A5017775471- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Particle Detector Development and Performance
- Nuclear Physics and Applications
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Advanced Optical Sensing Technologies
- Advanced X-ray and CT Imaging
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advancements in PLL and VCO Technologies
- Analog and Mixed-Signal Circuit Design
- Ultrasound Imaging and Elastography
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Radiation Effects in Electronics
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Tendon Structure and Treatment
- Radiopharmaceutical Chemistry and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Digital Radiography and Breast Imaging
- Photoacoustic and Ultrasonic Imaging
- Prostate Cancer Diagnosis and Treatment
Shenzhen Bay Laboratory
2020-2025
Tianjin University
2024
Capital Medical University
2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2023
University of Chinese Academy of Sciences
2023
Guangzhou Medical University
2023
Sun Yat-sen University
2023
Peking University Shenzhen Hospital
2023
Chongqing University
2020-2022
Lawrence Berkeley National Laboratory
2010-2020
Ethanol sensing has important applications, including breath alcohol checkers. A highly selective and stable ethanol sensor—see Figure—based on single-crystalline divanadium pentoxide nanobelts is described, representing a new strategy for the design of novel practicable gas sensors. Potential problems caused by changes relative humidity or presence other gases are ruled out.
Abstract Introduction The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge Alzheimer’s disease (AD). However, the characteristics prevalence AD in this area are still unclear due to rarely available community-based neuroimaging cohort. Methods Following standard protocols Disease Neuroimaging Initiative, Healthy Aging Brain Study (GHABS) was initiated 2021. GHABS participants completed clinical assessments, plasma...
Radioactive prostate-specific membrane antigen (PSMA)-targeting agents are clinically useful for the diagnosis and treatment of patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). Neuroendocrine-differentiated (NEPC), a highly aggressive subtype that is strongly associated poor clinical prognosis, may present reduced PSMA expression evade detection PSMA-targeted agents. Several studies have shown elevated uptake somatostatin receptor 2 (SSTR2) ligands in...
Increasing the image quality of positron emission tomography (PET) is an essential topic in PET community. For instance, thin-pixelated crystals have been used to provide high spatial resolution images but at cost sensitivity and manufacture expense. In this paper, we proposed approach enhance noise property for scanners with large pixelated crystals. To address problem coarse blurred sinograms parallax errors associated crystals, developed a data-driven, single-image superresolution (SISR)...
We describe the design and operation of a high-throughput facility for synthesizing thousands inorganic crystalline samples per year evaluating them as potential scintillation detector materials. This includes robotic dispenser, arrays automated furnaces, dual-beam X-ray generator diffractometry luminescence spectroscopy, pulsed time response measurements, computer-controlled sample changers, an optical spectrometer, network-accessible database management system that captures all synthesis...
We present the design for OpenPET, an electronics readout system designed prototype radiotracer imaging instruments. The critical requirements are that it has sufficient performance, channel count, density, and power consumption to service a complete camera, yet be simple, flexible, customizable enough used with almost any detector or camera design. An important feature of this is each analog input processed independently. Each can configured accept signals either polarity as well...
We present a nonuniform multiphase (NUMP) method to construct high-resolution time-to-digital converter (TDC) for low-cost field-programmable gate array (FPGA) devices. The NUMP involves system clock being passed through series of delay elements generate multiple clocks with different phase shifts. phases the rising and falling edges all are sorted in order states latched when hit signal arrives. sizes time bins (and precision) not limited by uniformity minimum value delays lines. In theory,...
We describe a long axial field-of-view (FOV) PET scanner for high-sensitivity and total-body imaging of nonhuman primates present the physical performance first phantom animal results. <b>Methods:</b> The mini-EXPLORER was built using components clinical reconfigured with detector ring diameter 43.5 cm an length 45.7 cm. National Electrical Manufacturers Association (NEMA) NU-2 NU-4 phantoms were used to measure sensitivity count rate performance. Reconstructed spatial resolution...
Abstract Objective:&#xD;To develop and validate a novel multidimensional readout method that significantly reduces the number of channels in PET detectors while maintaining high spatial energy performance.&#xD;&#xD;Approach:&#xD;We arranged 3×3×4 SiPM array multiple dimensions employed row/column/layer summation with resistor-based splitting circuit. We then applied denoising methods to enhance peak-to-valley ratio decoding map, ensuring accurate crystal-position...
Abstract Background Gamma‐ray detection plays a crucial role in the fields of biomedicine, space exploration, national defense, and security. High‐precision gamma photon relies on scintillation crystals, which attenuate rays through mechanisms such as photoelectric effect Compton scattering. These interactions generate light signals within crystal, are subsequently converted into electronic using photodetectors, enabling accurate readout, analysis. Purpose Improving readout efficiency...
The performance of radiation detectors used in positron-emission tomography (PET) is determined by the intrinsic properties scintillators, geometry and surface treatment scintillator crystals electrical optical characteristics photosensors. Experimental studies were performed to assess timing resolution energy constructed with samples different materials (LaBr3, CeBr3, LFS, LSO, LYSO: Ce, Ca GAGG) that fabricated into shapes various treatments. saturation correction SiPMs was applied for...
Positron emission tomography (PET) is widely used in the diagnosis of tumors, cardiovascular system diseases, and neurological diseases. Scintillation crystals are an important part PET scanners; they can convert γ photons into fluorescent to obtain their energy, time, position information. Currently, research goal find scintillation with better performance. In this work, principle introduced, properties requirements different scanners analyzed. At present, Lu2(1−x)Y2xSiO5 (LYSO) crystal...
The conventional front-end electronics for PET imaging consist of an energy circuit and a timing circuit. A single channel in typically requires several amplifiers, ADC TDC. In this paper, we present novel electronic design using 1-bit sigma-delta (Σ-Δ) modulation FPGA. new only one analog amplifier per channel. output the is read directly by Both calculation are implemented FPGA firmware. scope paper to introduce detail evaluate its performance dark current measurements. Simulink...
Reading out from large-scale silicon photomultiplier (SiPM) arrays is a fundamental technical obstacle blocking the application of revolutionary SiPM technologies in nuclear imaging systems. Typically, it requires using dedicated application-specific integrated circuits (ASICs) that need long iterative process, special expertise, and tools to develop. The pico-positron emission tomography (Pico-PET) electronics system an advanced 100-channel readout based on 1-bit sigma-delta modulation...
We present the design for OpenPET, an electronics readout system designed prototype radiotracer imaging instruments. The critical requirements are that it has sufficient performance, channel count, density, and power consumption to service a complete camera, yet be simple, flexible, customizable enough used with almost any detector or camera design. An important feature of this is each analog input processed independently. Each can configured accept signals either polarity as well...
A human-to-computer system that includes a wireless intra-oral module, coordinator and distributed controllers, is presented. The state-of-the-art ZigBee protocol employed to achieve reliable, low- power cost-efficient communication between the tongue, computer controllers. By manipulating five buttons on module using subject can control cursors, menus, wheelchair, lights, TV, phone robotic devices. designed improve life quality of patients with stroke spinal cord injury.
Abstract Extracellular β-amyloid plaques and intracellular neurofibrillary tau tangles are the primary hallmarks of Alzheimer's disease. β-Amyloid pathology can be directly quantified by positron emission tomography imaging or indirectly measuring decrease cerebrospinal fluid β-amyloid42/β-amyloid40 ratio. Although these two biomarkers may considered interchangeable, they sometimes show discordance, particularly in early stage Individuals with positive only at amyloidosis compared to those...
Multi-modality imaging has an increasing role in the diagnosis and treatment of a large number diseases, particularly if both functional anatomical information are acquired accurately co-registered. Hence, there is resulting need for multi-modality phantoms order to validate image co-registration calibrate systems. We present our PET-ultrasound phantom development, including PET ultrasound images simple prostate phantom. use agar gelatin mixed with radioactive solution. also development...
Depth of interaction (DOI) decoding capability is great importance for positron emission tomography (PET) requiring high resolution. In this study, we presented a novel low-cost DOI detector design with four crystals coupling to one SiPM, based on the method rectangular light-sharing window (RLSW). A prototype was constructed, calibrated, and assessed using methods homogeneous radiation flood map analysis.The constructed 4 × array lutetium-yttrium oxyorthosilicate (LYSO) (2.95 mm 2.95 20 mm3...
This paper presents a unique preclinical positron emission tomography (PET) detector constructed with monolithic scintillator ring (MSR) and two rings of silicon photomultipliers (SiPM). The inner diameter, outer diameter length the MSR were 48.5 mm, 58.5 25.1 respectively. SiPM rings, 46 SiPMs, air-coupled to ends detector. center gravity (COG) artificial neural network (ANN) methods adapted decode positions gamma interactions in circumferential (θ) axial (Z) directions, Collimating...
This paper presented a non-uniform multiphase (NUMP) time-to-digital converter (TDC) implemented in field-programmable gate array (FPGA) with real-time automatic temperature compensation. NUMP-TDC is novel, low-cost, high-performance TDC that has achieved an excellent performance Altera Cyclone V FPGA. The root mean square (RMS) for the intrinsic timing resolution was 2.3 ps. However, propagation delays delay chain of some FPGAs (for example, 10 LP) vary significantly as changes. Thus,...