A5026251040- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fluorine in Organic Chemistry
- Chemical Reaction Mechanisms
- Quinazolinone synthesis and applications
- Chemical Reactions and Mechanisms
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Heterocycles
- Synthesis of β-Lactam Compounds
- Biochemical and Molecular Research
- Cancer therapeutics and mechanisms
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Chemical synthesis and pharmacological studies
- Adenosine and Purinergic Signaling
- Influenza Virus Research Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Reactions and Isotopes
- Lanthanide and Transition Metal Complexes
Ural Federal University
2016-2025
Institute of Organic Synthesis
2008-2019
Ural Branch of the Russian Academy of Sciences
2004-2019
Peoples' Friendship University of Russia
2015
Russian Academy of Sciences
2011
N.D. Zelinsky Institute of Organic Chemistry
2007-2010
A.E. Arbuzov Institute of Organic and Physical Chemistry
2005-2010
Ural State Forestry Engineering University
2004-2006
Kirov State Medical Academy
1977-1991
The Research Institute for Fertilizers and Insectofungicides
1989
Azolo[1,5-a]pyrimidine is one of the most promising scaffold in development potent anticancer agents. However, structural motifs such are often limited to 5,7-substituted azolo[1,5-a]pyrimidines due well-known synthesis route and existing drugs (e.g., Dinaciclib) on their basis. To expand understanding rare substituent combinations this research field, a new series 7-amino-5-aryl-6-cyanoazolo[1,5-a]pyrimidines with various azole moieties were synthesized studied A172, Rd, Hos HEK293 cell...
Hypercytokinemia, or cytokine storm, is one of the severe complications viral and bacterial infections, involving release abnormal amounts cytokines, resulting in a massive inflammatory response. Cytokine storm associated with COVID-19 sepsis high mortality rate by developing epithelial dysfunction coagulopathy, leading to thromboembolism multiple organ syndrome. Anticoagulant therapy an important tactic prevent thrombosis COVID-19, but recent data show incompatibility modern direct oral...
Fluoroquinolones are an important class of modern and efficient antibacterial drugs with a broad spectrum activity. Levofloxacin (the optically active form ofloxacin) is one the most promising fluoroquinolone drugs, its activity substantially higher than other family. Earlier, in Postovsky Institute Organic Synthesis, UB RAS, original method levofloxacin synthesis was developed, now pilot batch drug being prepared. Bacterial DNA gyrase specific target fluoroquinolones; hence, study...
Acute lung injury remains a challenging clinical condition, necessitating the development of novel, safe and efficient treatments. The prevention macrophage M1-polarization is viable venue to tackle excessive inflammation. We performed phenotypic screening campaign identify azolopyrimidine compounds that effectively inhibit LPS-induced NO synthesis interleukin 6 (IL-6) secretion. identified lead compound 9g inhibits IL-6 secretion with IC50 3.72 µM without apparent cytotoxicity minimal...
Today, cancer is one of the most widespread and dangerous human diseases with a high mortality rate. Nevertheless, search application new low-toxic effective drugs, combined timely diagnosis diseases, makes it possible to cure types tumors at an early stage. In this work, range polysubstituted 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines was extended. The structure all obtained compounds confirmed by data 1H, 13C NMR spectroscopy, IR elemental analysis. These were evaluated against recombinant...
A number of new 5,6-disubstituted benzimidazoles have been prepared and their substrate properties for recombinant <i>E. coli</i> purine nucleoside phosphorylase (PNP; the product <i>deoD</i> gene) in transglycosylation reaction were investigated. The heterocyclic bases showed good activity PNP ribo- 2′-deoxyribonucleosides synthesized. predominant (OMe OEt) or exclusive (O<i>i</i>-Pr, morpholino, <i>N</i>-methylpiperazino) formation 5-substituted...
A series of 5,6-disubstituted benzimidazole nucleosides, obtained earlier, did not show any significant antiviral activity at relatively low cytotoxicity in vitro. In the course our research we have succeeded introducing an additional fluorine atom into ring system. new 4,6-difluorobenzimidazoles, bearing various groups (fluoro-, methoxy-, ethoxy-, morpholino-, and pyrrolidino-) 5-position benzene ring, been synthesized. All these compounds proved to be substrates for recombinant <i>E....
Abstract The review surveys the recently obtained data on synthesis of fluorinated benzazoles and benzazines. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:579–594, 2006; Published online in InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20281
1-(2′-Deoxy-2′-fluoro-β-<sc>d</sc>-arabinofuranosyl)benzimidazoles containing 4,6-difluoro-, 4,5,6-trifluoro-, 5-fluoro-6-methoxy-, and 5-methoxy-4,6-difluorobenzimidazole fragments were synthesized by using purine nucleoside phosphorylase-catalyzed chemoenzymatic approach. As expected, enzymatic synthesis of nucleosides proceeds in lower yields target compounds comparison with the ribo- 2′-deoxyribobenzimidazoles (40–55% vs 60–90%). The obtained tested against herpes simplex virus type 1,...
Dihydrothiazoles and thiazoles were synthesized by the reaction of monothiooxamides containing allylamine propargylamine fragments with halogens in ionic liquids.