A5033901349- Attention Deficit Hyperactivity Disorder
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Renal and related cancers
- Gene expression and cancer classification
- Bipolar Disorder and Treatment
- Autism Spectrum Disorder Research
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Protein Degradation and Inhibitors
- Analytical Methods in Pharmaceuticals
- Computational Fluid Dynamics and Aerodynamics
- Infant Development and Preterm Care
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory mediators and NSAID effects
- Children's Physical and Motor Development
- Identity, Memory, and Therapy
- Multiple Myeloma Research and Treatments
- Genomics and Chromatin Dynamics
- Advanced Numerical Methods in Computational Mathematics
- Gene Regulatory Network Analysis
- Numerical methods for differential equations
Oregon Health & Science University
2013-2025
Oregon Research Institute
2020
Oregon Clinic
2020
University of California, Santa Cruz
2017
Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic options. We previously combined ex vivo drug sensitivity genomic, transcriptomic, and clinical annotations for large cohort AML patients, which facilitated discovery functional genomic correlates. Here, we present dataset that has been harmonized our initial report to yield cumulative 805 patients (942 specimens). show strong cross-cohort concordance identify features response. Further, deconvoluting...
A central nosological problem concerns the etiological relationship of emotional dysregulation with ADHD. Molecular genetic risk scores provide a novel method for informing this question.Participants were 514 community-recruited children Northern European descent age 7-11 defined as ADHD or non-ADHD by detailed research evaluation. Parents-rated on standardized ratings and child temperament Temperament in Middle Childhood Questionnaire (TMCQ) reported comorbid disorders semi-structured...
Abstract Epigenetic variation in peripheral tissues is being widely studied as a molecular biomarker of complex disease and disease-related exposures. To date, few studies have examined differences DNA methylation associated with attention-deficit hyperactivity disorder (ADHD). In this study, we profiled genetic methylomic across the genome saliva samples from children (age 7–12 years) clinically established ADHD ( N = 391) nonpsychiatric controls 213). We tested for differentially...
attention-deficit/hyperactivity disorder (ADHD) is associated with both polygenic liability and environmental exposures, intrinsic to the family, such as family conflict, extrinsic, air pollution. However, much less known about interplay between genetic risks relevant ADHD-a better understanding of which could inform mechanistic models clinical prediction algorithms.
The fields of developmental psychopathology, neuroscience, and behavioral genetics are increasingly moving toward a data sharing model to improve reproducibility, robustness, generalizability findings. This approach is particularly critical for understanding attention-deficit/hyperactivity disorder (ADHD), which has unique public health importance given its early onset, high prevalence, individual variability, causal association with co-occurring later developing problems. A further priority...
Abstract Background Mechanistic endophenotypes can inform process models of psychopathology and aid interpretation genetic risk factors. Smaller total brain subcortical volumes are associated with attention-deficit hyperactivity disorder (ADHD) provide clues to its development. This study evaluates whether common for ADHD is volume (TBV) hypothesized structures in children. Methods Children 7–15 years old were recruited a case–control ( N = 312, 199 ADHD). assessed multi-informant,...
We introduce a novel method called Prophetic Granger Causality (PGC) for inferring gene regulatory networks (GRNs) from protein-level time series data. The uses an L1-penalized regression adaptation of to model protein levels as function time, stimuli, and other perturbations. When combined with data-independent network prior, the framework outperformed all methods submitted HPN-DREAM 8 breast cancer inference challenge. Our investigations reveal that PGC provides complementary information...
Patient-specific aberrant expression patterns in conjunction with functional screening assays can guide elucidation of the cancer genome architecture and identification therapeutic targets. Since most statistical methods for analysis are focused on differences between experimental groups, performance approaches patient-specific analyses currently less well characterized. A comparison genes that dysregulated relative to a single sample given set samples, our knowledge, has not been performed....
Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic options. We previously combined ex vivo drug sensitivity genomic, transcriptomic, and clinical annotations for large cohort AML patients, which facilitated discovery functional genomic correlates. Here, we present new dataset, has been harmonized our initial report to yield cumulative 805 patients (942 specimens). show strong cross-cohort validation identify features response. Further, deconvoluting...
Abstract Monosomy 7 is among the most frequent cytogenetic abnormalities in hematological disorders and associated with short survival drug resistance. Despite its high prevalence detrimental impact, therapeutic vulnerabilities underlying monosomy 7-associated blood remain largely elusive, impeding progress toward improved patient care. The homeostatic cellular requirement for a normal dosage of essential genes creates an opportunity to target that arise due reduced levels proteins encoded...
Summary Upregulation of the Wilms' tumour 1 ( WT1 ) gene is common in acute myeloid leukaemia (AML) and associated with poor prognosis. generates 12 primary transcripts through different translation initiation sites alternative splicing. The short express abundantly samples. We observed that overexpression lacking exon 5 without KTS motif sWT1 +/− −/−) led to reduced cell growth. However, only sWT1+/− resulted decreased CD71 expression, G1 arrest, cytarabine resistance. Primary AML patient...
Abstract Epigenetic processes, such as DNA methylation, show potential biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences brain itself. An increasingly popular approach address this by combining neuroimaging data; yet, research area almost entirely comprised cross-sectional studies adults. To bridge gap, we...
Introduction. Estimates of prevalence and comorbidity ADHD in the United States require additional national, multi-informant data. Further, it is unclear whether polygenic, neurodevelopmental model DSM-5 best modeled with a broad or restrictive phenotype definition. Method: In Adolescent Behavior Cognition Development (ABCD) study baseline data on 9-10 year old children, prevalence, comorbidity, association cognitive functioning polygenic risk were calculated at four thresholds definition...
ABSTRACT Deficits in effective executive function, including inhibitory control are associated with risk for a number of psychiatric disorders and significantly impact everyday functioning. These complex traits have been proposed to serve as endophenotypes, however their genetic architecture is not yet well understood. To identify the common variation general population we performed first trans-ancestry genome wide association study (GWAS) combining data across 8 sites four ancestries...
Abstract Upregulation of the Wilms' Tumor 1 (WT1) gene is common in acute myeloid leukemia and associated with poor prognosis. WT1 produces 12 primary transcripts through different translation initiation sites alternative splicing. We found that overexpression short lacking exon 5 without KTS motif (sWT1+/- sWT1-/-) led to reduced cell growth. However, only sWT1+/- resulted decreased CD71 expression, G1 arrest, cytarabine resistance. Primary AML patient cells low expression exhibit relative...