A5101450160- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Radiopharmaceutical Chemistry and Applications
- Algal biology and biofuel production
- Structural Health Monitoring Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Herpesvirus Infections and Treatments
- Cancer therapeutics and mechanisms
- Urinary and Genital Oncology Studies
- Mechanical Behavior of Composites
- Colorectal and Anal Carcinomas
- Advanced materials and composites
- Intermetallics and Advanced Alloy Properties
- Fatty Acid Research and Health
- Pancreatic and Hepatic Oncology Research
- Structural Response to Dynamic Loads
- Microbial Metabolic Engineering and Bioproduction
- Ultrasonics and Acoustic Wave Propagation
- Ovarian cancer diagnosis and treatment
Hirosaki University
2005-2025
Japanese Red Cross Hadano Hospital
2020-2024
Red Cross Hospital
2024
National Cancer Center Hospital East
2018-2023
Iwate Medical University
1996-2020
Tokyo National Hospital
2017-2020
National Cancer Center
2019
Shinshu University
2009-2017
Tokyo Metropolitan University
2016
Yokohama Minami Kyosai Hospital
2015
ABSTRACT Background The α2,3‐sialyl N ‐glycosylated free prostate‐specific antigen ratio (S2,3PSA%) was approved in Japan as a prostate cancer (PCa) diagnostic test. We evaluated the analytical characterization and real‐world performance of S2,3PSA%. Methods precision testing, dilution linearity, measurement sensitivity, preanalytical stability, interferences S2,3PSA, α2,6‐sialyl PSA (S2,6PSA), S2,3PSA% were performed. accuracy detecting PCa prospectively 253 men (Cohort 1, vs. PI‐RADS) 145...
Predictive biomarkers of the response hepatocellular carcinoma (HCC) to Lenvatinib therapy have not yet been clarified. The aim this study was identify clinically significant therapy, target strategies against HCC. Levels circulating angiogenic factors (CAFs) were analyzed in blood samples collected at baseline and after introducing lenvatinib, from 74 Child-Pugh class A HCC patients who received lenvatinib. As CAF biomarkers, serum vascular endothelial growth factor (VEGF), fibroblast 19...
To assess the impact of clinical factors on safety and efficacy atezolizumab plus bevacizumab (ATZ + BV) treatment in patients with unresectable hepatocellular carcinoma (u-HCC).Ninety-four u-HCC who were treated ATZ BV at multiple centers enrolled. We defined Child-Pugh (CP)-A received as a first line therapy 'meets broad sense IMbrave150 criteria' group (B-IMbrave150-in, n = 46), later or CP-B (regardless whether was therapy) B-IMbrave150-out (n 48). Patients retrospectively analyzed for...
ABSTRACT Objective Prostate‐specific antigen (PSA)‐based screening has reduced prostate cancer (PCa) mortality but is associated with overdiagnosis/overtreatment. We developed and evaluated a blood‐based S2,3PSA% test to address the limitations of PSA‐based for PCa. Methods This retrospective study included men aged ≤ 75 years who underwent opportunistic PSA between April 2022 March 2023. Secondary was recommended participants ≥ 2.0 ng/mL 38.0%, or 4.0 ng/mL. The primary outcome reduction in...
ABSTRACT Objective Programmed cell death ligand 1 (PD‐L1) expression is considered a poor prognostic factor in patients with muscle‐invasive bladder cancer (MIBC). However, the data regarding change PD‐L1 before and after neoadjuvant chemotherapy (NAC) are limited. We aimed to investigate longitudinal association between programmed death‐ligand Ki‐67 NAC Methods retrospectively analyzed 191 MIBC who underwent platinum‐based followed by radical cystectomy (RC) June 2010 March 2022. excluded...
Sandwich-structure materials consist of a high-strength skin material and lightweight core material. The advantages sandwich structures are known to include excellent mechanical properties low weight. Sandwich because their core; meanwhile, the structure provides strength bears bending stress. Carbon-fiber-reinforced plastic (CFRP) is high-specific-strength high-specific-rigidity In recent years, CFRP have been used in aerospace applications due properties. However, soft-core members such as...
To evaluate the effects of concomitant use proton pump inhibitors (PPIs) and/or antibiotics (Abs) on oncological outcomes in patients with advanced urothelial carcinoma.We retrospectively evaluated 155 carcinoma who were treated immune checkpoint (ICIs) between August 2015 and April 2021. The PPI or Abs was defined as any administered within 30 days before ICI initiation during therapy. primary effect objective response rate (ORR) immune-related adverse events (irAEs). secondary...
Double gynecologic cancer (primary cancers in two organs) is relatively rare. However, triple three extremely We experienced a case of cancer, with primary cervical, endometrial and ovarian cancers, each showing different histopathological features. A 50-year-old woman preoperative diagnosis cervical stage Ib1 pathological mucinous adenocarcinoma underwent radical hysterectomy. The diagnoses the extracted masses were endometrioid uterine corpus serous left ovary. Consequently, was diagnosed....
We measure the dose distribution of gated delivery for different target motions and estimate gating latency in a magnetic resonance-guided radiotherapy (MRgRT) system.The accuracy MRgRT system (MRIdian, Viewray) was investigated using an in-house-developed phantom that compatible with field method. This contains simulated tumor radiochromic film (EBT3, Ashland, Inc.). To investigate effect number beam switching velocity on distribution, two types were applied. One is periodically moved at...
Screening of fatty acid composition in 150 strains marine microalgae, cyanobacteria and green algae was carried out, 20 showed relatively high contents palmitoleic acid. Among them, two cyanobacteria, Phormidium sp. NKBG 041105 Oscillatoria 091600, an unusually cis-palmitoleic content (54.5% 54.4% total acid, respectively). had the highest per biomass (46.3 mg (g dry cell weight)−1), cis-palrnitoleic found to be constant with varying temperature. These results indicate that this...
γ-Linolenic acid (GLA) production using a high GLA producing marine green alga, Chlorella sp. NKG 042401, was studied. presented in the galactolipid fraction (37.9%/total fatty acids). The effects of growth conditions on were Optimum salinity for 5 g 1−1, at which highest cell concentration achieved, resulting 1.6-fold increase productivity. Total acid, however, not drastically affected by change salinity. Nitrogen starvation decreased ratio unsaturated acids, and consequently total...
To evaluate the effect of postoperative pathological findings related to eligibility adjuvant immunotherapy on oncologic outcomes in patients with localized and locally advanced muscle-invasive bladder carcinoma (MIBC) upper tract urothelial (UTUC).We retrospectively evaluated 1082 treated radical cystectomy (n = 597) nephroureterectomy 485) between January 2000 April 2021. Patients were divided into two groups: pT3-4 or pN+ without neoadjuvant chemotherapy ypT2-4 (trial-eligible group)...
Our purpose was to establish the commissioning procedure of Monte Carlo modeling on a magnetic resonance imaging-guided radiotherapy system (MRIdian, Viewray Inc.) under field 0.345 T through experimental measurements. To do this, we sought (i) assess depth-dose and lateral profiles generated by Geant4 using either EBT3 film or BJR-25 data; (ii) calculation accuracy T. The radius electron trajectory caused return effect (ERE) in vacuum obtained both theoretical methods. surface dose phantom...
Patients with end-stage cancer have poorly controlled ascites retention resulting due to cancerous peritonitis. We intraperitoneally administered triamcinolone acetonide (TA) patients gynecological as a pilot study, and our treatment results are reported herein.We enrolled 26 requiring frequent abdominal paracentesis for drainage between April 2010 September 2012. The volume of was 2000 3000 mL per session, TA at 10 mg/kg after drainage. compared intervals, performance status (PS), total...
Boron Neutron Capture Therapy (BNCT) has recently been used in clinical oncology thanks to recent developments of accelerator-based BNCT systems. Although there are some specific processes for BNCT, they have not yet discussed detail.The aim this study is provide comprehensive data on the risk system institutions planning implement an system.In study, failure mode and effects analysis (FMEA) was performed based a treatment process map prepared system. A multidisciplinary team consisting...
Recently, high-density printed circuit boards (HD-PCBs) with less than 50 mum/50 mum line/space has been developed. In the HD-PCB, since spacing between adjacent signal lines becomes very small, crosstalk electromagnetic interference among serious. general, in order to suppress crosstalk, ground line is located at because of decrease mutual capacitance lines. The authors have proposed a magnetic method for reducing crosstalk. composite material was filled instead line. composed Fe-Si-B-Cr...