Abstract Butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) are two antioxidants that have been extensively used in many applications. Both well known for their debatable health risks due to multiple intake sources. Therefore, conservative limits set them different regulations adapted the matrices which they exist. Here we present a simple spectrofluorimetric method determination of BHT BHA based on native fluorescence synchronous scanning mode. The type solvent interval...

Abstract Nowadays, scientists are currently attempting to lessen the harmful effects of chemicals on environment. Stability testing identifies how a drug’s quality changes over time. The current work suggests first and sustainable differential pulse voltammetry technique for quantifying difluprednate (DIF) as an anti-inflammatory agent in presence its alkaline degradation product (DEG). optimum conditions developed method were investigated with glassy carbon electrode scan rate 100 mV s −1 ....

"Green analytical chemistry" (GAC) is a vital area towards the concept of sustainability. As consequence widespread application HPLC in drug-related investigations and resulting contamination environment with organic solvents questions have been raised about toxicity/greenness ecosystem. Traditional separation technologies yield approximately 50 mL waste per data point. To this end, pharmaceutical community continues to search for greener opportunities markedly reduce amount produced move...

Waste resulting from edible plants is considered one of the best sources valuable phytochemicals. A promising approach for using these appreciated wastes extracting precious medically important constituents, example, free quercetin. Two new cost-effective and green extraction methods are introduced in present study: ultrasound-assisted glycerol (UAGE) microwave-assisted (MAE). These protocols optimized factorial design to define highest yield extraction, HPLC-UV at 370 nm was used as a...

Abstract Preserving the environment, reducing amount of waste resulting from chemical trials, and energy consumed have currently become a pivotal global trend. An analytical quality by design (AQbD) based eco-friendly TLC-densitometric method was implemented for quantifying two antihypertensive agents, captopril (CPL) hydrochlorothiazide (HCZ), along with their impurities; disulphide (CDS), chlorothiazide (CTZ) salamide (SMD). The target profile (ATP) first identified, followed selecting...

Abstract The development of a newly fabricated ion-selective electrode (ISE) solid-contacted type for the determination prucalopride succinate represents significant advancement in analytical chemistry, particularly context green chemistry principles. optimization process involved numerous trials to ensure selection cation exchanger and ionophore that offer high sensitivity selectivity succinate. Through these trials, sodium tetrakis was identified as most suitable exchanger, while calix [8]...

Lidocaine poses challenges when it comes to direct spectrophotometric measurement due the lack of sharp peak within its spectra in zero-order. This a distinct makes difficult accurately quantify lidocaine using traditional methods. In our study, different univariate and multivariate techniques have been established their validity has assessed for determination mixture HCl (LD), Oxytetracycline (OTC) together with LD carcinogenic impurity [2,6- dimethylaniline] DMA. was resolved from other...

Abstract Irinotecan (IRNO) is used as a first line anticancer drug for the treatment of mainly metastatic colorectal cancer. Globally, cancer sorted second cause death. It important to analyze drugs carefully and rapidly in different pharmaceutical formulations. The purpose our work was develop validate green, simple, cost-effective, portable ion-selective electrodes quantitation IRNO formulation, spiked human plasma with other co-administrated antiemetic such Granisetron Ondansetron. Liquid...

A cost-effective, selective, sensitive, and operational TLC-densitometric approach has been adapted for the concurrent assay of Hydroxyzine Hydrochloride (HYX), Ephedrine (EPH), Theophylline (THP) in their pure powder pharmaceutical forms. In innovative approach, HYX, EPH, THP were efficaciously separated quantified on a 60F254 silica gel stationary phase with chloroform-ammonium acetate buffer (9.5:0.5, v/v) adjusted to pH 6.5 using ammonia solution as mobile liquid system UV detection at...

Three sensitive, selective and reproducible stability-indicating methods are presented for determination of nitazoxanide (NTZ), a new anti-protozoal drug, in presence its degradation products. Method A utilizes the first derivative ratio spectra spectrophotometry by measurement amplitude at 364.4 nm using one products as divisor. B is chemometric-assisted spectrophotometry, where principal component regression (PCR) partial least squares (PLS) were applied. These two approaches successfully...

Two specific, sensitive, and precise stability-indicating chromatographic methods have been developed, optimized validated for determination of perindopril arginin (PER) amlodipine besylate (AML) in their mixtures the presence degradation products. The first method was based on thin-layer chromatography (TLC) combined with densitometric separated bands. Adequate separation achieved using silica gel 60 F254 TLC plates ethyl acetate-methanol-toluene-ammonia solution, 33% (6.5:2:1:0.5 by...

Abstract A sensitive and highly selective stability-indicating gradient HPLC method was developed validated for simultaneous determination of clorsulon (CLO) ivermectin (IVM) in the presence their degradation products. The drugs were subjected to different stress conditions, including acid alkaline hydrolysis, oxidative, thermal, photolytic forced degradation. robustness proposed assessed using Plackett-Burman experimental design, factors affecting system performance defined, nonsignificant...

An economical & eco-friendly spectrofluorometric method has been developed for the determination of prucalopride succinate (PRU) in human urine on basis drug's native fluorescence. The type solvent and wavelengths excitation emission have carefully selected optimal experimental conditions. In deionized water, fluorescence intensity was measured at λ 362 nm upon 310 nm. This bio-validated carried out using 30uL without any preliminary steps. calibration curve shows a linear relationship...

Abstract Pholcodine and guaiacol are widely used together in pharmaceutical syrups for cough treatment. On the other hand, Ultra Performance Liquid Chromatographic technique is characterized by having power of increasing chromatographic efficiency decreasing run time compared to traditional High one. In this work, was exploited simultaneous determination pholcodine, along with three impurities, namely; impurity A, B, E. Good separation achieved employing Agilent Zorbax C8 column (50 × 2.1...