide-semiconductor (MOS)-based and bipolar junction transistor (BJT)-based inside outside the CIS array. Both MOS-based make use dependence MOS transistors working subthreshold region with ratiometric currents are quantized by 14-bit first-order incremental delta-sigma analog-to-digital converters (ADCs)....
This paper presents a 4-bit windowed delay line ADC implemented in 65 nm CMOS technology for VLSI dynamic voltage scaling power management applications. Good linearity is achieved the proposed and area efficient without use of resistors compensation. The circuit performance was analyzed theoretically verified experimentally. measured DNL within ±0.25 LSB INL ±0.15 LSB. It occupies an 0.009 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
For wireless sensor networks (WSNs), it is constantly demanded to process information more rapidly with less energy and area cost. Currently, processor based solutions have difficult achieve high processing speed low-power consumption. A novel partial dynamic reconfiguration-based WSN node proposed in this study. First, a architecture described, which contains reconfigurable hardware (HW). The can be dynamically remotely reconfigured. Then the associated design work flow are presented. As...
This paper presents an area and power efficient delay line based temperature sensor for on-chip monitoring. can be deployed in large numbers on a microprocessor chip to facilitate advanced thermal management techniques. The proposed self-calibration design eliminates the effort associated with two-point calibration commonly found conventional sensors. In addition, it saves digital decoding by use of both tab counter decoding. Measurement results 65nm CMOS show that consumes 0.02 nJ energy...
This paper analyzes and compensates for process temperature dependency among a (Complementary Metal Oxide Semiconductor) CMOS image sensor (CIS) array. Both the analysis compensation are supported with experimental results on CIS’s dark current, signal non-uniformity (DSNU), conversion gain (CG). To model to compensate variations, sensors based pixel source follower (SF)’s transconductance gm,SF have been proposed be compared against measurement of SF ASF. In addition, ASF’s thermal has...
Broadband Radio frequency (RF) photonic front-ends are one of the vital applications microwave photonics. A tunable and broadband RF front-end integrating with optoelectronic oscillator (OEO) based local has been proposed experimentally demonstrated, in which only phase modulator (PM) is employed thanks to characteristic PM. The silicon-on-insulator narrow-bandwidth band-pass filter introduced for signal processing. application condition discussed performance also measured. SFDR at a about...
This paper presents an analysis and calibration of process variations for array temperature sensors, which are incorporated into a CMOS image sensor chip. Making use the experimental results more than 500 sensors implemented on same chip, proposed method has removed their from 14.3 % to 2.5 (3 sigma).