A5077545715- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Muscle Physiology and Disorders
- Ion Channels and Receptors
- Glaucoma and retinal disorders
- GDF15 and Related Biomarkers
- Histone Deacetylase Inhibitors Research
Aichi Medical University
2022-2024
Intraocular pressure (IOP), a key factor in glaucoma development, is regulated by aqueous humor (AH) dynamics, with inflow from the ciliary body and outflow through trabecular meshwork (TM). IOP has circadian rhythm entrained sympathetic norepinephrine (NE) superior cervical ganglion. Herein, we investigated its underlying regulatory mechanisms TM. Through comprehensive gene expression analysis of human TM cells mouse eyes, identified 18 genes upregulated NE stimulation, including small...
The transient receptor potential melastatin type 2 (TRPM2) channel is a non-selective cation that has high Ca2+ permeability. TRPM2 sensitive to warm temperatures and expressed in cells tissues are maintained at core body temperature. activity also regulated by endogenous factors including redox signalling, cytosolic adenosine diphosphate ribose. As result of its wide expression function temperature, these could regulate temperature under physiological pathophysiological conditions. We...
Myogenesis is regulated mainly by transcription factors known as Myogenic Regulatory Factors (MRFs), and the affected epigenetic modifications. However, regulation of myogenesis poorly understood. Here, we focused on epigenomic modification enzyme, PHF2, which demethylates histone 3 lysine 9 dimethyl (H3K9me2) during myogenesis. Phf2 mRNA was expressed myogenesis, PHF2 localized in nuclei myoblasts myotubes. We generated knockout C2C12 using CRISPR/Cas9 system analyzed global transcriptional...
Mammalian circadian rhythms are driven by the transcriptional-translational feedback loop of clock genes in hypothalamic suprachiasmatic nucleus. However, chronic methamphetamine treatment induces activity arrhythmic animals with nucleus lesions or gene deletions. Activation dopaminergic neurotransmission is considered to induce rhythms. Adenosine antagonizes actions dopamine at heteromers and adenosine receptors (dopamine D1 A1 receptors, D2 A2A receptors). In this study, we that inhibition...