This work implements a combined experimental approach of analytical quality-by-design and green chemistry to develop an HPLC method for simultaneous determination the two thalassemia drugs, deferasirox deferiprone in biological fluid first time.

The study presents a first electrochemical method for the determination of immunomodulator drug Baricitinib (BARI), crucial in managing COVID-19 patients requiring oxygen support. A unique electrode was developed by modifying graphite carbon nickel nanoparticles (NiNPs) with functionalized multiwalled nanotubes (f.MWCNTs), resulting nanohybrids tailored highly sensitive BARI detection. Comparative analysis revealed superior electrocatalytic performance nanohybrid-modified over unmodified...

The introduction of sustainable development concepts to analytical laboratories has recently gained interest, however, most conventional high‐performance liquid chromatography methods do not consider either the effect used chemicals or amount produced waste on environment. aim this work was prove that can be replaced by greener ones with same parameters. suggested were designed so they neither use nor produce harmful and minimum in routine analysis without harming This achieved using green...

Abstract Ion-selective electrodes (ISEs) are used in diverse environmentally-friendly analytical applications. In this study, we developed and assessed potentiometric sensing membranes for the selective determination of benzydamine hydrochloride (BZ) using two distinct ISE designs: solid contact conventional liquid sensors. The responses over a wide BZ concentration range (1.00 × 10−7 – 1.00 10−2 M) previously mentioned sensors were fast, linear, stable. fabricated demonstrated effective...

Abstract Highly sensitive spectrofluorimetric methods were developed for the quantitative estimation of formoterol fumarate dihydrate (FFD) and fluticasone propionate (FP) in both authentic raw materials marketed dosage forms using a micellar-enhanced approach. The proposed are based on determination FP presence FFD first derivative emission spectrofluorimetry. peak amplitude spectra formed micellar fluorescence was measured at 465 nm after excitation 236 (λ max FP).The second method...

Abstract Letrozole (LTZ) is an established first hormonal treatment for breast cancer, yet it was found to be highly susceptible degradation in alkaline medium due the presence of cyano phenyl group. Consequently, three stability-indicating spectrophotometric manipulations LTZ quantification its alkali-induced products were developed time; ensuring methods’ simplicity, sensitivity and accuracy. The method Second derivative (D 2 ) by recording peak amplitude drug at 226.8 nm. second Ratio...

Abstract Three accurate, simple, and precise chemometric techniques, principal component regression (PCR), partial least squares (PLS), backward interval (biPLS) were used to resolve the severely overlapped UV spectra of miconazole nitrate (MIC) Lidocaine hydrochloride (LDC) along with toxic impurity LDC; dimethyl aniline (DMA) two inactive ingredients; methyl paraben (MTP) saccharin sodium (SAC). The concentration ranges developed models found be (2.40–12.00 µg/mL) for LDC MIC, (1.50–7.50...

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Analysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study different novel and techniques resolution severely overlapping spectra were presented in this work utilizing isosbestic points present absorption spectra, normalized as divisor dual wavelengths. quaternary drotaverine (DRO), caffeine (CAF), paracetamol (PCT) para-aminophenol (PAP) was taken an example...

Comtrex® tablets composed of paracetamol, pseudoephedrine and brompheniramine are widely used for relieving symptoms related to common cold. This study has overcome the challenging dosage form ratio (250:15:1) proposed chromatographic methods analyzing ternary combination were utilized displaying different apparatus, solvents sensitivity ranges. Three namely thin layer chromatography (TLC), high performance liquid with ultra-violet detection (HPLC-UV) ultra-performance coupled tandem mass...