A5042724885- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Erythropoietin and Anemia Treatment
- Hormonal Regulation and Hypertension
- Neurological and metabolic disorders
- Parathyroid Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Acute Kidney Injury Research
- Sodium Intake and Health
- Pharmacological Effects and Toxicity Studies
- Acute Ischemic Stroke Management
- Renal Diseases and Glomerulopathies
- Hemodynamic Monitoring and Therapy
- Cardiac electrophysiology and arrhythmias
- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Intracerebral and Subarachnoid Hemorrhage Research
- Renin-Angiotensin System Studies
- Ion Transport and Channel Regulation
- Vitamin D Research Studies
- Muscle and Compartmental Disorders
- Neurological Disorders and Treatments
- Urticaria and Related Conditions
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
Aso Iizuka Hospital
2021-2025
Kyushu University
2013-2023
Fukuoka University
2018
Kyushu University Hospital
2018
Japanese Red Cross Fukuoka Hospital
2016
Fukuoka Dental College
2016
Abstract Vascular calcification is closely related to cardiovascular morbidity and mortality. Accumulating data indicate that oxidative stress associated with dysfunction of various organs, including diseases in chronic kidney disease (CKD). However, it remains undetermined if induced by uremia promotes arterial medial calcification. The present study investigated the role pathogenesis uremic rats. Rats adenine-rich diet progressively developed calcification, which was accompanied...
Accumulating evidence suggests that mineralocorticoid receptor (MR) blockade effectively reduces proteinuria in diabetic nephropathy although the renin-angiotensin-aldosterone system is generally suppressed diabetes. The present study was designed to confirm antiproteinuric effect of MR rats and elucidate its mechanism.The investigated whether inhibits hyperglycemia-induced podocyte injury, focusing on involvement reactive oxygen species (ROS) production, cultured podocytes. Sprague-Dawley...
The contribution of serum phosphate levels to stroke risk in dialysis patients remains unclear. present study aimed elucidate the respective association between and brain hemorrhage or infarction undergoing hemodialysis.A total 3437 hemodialysis were followed up for a median 3.9 years. primary outcome was occurrence infarction. Patients divided into 4 groups based on their baseline (Q1-Q4). Stroke estimated using Cox proportional hazards model.During follow-up period, 75 experienced 139...
Chronic kidney disease (CKD) is frequently associated with uremic encephalopathy and cognitive impairment. Recent studies have demonstrated that cerebral oxidative stress contributes to dysfunction. Although has been reported increase in the rat brain, relationship between increased impairment uremia unclear. In present study, effects of tempol (TMP), an antioxidant drug, were investigated mice. CKD was induced male C57BL/6 mice (n = 8) by left nephrectomy 2/3 electrocoagulation right renal...
Background & Objectives It is well known that cognitive impairment in patients with chronic kidney disease (CKD) characterized by executive dysfunction, rather than memory although the precise mechanism of this remains to be elucidated. The purpose present study examine correlation between gray matter volume (GMV) and function CKD patients. Design, Setting, Participants, Measurements This cross-sectional recruited 95 non-dialysis-dependent (NDD-CKD) no history cerebrovascular disease, who...
Previous studies have shown that hyponatremia is associated with greater mortality in hemodialysis (HD) patients. However, there been few reports regarding the importance of change serum sodium (SNa) concentration (ΔSNa) during dialysis sessions. To investigate relationships pre-dialysis and ΔSNa a session mortality, we analyzed data from national registry Japanese patients end-stage kidney disease.We identified 178,114 database who were undergoing HD 3 times weekly. The study outcome was...
Background: Shared decision-making (SDM) is a key process in selecting renal replacement therapy (RRT). This study analyzed SDM perceptions, preferences, and patient- facility-level factors influencing among Japanese patients with chronic kidney disease (CKD) who selected RRT. Methods: We 475 adult CKD from 49 medical facilities. awareness recognition, preferences for timing frequency, discussion content, desired professional involvement were assessed. Patient- associated perceptions...
Hemodialysis patients who receive vitamin D receptor activator (VDRA) reportedly have better survival after infection than those do not. However, the optimal route of its administration for minimizing death from remains unclear. This prospective cohort study aimed to compare effectiveness oral versus intravenous VDRA regarding infection-related mortality in 3372 hemodialysis patients. Eligible subjects were divided into following three groups by VDRA: (n = 1868), 492) and not administered...
The contribution of the hemoglobin concentration to incidence hemorrhagic or ischemic stroke in patients undergoing hemodialysis is unclear.In total, 3436 prevalent were followed up for 4 years. primary outcome was first development stroke. baseline divided into quartiles [hemoglobin (g/dL): Q1, ≤9.7; Q2, 9.8-10.5; Q3, 10.6-11.1; Q4, ≥11.2]. association between and each type examined using Kaplan-Meier method a Cox proportional hazards model.During follow-up period, 76 (2.2%) developed 139...
Aim: The incidence of sudden death and its risk factors in patients on hemodialysis remain unclear. This study aimed to clarify the Japanese hemodialysis.
Background Controversy exists regarding the renoprotective effect of erythropoiesis-stimulating agent (ESA) in progressive chronic kidney disease (CKD) with renal anemia. In this study, we examined whether ESA therapy has a CKD. Methods The subjects retrospective observational study were 68 non-dialysis dependent CKD patients We compared progression rate (PR), defined by slope linear regression line estimated glomerular filtration rate, measured during 6 months just before and after start...
Gadolinium (Gd)-based contrast media were introduced as alternatives to iodinated for magnetic resonance imaging (MRI). Although originally thought be non-nephrotoxic, Gd-based have recently been reported associated with acute kidney injury. The underlying mechanism of Gd-induced renal injury is not completely understood. We report an 80-year-old patient buccal mucosa cancer whom MRI agent was conducted 3 times within weeks. developed rapid deterioration preexisting insufficiency, and uremic...
Abstract: Orthostatic hypotension (OH) after hemodialysis (HD) is a serious complication, as it causes various neurological symptoms and even ischemic brain damage. The aim of the present study was to evaluate effects antihypotensive agents, midodrine hydrochloride (MID) l ‐threo‐3,4‐dihydroxyphenylserine (L‐DOPS), on OH HD. We measured systolic blood pressure (SBP) cerebral flow velocity in middle artery (MCVm, by transcranial Doppler sonography), patients with during 5‐min 60‐degree...
Abstract The influence of pre-dialysis blood pressure (BP) on the prognosis hemodialysis (HD) patients is still inconclusive. A total 3436 HD were prospectively followed up for 4 years. divided into quintiles systolic BP (SBP) and diastolic (DBP) levels [mm Hg]: Quintile 1 (Q1), SBP <134, DBP <66; Q2, 134 to 147, 66 72; Q3, 148 158, 73 79; Q4, 159 171, 80 85; Q5, ≥172, ≥86. association between outcomes examined using a Cox proportional hazards model. During 4-year follow-up period, 564...
Abstract Extended catheters with an upper abdominal exit‐site (UAE) are reportedly associated a lower incidence of peritoneal dialysis (PD)‐related infections. However, little information about the optimal catheter configuration for UAE is available. In this nonrandomized multicenter trial, 147 consecutive cases involving either conventional straight (CS; 80 cases) or extended swan‐neck (SN; 67 were analyzed to compare and tunnel infections (ESTI), peritonitis, survival. The ESTI‐free...