A5019715911- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Genetic Syndromes and Imprinting
- Genomics and Chromatin Dynamics
- Amyotrophic Lateral Sclerosis Research
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Autism Spectrum Disorder Research
- ATP Synthase and ATPases Research
- Neurogenetic and Muscular Disorders Research
- Prion Diseases and Protein Misfolding
- Developmental Biology and Gene Regulation
University of Edinburgh
2024-2025
UK Dementia Research Institute
2024-2025
MRC Centre for Regenerative Medicine
2025
Helmholtz Zentrum München
2016
NTL Institute for Applied Behavioral Science
2011
Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal differentiation when expressed in neural progenitor cells. The mechanisms by which proneural activate neurogenesis--and, particular, the that they regulate--however, mostly unknown. We performed a genome-wide characterization of transcriptional targets embryonic brain stem cultures location analysis expression profiling embryos overexpressing or mutant for Ascl1. wide range molecular cellular functions...
In order to understand whether early epigenetic mechanisms instruct the long-term behavior of neural stem cells (NSCs) and their progeny, we examined Uhrf1 (ubiquitin-like PHD ring finger-1; also known as Np95), it is highly expressed in NSCs developing brain rapidly down-regulated upon differentiation. Conditional deletion cerebral cortex resulted rather normal proliferation neurogenesis but severe postnatal neurodegeneration. During development, lead global DNA hypomethylation with a...
The Fragile X Messenger Ribonucleoprotein (FMRP) is an RNA binding protein that regulates the translation of multiple mRNAs and expressed by neurons glia in mammalian brain. Loss FMRP leads to fragile syndrome (FXS), a common inherited form intellectual disability autism. While most research has been focusing on neuronal contribution FXS pathophysiology, role glia, particularly oligodendrocytes, largely unknown. individuals are characterized white matter changes, which imply impairments...
Imprinting is an epigenetic mechanism that restrains the expression of about 100 genes to one allele depending on its parental origin. Several imprinted are implicated in neurodevelopmental brain disorders, such as autism, Angelman, and Prader-Willi syndromes. However, how these regulated during neural development poorly understood. Here, using single double KO animals for transcription factors Neurogenin2 (Ngn2) Achaete-scute homolog 1 (Ascl1), we found a specific subset controlled by...
The Fragile X Messenger Ribonucleoprotein (FMRP) is an RNA binding protein that regulates the translation of multiple mRNAs and expressed by neurons glia in mammalian brain. Loss FMRP leads to Syndrome (FXS), a common inherited form intellectual disability autism. While most research has been focusing on neuronal contribution FXS pathophysiology, role glia, particularly oligodendrocytes, largely unknown. individuals are characterised white matter changes which imply impairments...