A5044499778- Bladder and Urothelial Cancer Treatments
- Chronic Kidney Disease and Diabetes
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Diabetes Treatment and Management
- Urologic and reproductive health conditions
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Urological Disorders and Treatments
- Dialysis and Renal Disease Management
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- Urinary Bladder and Prostate Research
- Renal and Vascular Pathologies
- Multiple Myeloma Research and Treatments
- Pharmacology and Obesity Treatment
- Cancer Research and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Advanced Glycation End Products research
- Frailty in Older Adults
Hirosaki University
2013-2023
Akita University
2010-2023
Discovery Institute
2023
Sanford Burnham Prebys Medical Discovery Institute
2023
Akita Industrial Technology Center
2023
University of Tsukuba
2022
Hirosaki National Hospital
2020-2021
Nagoya City University
2012-2019
Nagasaki University
2013
Akita University Hospital
1999-2002
Abstract Aims/Introduction To investigate the prevalence of sarcopenia, its related factors and indicators physical evaluation in elderly diabetes patients. Materials Methods This was a cross‐sectional observation study. A total 267 patients (159 men, 108 women) aged >65 years were recruited present Skeletal muscle mass index, grip strength usual gait speed measured to diagnose sarcopenia according Asian Working Group for Sarcopenia. Body composition using bioelectrical impedance...
The IRE1α-XBP1 pathway, a key component of the endoplasmic reticulum (ER) stress response, is considered to be critical regulator for survival multiple myeloma (MM) cells. Therefore, availability small-molecule inhibitors targeting this pathway would offer new chemotherapeutic strategy MM. Here, we screened ER stress-induced XBP1 activation, and identified toyocamycin from culture broth an Actinomycete strain. Toyocamycin was shown suppress thapsigargin-, tunicamycin- 2-deoxyglucose-induced...
Dipeptidyl peptidase-4 (DPP-4) inhibitor is a new class of anti-diabetic drug which exerts its glucose-lowering action by suppressing the degradation gut incretin hormone glucagon-like peptide-1 (GLP-1). To elucidate whether treatment with stronger DPP-4 on top angiotensin II type 1 receptor blocker (ARB) provides greater renal protective effects, we performed crossover study two inhibitors, sitagliptin and alogliptin, in twelve 2 diabetic patients incipient nephropathy taking ARBs. This...
OBJECTIVE—Increased urinary excretions of several plasma proteins with different molecular radii <55 Å and isoelectric points (pI), such as IgG, ceruloplasmin, transferrin, orosomucoid, have been independently reported to precede the development microalbuminuria in diabetic patients. We examined whether increases these would be parallel same patient. RESEARCH DESIGN AND METHODS—Urinary excretion rates mentioned above timed overnight urine samples were evaluated 61 normoalbuminuric...
To compare the effects of miglitol [an alpha‐glucosidase inhibitor (AGI) absorbed in intestine] and voglibose (an AGI not absorbed) on plasma glucagon‐like peptide‐1 (GLP‐1) gastric inhibitory polypeptide (GIP) levels, 26 24 Japanese type 2 diabetic patients were randomly assigned to receive or voglibose, respectively. After 12‐week administration both drugs, during 2‐h meal tolerance test, glucose, serum insulin total GIP significantly decreased active GLP‐1 was increased. Miglitol group...
Microalbuminuria is generally considered as the best available noninvasive predictor of diabetic nephropathy. However, several studies have shown that increases in certain urinary proteins (immunoglobin G [IgG] [1–3], transferrin [Tf] [4–7], and ceruloplasmin [CRL] [3,8]) were found normoalbuminuric patients. Recently, we reported patients, there was a strong linear correlation among these (9). To assess whether increased excretions IgG, CRL, Tf can predict development microalbuminuria,...
Abstract Background Management of renal cell carcinoma (RCC) with tumor thrombus extending to the vein and inferior vena cava (IVC) is challenging. The aim this study was evaluate benefit surgical management in such patients. Methods From February 1995 2013, 520 patients were treated for RCC at Hirosaki University Hospital, Hirosaki, Japan. (n = 42) IVC 43) included study. records these 85 retrospectively reviewed assess relevant clinical pathological variables survival. Prognostic factors...
Abstract Bortezomib (BTZ), a proteasome inhibitor, is widely used in the treatment of multiple myeloma (MM), but fraction patients respond poorly to this agent. To identify factors predicting duration progression-free survival (PFS) MM on BTZ treatment, expression and endoplasmic reticulum (ER) stress-related genes was quantified primary samples from receiving combination dexamethasone (BD). Fifty-six were stratified into group with PFS<6 months ( n =33) second PFS⩾6 =23). Of 15 analyzed,...
Objectives To assess the effects of urinary diversion on renal function, we retrospectively investigated function over 5 years after using a propensity score matching strategy. Methods Between May 1996 and November 2013, 345 consecutive adult patients underwent radical cystectomy in our hospital; one hundred fifteen with more than 5-year follow-up were enrolled. Propensity scores calculated logistic analysis, data used analyses included age, gender, Eastern Cooperative Oncology Group...
Adiponectin is an adipose-derived protein which has anti-inflammatory and anti-atherogenic properties in addition to insulin-sensitizing effects. To date, the role of adiponectin pathogenesis diabetic nephropathy remains unclear. The aim present study was explore relationship between renal tubular injury nephropathy. We determined serum urinary levels type 2 patients with normoalbuminuria (n = 19), microalbuminuria 18), overt 16), then analyzed correlations adiponectin,...
Decreased circulating levels of adiponectin, a novel adipose-derived adipocytokine, in obesity possibly contribute to the development insulin resistance which is major factor pathogenesis type 2 diabetes. The present study was conducted examine whether and adipose tissue adiponectin are modulated by chronic treatment with metformin intensive murine models diabetes, db/db mice C57BL/KsJ genetic background. Nine-week-old male were treated metformin, insulin, vehicle for 4 weeks. Expectedly,...
Renal superoxide excess, which is induced by an imbalance of the superoxide-producing enzyme NAD(P)H oxidase and superoxide-scavenging dismutase (SOD) under hyperglycemia, increases oxidative stress contributes to development diabetic nephropathy. In this study, we treated non-obese hypoinsulinemic C57BL/6-Ins2(Akita) (C57BL/6-Akita) mice with telmisartan (5 mg kg(-1) per day), angiotensin II type 1 receptor blocker, or amlodipine a calcium channel for 4 weeks compared effects these two...
// Itsuto Hamano 1 , Shingo Hatakeyama Hiromichi Iwamura Naoki Fujita Ken Fukushi Takuma Narita Kazuhisa Hagiwara Ayumu Kusaka Shogo Hosogoe Hayato Yamamoto Yuki Tobisawa Tohru Yoneyama 2 Takahiro Yasuhiro Hashimoto Takuya Koie Hiroyuki Ito 3 Kazuaki Yoshikawa 4 Toshiaki Kawaguchi 5 and Chikara Ohyama 1, Department of Urology, Hirosaki University Graduate School Medicine, Hirosaki, Japan Advanced Transplant Regenerative Aomori Rosai Hospital, Hachinohe, Mutsu General Mutsu, Prefectural...
Transmembrane protein 2 (TMEM2) was originally identified as a membrane-anchored of unknown function. We previously demonstrated that TMEM2 can degrade hyaluronan (HA). Furthermore, we showed induced global knockout Tmem2 in adult mice results rapid accumulation incompletely degraded HA bodily fluids and organs, supporting the identity cell surface hyaluronidase. In spite these advances, no direct evidence has been presented to demonstrate intrinsic hyaluronidase activity TMEM2. Here,...
The aim of this study was to examine the relationship between degree urinary copper excretion and stages diabetic nephropathy.Copper, ceruloplasmin albumin concentrations were measured in serum urine samples from 41 type 2 outpatients with different nephropathy 10 healthy controls. copper/albumin copper/ceruloplasmin ratios determined. Furthermore, we examined whether free ions are dissociated under various pH conditions.Urinary significantly increased only macroalbuminuric patients....