A5002898704- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Multicomponent Synthesis of Heterocycles
- Catalytic C–H Functionalization Methods
- Synthesis of Indole Derivatives
- Sulfur-Based Synthesis Techniques
- Synthesis and Reactions of Organic Compounds
Ural Federal University
2022-2025
Azolo[1,5-a]pyrimidine is one of the most promising scaffold in development potent anticancer agents. However, structural motifs such are often limited to 5,7-substituted azolo[1,5-a]pyrimidines due well-known synthesis route and existing drugs (e.g., Dinaciclib) on their basis. To expand understanding rare substituent combinations this research field, a new series 7-amino-5-aryl-6-cyanoazolo[1,5-a]pyrimidines with various azole moieties were synthesized studied A172, Rd, Hos HEK293 cell...
A plethora of 6-(hetero)aryl C-C and C-N bonded tacrine analogues has been made accessible by employing palladium mediated (Suzuki-Miyaura, Heck, Sonogashira, Stille Buchwald) cross-coupling reactions, starting from either halogenated or borylated residues. The successful use Pd(dppf)Cl2·CH2Cl2 as a common catalytic system in realizing all these otherwise challenging transformations is the highlight our optimized protocols. thus synthesized allow available chemical space around C-6 this...
1-Butane sulfonic acid-3-methylimidazolium tosylate, [BSMIM]OTs, is a remarkable catalyst for the cascade synthesis of coumarin-functionalized indole derivatives via tandem cyclization reaction aniline and phenylglyoxal monohydrate.