A5039042348- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Opioid Use Disorder Treatment
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Connexins and lens biology
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- Drug-Induced Adverse Reactions
- Traumatic Brain Injury Research
- Pharmaceutical Practices and Patient Outcomes
- Disaster Response and Management
- Emergency and Acute Care Studies
- Urticaria and Related Conditions
- Cardiac Arrhythmias and Treatments
- Acute Kidney Injury Research
- Poisoning and overdose treatments
- Electronic Health Records Systems
- Uterine Myomas and Treatments
- Potassium and Related Disorders
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Pediatric Pain Management Techniques
- Neonatal Health and Biochemistry
MetroHealth Medical Center
2013-2025
Case Western Reserve University
2013-2025
MetroHealth
2009-2025
University School
2023-2024
University Hospitals of Cleveland
2004
Rainbow Babies & Children's Hospital
2004
Hyperkalemia is a common life-threatening condition causing severe electrophysiologic derangements and arrhythmias. The beneficial effects of calcium (Ca 2+ ) treatment for hyperkalemia have been attributed to "membrane stabilization," by restoration resting membrane potential (RMP). However, the underlying mechanisms remain poorly understood. Our objective was investigate adverse therapeutic Ca treatment.
Traumatic brain injury (TBI) is a multifaceted condition associated with occupational, social, physical, cognitive, academic, and economic burdens. Mild TBI including traumatic intracranial hemorrhage (tICH), commonly discharged from the emergency department (ED). Despite complexity of factors contributing to outcomes, patient education comprehensive follow-up plans are frequently lacking. We examined health trajectories, recidivism, patterns patients ED tICH identify opportunities improve...
Background— Hypothermia is proarrhythmic, and, as the use of therapeutic hypothermia (TH) increases, it critically important to understand electrophysiological effects on cardiac myocytes and arrhythmia substrates. We tested hypothesis that hypothermia-enhanced transmural dispersion repolarization (DOR) a mechanism arrhythmogenesis in hypothermia. In addition, we investigated whether degree hypothermia, rate temperature change, cooling versus rewarming would alter hypothermia-induced Methods...
Ventricular tachycardia (VT)/ventricular fibrillation (VF) rearrest after successful resuscitation is common, and survival poor. A mechanism of VT/VF, as demonstrated in ex vivo studies, when repolarization alternans becomes spatially discordant (DIS ALT), which can be enhanced by impaired gap junctions (GJs). However, spontaneous DIS ALT-induced VT/VF has never been demonstrated, the effects GJ on ALT are unknown.
Abstract CD6 is a T cell surface glycoprotein that plays an important role in interactions of thymocytes with thymic epithelial cells and mature selected nonprofessional tissue APCs. We describe novel ligand (CD6L) 3A11 Ag distinct from the known CD6L (CD166). The protein expressed on derived human thymus, skin, synovium, cartilage, its expression enhanced by IFN-γ. mAbs directed against CD166 exhibit patterns binding to panel lines. Confocal microscopy shows both are at surface, these...
Although the majority of sudden cardiac arrests occur in patients with ischemic heart disease, effect therapeutic hypothermia on arrhythmia susceptibility during acute global ischemia is not well understood. While both and severe are arrhythmogenic, undergoing do have an increase arrhythmias, despite fact that most arrest setting ischemia. We hypothesized mild induced prior to myocardial reperfusion will a beneficial ischemia-related substrates.We developed model canine wedge preparation...
Acute cardiac ischemia induces conduction velocity (CV) slowing and block, promoting reentrant arrhythmias leading to sudden arrest. Previously, we found that mild hypothermia (MH; 32°C) attenuates ischemia-induced block CV in a canine model of early global ischemia. impairs cellular excitability the gap junction (GJ) protein connexin (Cx)43. We hypothesized MH prevented by preserving GJ expression localization. Canine left ventricular preparations at control (36°C) or (32°C) were subjected...
Background We designed an innovative porcine model of ischemia‐induced arrest to determine dynamic arrhythmia substrates during focal infarct, global ischemia from ventricular tachycardia or fibrillation (VT/VF) and then reperfusion the effect therapeutic hypothermia ( TH ) on resuscitation outcomes. Methods Results Anesthetized adult pigs underwent thoracotomy regional plunge electrode placement in left ventricle. Subjects were maintained at either control CT ; 37°C, n=9) (33°C, n=8). The...
Severe hypothermia (SH) is known to be arrhythmogenic, but the effect of therapeutic (TH) on arrhythmias unclear. It hypothesized that susceptibility Ca-mediated arrhythmia triggers would increased only by SH.Methods and Results:Spontaneous Ca release (SCR) resultant delayed afterdepolarizations (DADs) were evaluated optical mapping in canine wedge preparations during normothermia (N, 36℃), TH (32℃) or SH (28℃; n=8 each). The slope (amplitude/rise time) multicellular SCR (mSCR) events, a...
Onboard oxygen-generating systems (OBOGSs) provide increased inspired oxygen (FiO2) to mitigate the risk of neurologic injury in high altitude aviators. OBOGSs can deliver highly variable concentrations oscillating around a predetermined FiO2 set point, even when aircraft cabin is relatively stable. Steady-state exposure 100% evokes neurovascular vasoconstriction, diminished cerebral perfusion, and altered electroencephalographic activity. Whether non-steady-state leads similar outcomes...
Abstract Objective The purpose of this study was to determine the association a multi‐pronged treatment program in emergency department (ED) patients with an acute presentation opioid use disorder (OUD) on rate subsequent overdose (OD). This approach included ED‐initiated take‐home naloxone, prescription buprenorphine, and ED‐based peer support recovery program. Methods retrospective observational analysis adult presenting ED at large urban hospital system from November 1, 2017 March 17,...
Background: Cardiac rearrest post-return of spontaneous circulation (ROSC) is a critical concern in emergency care, as it associated with worse outcomes. Patient characteristics and arrest factors remain poorly understood, making predicting after out hospital cardiac (OHCA) challenging. Aim: To examine patterns, identify patient-specific risk for rearrest, assess the impact on patient Hypothesis: Patients that experience OHCA will have greater comorbidities, unfavorable characteristics,...