A5071576766- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Muscle and Compartmental Disorders
- Advanced Glycation End Products research
- Blood Pressure and Hypertension Studies
- Central Venous Catheters and Hemodialysis
- Hydrogen's biological and therapeutic effects
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Health and Disease Prevention
- Alcohol Consumption and Health Effects
- Pharmacological Effects and Toxicity Studies
- Sodium Intake and Health
- Protein Interaction Studies and Fluorescence Analysis
- Renal and Vascular Pathologies
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Case Reports on Hematomas
- Renal function and acid-base balance
- Sepsis Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Folate and B Vitamins Research
- Neurological and metabolic disorders
- Muscle metabolism and nutrition
- Heart Rate Variability and Autonomic Control
Teikyo University Chiba Medical Center
2017-2025
St. Luke's International Hospital
2024
St. Luke's International University
2024
Japanese Society for Dialysis Therapy
2020-2021
Fukushima Medical University
2012-2018
Fukushima Medical University Hospital
2014-2017
Shizuoka University
2014
Jikei University School of Medicine
2001-2012
Jikei University Kashiwa hospital
2008-2011
Tohoku University
2006-2010
Chronic Kidney Disease (CKD) has been shown to be a risk factor for mortality as well morbidity such cardiovascular disease (CVD) in the general population. However, context of CVD events, there is difference incidence cardiac and stroke events between Western Asian populations. Although high prevalence characteristic feature Japanese populations, it unclear whether CKD constitutes events.To clarify this issue, we estimated creatinine clearance obtained dipstick tests from spot-urine samples...
Abstract The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was sent to 4458 dialysis facilities at end 2018; among these facilities, 4402 (98.7%) responded facility questionnaire, and 4222 (94.7%) patient questionnaire. number chronic patients in Japan continues increase every year; as 2018, it had reached 339,841 patients, representing 2688 per million population. Among prevalent mean age 68.75 years, diabetic nephropathy most common primary disease...
Abstract Background The 2020 Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) annual survey was sent to 4493 dialysis facilities in Japan. Methods Questionnaires were all that provide patients with therapy collected and compiled form cross-sectional results of renal replacement from various aspects. Results In total, 4437 (98.8%) responded the facility questionnaire 4271 (95.1%) patient questionnaire. number chronic Japan continues increase every year, reaching 347,671 at end...
alpha-Oxoaldehydes such as glyoxal (GO), methylglyoxal (MG), and 3-deoxyglucosone (3DG) are precursors of advanced glycation end products exert direct toxicity to cells tissues. Plasma levels these substances reportedly elevated in diabetes dialysis patients, but the data on exact clinical significance chronic kidney disease (CKD) limited.We evaluated plasma alpha-oxoaldehyde using liquid chromatography mass spectrometry methods 19 healthy controls 99 CKD patients with or without (n = 46 n...
Abstract Background Hyperuricemia is prevalent in patients with chronic kidney disease (CKD). We explored the hypothesis that asymptmatic hyperuricemia may be associated new-onset CKD. Methods The participants were all male factory workers Kanagawa, Japan (n = 1,285). All over 40 years of age and had undergone annual health examinations from 1990 to 2007. Individuals a history gouty attacks excluded study. A retrospective cohort study was conducted by following estimated glomerular...
Abstract Human serum albumin is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing powers and oxidized non‐mercaptoalbumin. The aim this study to clarify whether such redox state (HSA‐redox) influences the incidence cardiovascular disease (CVD) in chronic kidney patients on regular hemodialysis (HD). We measured HSA‐redox using high‐performance liquid chromatography 86 anuric HD patients. association between incidental CVD events was evaluated. Twenty experienced...
The application of electrolyzed water (EW) at the cathode side to manufacture reverse osmosis (RO) and hemodialysis (HD) solution can actually lead less oxidative capacity in chemical terms. present study examined biological actions this on human polymorphonuclear leukocytes (PMNs), clinical feasibility applying technology HD treatment.RO using EW (e-RO) exhibited chemiluminescence luminol-hydrogen peroxide higher dissolved hydrogen levels (-99.0 ppb) compared with control RO water. effects...
Background: Shared decision-making (SDM) is a key process in selecting renal replacement therapy (RRT). This study analyzed SDM perceptions, preferences, and patient- facility-level factors influencing among Japanese patients with chronic kidney disease (CKD) who selected RRT. Methods: We 475 adult CKD from 49 medical facilities. awareness recognition, preferences for timing frequency, discussion content, desired professional involvement were assessed. Patient- associated perceptions...
<title>Abstract</title> <bold>Background</bold> Although an increase in plasma levels of non-esterified fatty acids (NEFA) during hemodialysis (HD) is reported, the precise pathophysiology remains unclear. We hypothesized that elevation NEFA reflects “cell starvation” or sudden-onset catabolism caused primarily by a steep depletion insulin HD session.<bold>Materials and Methods</bold> measured five cases circulating session under conditions without with intradialytic parenteral nutrition...
Chronic inflammation has recently been proposed to play a major role in the development of cardiovascular disease and mortality among advanced chronic kidney (CKD) patients; however, why CKD promotes is still unclear. We hypothesized that very low level plasma endotoxin (lipopolysaccharide [LPS]) contributes patients. measured LPS levels using novel detection method (ESP method, for laser scattering photometry) concurrently with serum C-reactive protein (CRP) various blood tests 17 stable...
Although peritoneal dialysis (PD) is recommended as the first-line treatment for end-stage renal disease, limitations exist to achieving good clinical status when residual function (RRF) has declined. Combined therapy with PD and hemodialysis (HD) of choice patients who cannot control body fluid and/or obtain adequate solute removal by alone. The aim this study was evaluate efficacy combined therapy.In retrospective study, 53 on diagnosed underdialysis overhydration declining RRF were...
<i>Background:</i> No previous study has investigated the association of kidney dysfunction with silent lacunar infarcts and white-matter hyperintensity (WMH) independent ambulatory blood pressure (BP). <i>Methods:</i> A cross-sectional involving 1,008 participants (mean age 66 years) from a general population Ohasama, Japan, was conducted. Calculated creatinine clearance (CCr) estimated using Cockcroft-Gault equation. In continuous categorical analyses, between CCr...
Tissue accumulation of advanced glycation end products (AGE) is thought to contribute the progression cardiovascular disease (CVD). Skin autofluorescence, a non-invasive measure AGE using autofluorescence skin under ultraviolet light, has been reported be an independent predictor mortality associated with CVD in Caucasian patients on chronic hemodialysis. The aim this study was assess predictive value all-cause and non-Caucasian (Japanese) Baseline measured reader 128 All-cause monitored...
High salt intake in patients with chronic kidney disease (CKD) may cause high blood pressure and increased albuminuria. Although, the estimation of is essential, there are no easy methods to estimate real intake.Salt was assessed by determining urinary sodium excretion from collected urine samples. Estimation spot calculated Tanaka's formula. The correlation between estimated measured evaluated Pearson´s coefficients. Performance equation median bias, interquartile range (IQR), proportion...
Abstract Elevated oxidative stress ( OS ) is associated with severe cardiovascular disease and premature death among patients treated hemodialysis HD ). Oxidative enhanced by contact between blood dialysis membranes during sessions. This study aimed to clarify whether hydrogen H 2 ), which a known antioxidant, capable of suppressing increased induced Eight on regular treatment were studied. Two sessions performed in cross‐over design trial using standard hydrogen‐enriched solutions (mean 50...