A5058361723- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Sensors
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Electrochemical sensors and biosensors
- Pesticide Residue Analysis and Safety
- Pharmacological Effects and Assays
- Electrochemical Analysis and Applications
- Spectroscopy and Chemometric Analyses
- Diabetes Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Cholinesterase and Neurodegenerative Diseases
- Hormonal and reproductive studies
- Advanced Chemical Sensor Technologies
- Mass Spectrometry Techniques and Applications
- Anesthesia and Pain Management
- Protein Interaction Studies and Fluorescence Analysis
- Natural Antidiabetic Agents Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Inflammatory mediators and NSAID effects
- Biosensors and Analytical Detection
- Receptor Mechanisms and Signaling
- Epilepsy research and treatment
- Biosimilars and Bioanalytical Methods
- Estrogen and related hormone effects
Cairo University
2014-2023
October 6 University
2018-2023
A solid-state ion-selective electrode for detection of tramadol has been fabricated utilizing polyaniline nanoparticles as an ion-to-electron transducer layer. The (PANI) were synthesized by the micellar emulsion chemical polymerization method and mean particle size was ∼8 nm. inclusion PANI layer between ionophore-doped PVC membrane solid contact electrodes carried out to improve stability electrical signal. Both short long-term studies performed compared free electrodes. Furthermore,...
Sofosbuvir and ledipasvir are the first drugs in a combination pill to treat chronic hepatitis C virus. Simple, sensitive, rapid spectrophotometric methods presented for determination of sofosbuvir their combined dosage form. These were based on direct measurement at 333 nm (due lack interference sofosbuvir) over concentration range 4.0-14.0 µg/mL, with mean recovery 100.78 ± 0.64%. was determined, without prior separation, by third-derivative values 281 nm; derivative ratio 265.8 utilizing...
Two fast, accurate and selective stability-indicating methods were developed validated for the simultaneous determination of bisoprolol, perindopril three their possible degradation products. The first proposed method was a gradient reversed phase-high-performance liquid chromatography (HPLC) method, whereas second capillary electrophoresis method. structures obtained products elucidated using infrared mass spectrometry. They also confirmed to be either drug impurity in British Pharmacopoeia...
The use of performance-enhancing drugs is prohibited in sports competitions according to the World Anti-Doping Agency (WADA) regulations. Here, ATR-FTIR spectroscopy coupled with a partial least squares regression (PLSR) chemometric tool was used for detection misuse such substances. Bambuterol and its metabolite terbutaline have been included list doping agents. Therefore, we bambuterol as models accurate simultaneous qualitative quantitative analysis human urine samples. method...
Abstract Etoricoxib (ETO), Paracetamol (PCM), and two toxic impurities for impurity K (4-aminophenol (PAP)) E (para-hydroxy acetophenone (PHA)) were separated using a simple selective HPLC method that was tested the first time. PCM is commonly used analgesic antipyretic medication has recently been incorporated into COVID-19 supportive treatment. Pharmaceuticals containing in combination with other analgesic-antipyretic drugs like ETO help to improve patient compliance. The studied on GL...
The multivariate models that are used for spectral data analysis have many beneficial applications, and one of the important applications is drugs their impurities. Three Chemometrically-assisted spectrophotometric been proposed validated. Partial Least Squares (PLS), Artificial Neural Networks (ANN), Multivariate Curve Resolution-Alternating (MCR-ALS). advanced chemometric were applied to resolve significantly overlapping spectra Etoricoxib (ETO) Paracetamol (PCM), along with impurities PCM...
Four sensitive and selective stability-indicating methods for the determination of bupropion hydrochloride in presence its alkaline degradates, related impurity, 3-chlorobenzoic acid, pharmaceutical formulation were developed. Method A is an isocratic reversed phase HPLC, good separation between hydrochloride, degradates impurity was achieved using a mobile 1.2% w/v ammonium dihydrogen phosphate pH 4.5 acetonitrile (80:20, v/v) detection at 210 nm. B based on first derivative (D1)...
Stability indicating HPLC and TLC-densitometric methods for the determination of hydroquinone, tretinoin, fluocinolone acetonide, their degradation products preservatives.
The experimental design extracts valuable information about the main effects and interactions from least number of experiments. current work constructs a solid-state sensor for selective assay Ondansetron (OND) in pharmaceutical dosage form plasma samples. During optimization, Design Expert® statistical package constructed custom 15 sensors with different recipes. We fed software experimentally observed performance parameters each (slope, LOQ, correlation coefficient, selectivity coefficient...