A5023050101- Emergency and Acute Care Studies
- Nitric Oxide and Endothelin Effects
- Burn Injury Management and Outcomes
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Receptor Mechanisms and Signaling
- Color perception and design
- Olfactory and Sensory Function Studies
- PI3K/AKT/mTOR signaling in cancer
- Multisensory perception and integration
- Neuroscience and Neuropharmacology Research
- Injury Epidemiology and Prevention
Johns Hopkins Medicine
2020-2022
Johns Hopkins University
2020-2022
Stony Brook University
2018
The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory. We have previously shown that Thorase plays an important role in the internalization AMPARs from synaptic membrane. Here, we show N-methyl-d-aspartate (NMDAR) activation leads to increased S-nitrosylation N-ethylmaleimide-sensitive factor (NSF). stabilizes Thorase-AMPAR complexes enhances AMPAR interaction with protein-interacting...
The mechanistic target of rapamycin (mTOR) signals through the mTOR complex 1 (mTORC1) and 2 to maintain cellular organismal homeostasis. Failure finely tune activity results in metabolic dysregulation disease. While there is substantial understanding molecular events leading mTORC1 activation at lysosome, remarkably little known about what terminates signaling. Here, we show that AAA + ATPase Thorase directly binds mTOR, thereby orchestrating disassembly inactivation mTORC1. disrupts...
Attrition between emergency department discharge and outpatient follow-up is well documented across a variety of pediatric ailments. Given the importance medical care lack related research in burn populations, we examined sociodemographic factors characteristics associated with adherence among patients. A retrospective review records was conducted on patient data extracted from registry database at an urban academic children's hospital over 2-year period (January 2018-December 2019). All...