Abstract Butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) are two antioxidants that have been extensively used in many applications. Both well known for their debatable health risks due to multiple intake sources. Therefore, conservative limits set them different regulations adapted the matrices which they exist. Here we present a simple spectrofluorimetric method determination of BHT BHA based on native fluorescence synchronous scanning mode. The type solvent interval...

A new simple spectrophotometric method was developed for the simultaneous determination of drugs with interfering spectra in binary mixtures without previous separation. The is based on a modification ratio subtraction method. This enabled wider range application. proposed difference applied brimonidine and timolol laboratory prepared mean percentage recoveries 100.40±2.29 101.23±1.30 respectively, their pharmaceutical formulation 101.08±0.44 100.66±0.52 respectively. suggested validated...

The introduction of sustainable development concepts to analytical laboratories has recently gained interest, however, most conventional high‐performance liquid chromatography methods do not consider either the effect used chemicals or amount produced waste on environment. aim this work was prove that can be replaced by greener ones with same parameters. suggested were designed so they neither use nor produce harmful and minimum in routine analysis without harming This achieved using green...

An innovative spectrophotometric method was developed for simultaneous determination of compounds with interfering spectra in binary mixtures without previous separation, showing significant advantages over the conventional methods regarding minimal data manipulation and applicability. The proposed applied retinoic acid hydroquinone laboratory-prepared mean percentage recoveries 100.13 ± 0.31 99.99 0.04, respectively, their pharmaceutical formulation 0.86 100.07 0.58, respectively. validated...

Sofosbuvir is a novel direct acting antiviral agent against hepatitis C virus. In the present work, rapid, specific and reproducible isocratic reversed phase high performance liquid chromatography (RP-HPLC) method has been developed validated for determination of sofosbuvir in presence its stressed degradation products. Sobosbuvir was subjected to hydrolysis (acidic, alkaline neutral), oxidation, photolysis thermal stress, as per international conference on harmonization (ICH) conditions....

Abstract Gold and silver nanoparticles have witnessed increased scientific interest due to their colourful colloidal solutions exceptional applications. Comparing the localized surface plasmon resonance (LSPR) of gold is crucial for understanding optimizing optical properties. This comparison informs design highly sensitive plasmonic sensors, aids in selecting most suitable applications like surface-enhanced infrared spectroscopy (SEIRA) biomedical imaging, guides choice between based on...

The present study considered the pharmacokinetic evaluation of empagliflozin after administration to Egyptian volunteers, and results were compared with other ethnic populations. FDA recognizes that standard methods defining racial subgroups are necessary compare across studies assess potential subgroup differences. design was as an open labeled, randomized, one treatment, period, single dose study. main parameters estimated Cmax, Tmax, t1/2, elimination rate constant, AUC0-t AUC0-inf....

Thin-layer chromatography (TLC) is an effective and simple technique for screening, evaluating, quantifying low-quality counterfeit pharmaceutical products. Smartphones have recently been used as accessible, cheap, portable detectors that can replace more complicated analytical detectors. In this work, we developed a sensitive TLC method utilizing smartphone charged-coupled device (CCD) camera not only to verify quantify some gastrointestinal tract drugs, namely, loperamide hydrochloride...

This work describes the fabrication of solid-contact potentiometric sensor to determine antiviral drug; tenofovir disoproxil fumarate. Screen-printed carbon electrodes have been selected as being a disposable substrate material. Ion sensing membrane is based on Polyvinyl chloride (PVC) polymer that was impregnated with calix [6] arene an ionophore for facilitating transferring drug interest from sample phase into through decreasing Gibbs free energy transfer. We applied graphene...

The electropolymerized molecularly imprinted polymers (MIP) have enabled the utilization of various functional monomers with superior selective recognition target analyte template. Methyldopa is an attractive synthetic dopamine analogue which has phenolic, carboxylic, and aminic groups. In this research, methyldopa was exploited to fabricate MIPs, for detection sofosbuvir (SFB), by a simple electropolymerization step onto disposable pencil graphite electrode (PGE) substrate. interaction...

Abstract Two methods were developed for separation and quantitation of amlodipine (AML) atorvastatin (ATV) in the presence their acidic degradation products. The first method was a simple isocratic RP-HPLC while second capillary electrophoresis (CE). Degradation products obtained by hydrolysis two drugs structures elucidated time IR MS spectra. did not interfere with determination either drug assays therefore stability-indicating. linearity proposed established over ranges 1-50 μg mL -1 AML...

Amantadine HCl (AMN) is a well-known antiviral agent. Chemically, AMN chromophore privation leads to the absence of UV-absorbance, condition that hinders direct spectrophotometric or simple chromatographic determination using common detectors without prior derivatization steps. In this work, an environmentally friendly ion selective electrode (ISE) method was developed for AMN, and measurements were carried out directly in aqueous solution sample pretreatment PVC-membranes fabricated...

In pharmaceutical industry and clinical applications, finding real-time analyzers with minimal sample preparation is a good aim. The presented solid-contact sensor offers reasonable tool for selective, sensitive eco-friendly analysis.