A5088265856- Hip disorders and treatments
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Viral Infections and Vectors
- Spondyloarthritis Studies and Treatments
- Mosquito-borne diseases and control
- Dermatology and Skin Diseases
- Diabetes Treatment and Management
- Histone Deacetylase Inhibitors Research
- Malaria Research and Control
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Virology and Viral Diseases
Institute of Medical Microbiology and Hygiene
2023-2025
Johannes Gutenberg University Mainz
2023-2025
University Medical Center of the Johannes Gutenberg University Mainz
2023-2025
Princeton University
2025
Cancer Research Institute
2025
Ludwig Cancer Research
2025
National Cheng Kung University
2018-2022
Regulatory T cells (Tregs) are essential in maintaining immune tolerance and controlling inflammation. Treg stability relies on transcriptional post-translational mechanisms, including histone acetylation at the Foxp3 locus FoxP3 protein acetylation. Additionally, Tregs depend specific metabolic programs for differentiation, yet underlying molecular mechanisms remain elusive. We aimed to investigate role of acetyl-CoA carboxylase 1 (ACC1) stability, function regulatory (Tregs). used either...
Dengue virus (DENV) which infects about 390 million people per year in tropical and subtropical areas manifests various disease symptoms, ranging from fever to life-threatening hemorrhage even shock. To date, there is still no effective treatment for DENV disease, but only supportive care. nonstructural protein 1 (NS1) has been shown play a key role pathogenesis. Recent studies have that anti-DENV NS1 antibody can provide protection by blocking the DENV-induced disruption of endothelial...
Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including helper (Th) and cytotoxic (Tc) associated with dysfunctional regulatory cells (Tregs). Acetyl-CoA carboxylase 1 (ACC1), rate-limiting enzyme fatty acid synthesis (FAS), directs cell fate decisions between Th17 Tregs thus could be promising therapeutic target for psoriasis treatment. Here, we demonstrate that targeting ACC1 in genetic ablation...