A5042552384- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Radiation Therapy and Dosimetry
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Telomeres, Telomerase, and Senescence
- Hepatocellular Carcinoma Treatment and Prognosis
- FOXO transcription factor regulation
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Peking Union Medical College Hospital
2022
<h2>Abstract</h2> As sorafenib is a first-line drug for treating advanced hepatocellular carcinoma, resistance has historically attracted attention. However, most of this attention been focused on series mechanisms related to arising after treatment. In study, we used proteomic techniques explore the potential by which pretreatment factors affect resistance. The degree redundant pathway PI3K/AKT activation, biotransformation capacity, and autophagy level in carcinoma patients prior treatment...
As a critical early event in hepatocellular carcinogenesis, telomerase activation might be promising and biomarker for carcinoma (HCC) patients, its function the genesis treatment of HCC has gained much attention over past two decades.
Purpose. Studying the pathogenesis of liver cancer is conducive to exploration effective diagnostic and prognostic biomarkers. In this study, we investigated expression FOXA1 its oncogenic role in hepatocellular carcinoma (HCC). Methods. Transcriptome data HCC tissues were downloaded from The Cancer Genome Atlas (TCGA) GEO databases analyzed using R software. We also upregulated cells proliferation migration through proliferation, colony formation, wound healing, Transwell assays. Results....
Embryonic development and tumorigenesis have a certain degree of similarity. Alpha-fetoprotein (AFP), protein related to embryonic development, is well-known biomarker for the diagnosis prognosis hepatocellular carcinoma (HCC). In this study, we analyzed differences in gene expression profiles molecular mechanisms human HCC tissues from patients AFPhigh (serum AFP level ≥ 25 ng/mL) AFPlow < groups. The results indicated that has more malignant biological characteristics. Single-sample set...
Abstract Background and Aims Recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), especially those infected with HBV. Telomerase reverse transcriptase (TERT) promoter most prevalent site HBV-related HCC. We attempted to evaluate prognostic value TERT mutation status HCC patients. Methods enrolled 66 patients who underwent hepatectomy between January 2013 May 2016. DNA extracted from fresh tumor tissues these was subjected Sanger sequencing optimized droplet...