A5100400769- Pharmacological Effects of Natural Compounds
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Natural product bioactivities and synthesis
- Lipid metabolism and disorders
- Microbial Metabolism and Applications
- Bioactive natural compounds
- Advanced Drug Delivery Systems
- Medicinal Plant Pharmacodynamics Research
- Biochemical Analysis and Sensing Techniques
- Pharmaceutical studies and practices
- Cytokine Signaling Pathways and Interactions
- Mangiferin and Mango Extracts
- Pharmacogenetics and Drug Metabolism
- Berberine and alkaloids research
- Phenothiazines and Benzothiazines Synthesis and Activities
- PARP inhibition in cancer therapy
- Safe Handling of Antineoplastic Drugs
- Glycosylation and Glycoproteins Research
- Uterine Myomas and Treatments
- Ginger and Zingiberaceae research
- Biological and pharmacological studies of plants
- Computational Drug Discovery Methods
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
Jilin Agricultural Science and Technology University
2025
Shaanxi University of Chinese Medicine
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Guang’anmen Hospital
2023
China Academy of Chinese Medical Sciences
2023
Chengdu University of Traditional Chinese Medicine
2023
Henan University of Science and Technology
2022
Fudan University
2022
Shandong University of Traditional Chinese Medicine
2022
Hainan Medical University
2021
Abstract Background The frequently occurred chemotherapy-induced diarrhea (CID) caused by irinotecan (CPT-11) administration has been the most representative side-effects of CPT-11, resulting in chemotherapy suspension or failure. Our previous studies indicated that Gegen Qinlian formula exhibited a significant alleviation effect on CPT-11-induced diarrhea. However, referencing to Japanese Kampo medicine, TCM standard decoction would supply gap between ancient preparation application and...
Aim: The dual-ligand glycyrrhetinic acid and galactose-modified chitosan nanoparticles were designed to further improve the targeting capability hepatocellular carcinoma (HCC). Materials & methods: fabricated by using ionic gelation method their characteristics have been measured. Furthermore, biodistribution biocompatibility of this vehicle investigated in vitro vivo, respectively. Results: was specifically internalized into hepatoma cells accumulated tumor tissue vivo with high efficacy....
Linn (Leguminosae) is often used in Yi ethnic medicine to treat pain, fracture, and rheumatism.
Objective . To systematically evaluate the effectiveness of Shenqi Jiangtang granule (SQJT) in treatment type 2 diabetes. Methods We searched CNKI, Wanfang Data, VIP, and PubMed databases to collect randomized controlled trials (RCT) granules The search time was from January 2014 present. Data were extracted, quality evaluated. Metadata analysis extracted data carried out using RevMa5.2 software. final results are expressed relative risk (RR), mean difference (MD), 95% CI. Results This study...
To observe the mechanism of prepared Radix Rehmanniainon combined with Astragali in treating osteoporosis.Osteoporosis rat model was established by bilateral ovariectomy low-calcium diet feeding. Bone mineral density measured bone densitometer. metabolism markers serum were detected enzyme linked immunosorbent assay (ELISA), tissue structure observed hematoxylin-eosin staining, and effect on PI3K-AKT signaling pathway investigated immunohistochemistry reverse transcription polymerase chain...
Ethnopharmacological relevance: Yiqi Tongluo formula (YQTLF) is a commonly used clinical prescription of Academician Tong Xiaolin, which has significant therapeutic effect on diabetic microvascular complications. Our previous studies indicated that YQTLF could effectively prevent and delay the progression retinopathy, but its mechanism prevention treatment DN still unclear.Aim Study: was demonstrated efficacy safety in DN, however potential remains unclear. The aim this study to investigate...
The co-amorphous solid dispersion (c-ASD) is a useful method to enhance the water solubility of poorly soluble drugs. objective this study was improve dissolution Neohesperidin (NE) by binary c-ASD, which has not yet been applied NE. Since NE and Naringin (NA) co-exist abundantly in Chinese herbal medicine, Fructus Aurantii Immaturus, it hypothesised that NA served as co-former NE-NA c-ASD profile selected prepare with weight ratio 4:10, 10:10, 10:4 lyophilisation. They were characterized...
The aim of this study is to investigate whether escin ameliorates brain injury by improving intestinal dysfunction in middle cerebral artery occlusion (MCAO) rats. MCAO rats and lipopolysaccharides (LPS)-induced Caco-2 cells were used evaluate the effects vivo vitro. Escin abated not only decreases Garcia test scores but also increases infarct volume, levels corticosterone (Cort), endotoxin, IL-1β, TNF-α, diamine oxidase Further results showed that did cross blood barrier. Intestinal...
Elucidating the therapeutical basis and functional mechanism of traditional Chinese medicine (TCM) is still a challenge faced by researchers since effects TCM are always achieved interactions multiple components targets.