A5036694252- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Dermatology and Skin Diseases
- Microscopic Colitis
- IL-33, ST2, and ILC Pathways
- Immune responses and vaccinations
- Herpesvirus Infections and Treatments
- Vitamin D Research Studies
- Cytomegalovirus and herpesvirus research
- NF-κB Signaling Pathways
- Helicobacter pylori-related gastroenterology studies
Institute of Medical Microbiology and Hygiene
2019-2025
University Medical Center of the Johannes Gutenberg University Mainz
2019-2025
Johannes Gutenberg University Mainz
2019-2025
Center for Experimental and Clinical Infection Research
2015-2020
Helmholtz Centre for Infection Research
2015-2019
MyD88-mediated signaling downstream of Toll-like receptors and the IL-1 receptor family is critically involved in induction protective host responses upon infections. Although it known that MyD88-deficient mice are highly susceptible to a wide range bacterial infections, cell type-specific contribution MyD88 protecting against intestinal infection only poorly understood. In order investigate importance specific immune nonimmune types during infection, we employed novel murine knock-in model...
IL-17-producing Th17 cells mediate immune responses against a variety of fungal and bacterial infections. Signaling via NF-κB has been linked to the development maintenance cells. We analyzed role unusual inhibitor NF-κB, IκBNS, in proliferation effector cytokine production murine Our study demonstrates that nuclear IκBNS is crucial for cell generation. highly expressed cells; absence frequencies IL-17A-producing are drastically reduced. This was measured vitro under Th17-polarizing...
Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including helper (Th) and cytotoxic (Tc) associated with dysfunctional regulatory cells (Tregs). Acetyl-CoA carboxylase 1 (ACC1), rate-limiting enzyme fatty acid synthesis (FAS), directs cell fate decisions between Th17 Tregs thus could be promising therapeutic target for psoriasis treatment. Here, we demonstrate that targeting ACC1 in genetic ablation...
Human Cytomegalovirus (HCMV) is a widespread pathogen, infection with which can cause severe disease for immunocompromised individuals. The complex changes wrought on the host's immune system during both productive and latent HCMV are well known. Infected cells masked manipulated uninfected also affected; peripheral blood mononuclear cell (PBMC) proliferation reduced cytokine profiles altered. Levels increase of anti-inflammatory IL-10, may be important establishment infections required...
Abstract Infection with Clostridium difficile is one of the major causes health care acquired diarrhea and colitis. Signaling though MyD88 downstream TLRs critical for initiating early protective host response in mouse models C. infection (CDI). In intestine, expressed various tissues cell types, such as intestinal epithelium mononuclear phagocytes (MNP), including DC or macrophages. Using a genetic gain‐of‐function system, we demonstrate here that restricting functional signaling to...