A5013782799- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Multiple and Secondary Primary Cancers
- Urologic and reproductive health conditions
- Frailty in Older Adults
- Esophageal Cancer Research and Treatment
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
- Pelvic floor disorders treatments
- Cancer Research and Treatments
- Renal and Vascular Pathologies
- Urinary Tract Infections Management
- Renal and related cancers
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Sexual function and dysfunction studies
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Organ Donation and Transplantation
- Cancer, Hypoxia, and Metabolism
Hirosaki University
2016-2025
University of Marketing and Distribution Sciences
2022-2024
Discovery Institute
2017-2021
Sanford Burnham Prebys Medical Discovery Institute
2017-2021
Osaka Ohtani University
2019-2020
Suzuki (Japan)
2020
Pharmac
2019
United States Department of Veterans Affairs
2018
Providence College
2018
Kōchi University
1992
Hyaluronan (HA) is an extremely large polysaccharide (glycosaminoglycan) involved in many cellular functions. HA catabolism thought to involve the initial cleavage of extracellular high-molecular-weight (HMW) into intermediate-size by or cell-surface hyaluronidase, internalization HA, and complete degradation monosaccharides lysosomes. Despite considerable research, identity hyaluronidase responsible for space remains elusive. HYAL1 HYAL2 have properties more consistent with lysosomal...
BackgroundNeoadjuvant chemotherapy (NAC) use for patients with locally advanced upper tract urothelial carcinoma (UTUC) is debatable.ObjectiveTo investigate the efficacy and safety of platinum-based NAC UTUC.Design, settings, participantsOf 233 consecutive who underwent radical nephroureterectomy, 55 received (NAC group) 138 did not (Ctrl group).Outcome measurements statistical analysisThe two arms vs NAC) were matched using propensity scores to minimize selection bias. We retrospectively...
ABSTRACT Objective We aimed to investigate the impact of skin adverse events (AEs) enfortumab vedotin (EV) on prognosis in patients with locally advanced or metastatic urothelial carcinoma real‐world practice. Methods This study analyzed data from 115 carcinoma. evaluated association between EV dose and AEs these patients. The progression‐free survival (PFS) overall (OS) was assessed using Kaplan–Meier curves Cox regression analysis. Results median PFS OS were 8.1 14.5 months, respectively....
ABSTRACT Background The α2,3‐sialyl N ‐glycosylated free prostate‐specific antigen ratio (S2,3PSA%) was approved in Japan as a prostate cancer (PCa) diagnostic test. We evaluated the analytical characterization and real‐world performance of S2,3PSA%. Methods precision testing, dilution linearity, measurement sensitivity, preanalytical stability, interferences S2,3PSA, α2,6‐sialyl PSA (S2,6PSA), S2,3PSA% were performed. accuracy detecting PCa prospectively 253 men (Cohort 1, vs. PI‐RADS) 145...
Core2 β-1,6-N-acetylglucosaminyltransferase (C2GnT) forms an N-acetylglucosamine branch in the O-glycans (core2 O-glycans) of cell surface glycoproteins. We previously revealed that expression C2GnT is positively correlated with poor prognosis prostate cancer patients. However, detailed mechanisms underlying their remain unclear. In current study, we report core2 carried by MUC1 glycoproteins cells play important role evasion NK immunity. C2GnT‑expressing cells, are modified...
The clinical impact of neoadjuvant chemotherapy (NAC) on oncological outcomes in patients with locally advanced upper tract urothelial carcinoma (UTUC) remains unclear. We investigated the platinum-based NAC for UTUC.Of 234 patients, 101 received (NAC group) and 133 did not (Control [Ctrl] group). regimens group included gemcitabine carboplatin (75%), cisplatin (21%). Pathological downstagings primary tumor lymphovascular invasion were significantly improved than Ctrl groups. UTUC prolonged...
The extracellular matrix (ECM) plays an important role in maintaining tissue homeostasis and poses a significant physical barrier to vivo cell migration. Accordingly, as means of enhancing invasion, tumor cells use metalloproteinases degrade ECM proteins. However, the is comprised not only proteins but also variety nonprotein components. Hyaluronan (HA), one most abundant components interstitial ECM, forms gel-like antiadhesive that impenetrable particulate matter cells. Mechanisms by which...
As a major component of the extracellular matrix, hyaluronan (HA) plays an important role in defining biochemical and biophysical properties tissues. In light extremely rapid turnover HA impact this on biology, elucidating molecular mechanisms underlying catabolism is key to understanding vivo functions unique polysaccharide. Here, we show that TMEM2, recently identified cell surface hyaluronidase, essential systemic turnover. Employing induced global Tmem2 knockout mice (Tmem2iKO),...
No AccessJournal of UrologyInvestigative Urology1 May 2011Requirement for FBP17 in Invadopodia Formation by Invasive Bladder Tumor Cells Hayato Yamamoto, Mihoko Sutoh, Shingo Hatakeyama, Yasuhiro Hashimoto, Takahiro Yoneyama, Takuya Koie, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Toshiya Nakamura, Chikara Ohyama, and Shigeru Tsuboi YamamotoHayato Yamamoto Department Urology, Graduate School Medicine, Hirosaki University, Hirosaki, Japan , SutohMihoko Sutoh Biochemistry, Oyokyo Kidney...
Objectives The aim of this study was to identify risk factors associated with postoperative delirium in patients undergoing urological surgery. Methods We prospectively evaluated pre- and for consecutive 215 who received surgery between August 2013 November 2014. Preoperative included patient demographics, comorbidities, frailty assessment. Frailty measured by handgrip strength, fatigue scale depression, fall assessment, gait speed (the timed Get-up Go test). Postoperative types anesthesia,...
Objectives To assess the effects of urinary diversion on renal function, we retrospectively investigated function over 5 years after using a propensity score matching strategy. Methods Between May 1996 and November 2013, 345 consecutive adult patients underwent radical cystectomy in our hospital; one hundred fifteen with more than 5-year follow-up were enrolled. Propensity scores calculated logistic analysis, data used analyses included age, gender, Eastern Cooperative Oncology Group...
Abstract Objectives To evaluate the relationship between frailty and lower urinary tract symptoms (LUTS), association of LUTS remains unclear. Methods This cross‐sectional study investigated in 710 individuals (249 men 461 women, aged ≥60 years) who participated Iwaki Health Promotion Project 2014 2015 Hirosaki, Japan. Parameters were compared for with mild moderate to severe LUTS. The International Prostate Symptom Score (IPSS) Overactive Bladder (OABSS) used Frailty was evaluated by...
Objectives To evaluate the association between score of Geriatric 8 screening tool and treatment by disease stages in patients with prostate cancer. Methods Between January 2017 June 2019, we prospectively evaluated 540 cancer who were treated robot‐assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone standard care for metastatic hormone‐naïve or castration‐resistant The primary purpose was frailty (Geriatric ≤14) alone, diseases. Secondary purposes included a...
The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated effect its in with chronic kidney disease. present retrospective pair-matched study included 560 patients, grouped according whether or not they received before (AST-120 non-AST-120 groups). cumulative free rate were compared by Kaplan-Meier method. Multivariate analysis was used determine impact initiation. Our results showed significant differences 12-...
// Itsuto Hamano 1 , Shingo Hatakeyama Hiromichi Iwamura Naoki Fujita Ken Fukushi Takuma Narita Kazuhisa Hagiwara Ayumu Kusaka Shogo Hosogoe Hayato Yamamoto Yuki Tobisawa Tohru Yoneyama 2 Takahiro Yasuhiro Hashimoto Takuya Koie Hiroyuki Ito 3 Kazuaki Yoshikawa 4 Toshiaki Kawaguchi 5 and Chikara Ohyama 1, Department of Urology, Hirosaki University Graduate School Medicine, Hirosaki, Japan Advanced Transplant Regenerative Aomori Rosai Hospital, Hachinohe, Mutsu General Mutsu, Prefectural...
The incidence of secondary neoplasms the testis during autopsies is approximately 2.5%. Although most testicular metastases are due to prostate cancer, only a few patients with cancer have clinically manifested metastasis. We report case patient metastasis who was diagnosed after presence palpable mass in right testis. A 56-year-old Japanese male presented our hospital an elevated serum prostate-specific antigen (PSA) level 137 ng/ml. He stage IV (T3N1M1b) and received androgen deprivation...
Abstract We investigated the diagnostic and prognostic potential of serum N -glycan profiling for castration-resistant prostate cancer (CRPC). retrospectively structural analysis by glycoblotting 287 patients with benign prostatic hyperplasia (BPH), 289 newly diagnosed (PC), 57 PC treated androgen-deprivation therapy without disease progression (PC-ADT), 60 CRPC. -Glycan was compared between non-CRPC (BPH, PC-ADT) CRPC patients. obtained quantitative score (CRPC score) discriminant based on...