A5049435131- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Parasitic infections in humans and animals
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- Hemophilia Treatment and Research
- Autoimmune Bullous Skin Diseases
- Congenital Anomalies and Fetal Surgery
- Pleural and Pulmonary Diseases
- Multiple and Secondary Primary Cancers
- Histone Deacetylase Inhibitors Research
- Animal Ecology and Behavior Studies
- Spinal Dysraphism and Malformations
- Chemotherapy-related skin toxicity
- Neutropenia and Cancer Infections
- Glutathione Transferases and Polymorphisms
- Pneumothorax, Barotrauma, Emphysema
- Malaria Research and Control
Hopital Universitaire Hedi Chaker
2009-2025
University of Sfax
2017-2024
Palmetto Hematology Oncology
2019-2022
Franche-Comté Électronique Mécanique Thermique et Optique - Sciences et Technologies
2017
Acquired hemophilia A is an uncommon disease often presented with bleeding episodes causing a significant mortality risk. The main responsible for the threatening hemorrhagic disorder Factor VIII autoantibody's development. inhibitors' presence frequently idiopathic, but it can be associated malignancy, pregnancy, drugs and autoimmune diseases. In this report, we present first case of acquired primary biliary cholangitis. 48-year-old man, diffuse oral after tooth extraction. Hemostasis...
Gilbert’s Syndrome (GS) is a hereditary disease that can cause hyperbilirubinemia due to mutation in the promoter of UGT1A1 gene, which causes decrease uridine diphosphate glucuronyltransferase enzyme activity. Polymorphisms gene are associated with induced by Tyrosine Kinase Inhibitors (TKI) Chronic Myeloid Leukemia (CML). We report case patient who developed hepatotoxicity when treated on Imatinib and subsequently diagnosed syndrome. Eight months after initiating Imatinib, conjunctival...
The P-glycoprotein (P-gp) is one of the mechanisms Imatinib (IM) resistance in chronic myeloid leukemia (CML). P-gp has been identified as an efflux pump involved releasing IM outside CML cells. To date, involvement development was not completely understood. Therefore, present study aimed at measuring expression level on lymphocytes from Tunisian patients with and correlating this a molecular response to IM.The peripheral blood 59 (27 responder vs 32 non-responder patients) evaluated by flow...
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms, mainly the C677T, have been implicated as risk factors for several cancers acute lymphoblastic leukemia (ALL). In addition, a potential effect of such variant on efficacy methotrexate (MTX) has reported.In this study, we evaluated impact C677T MTHFR MTX-related toxicity in ALL patients from Tunisia; to provide new insights personalized therapy based human genotype.Genotyping was carried out with restriction fragment length...
Introduction Imatinib is a first-line selective tyrosine kinase inhibitor used for the treatment of chronic myeloid leukemia. Although imatinib-induced hepatotoxicity may aggravate patient's clinical condition and alter plan, mechanism has rarely been investigated. Case report We 51-year-old man, suffering from acute toxic hepatitis after 5 months imatinib Management outcome The was favorable discontinuation with normalization biological liver function 12 weeks. switched to nilotinib without...
Abstract Objective Our study aimed to investigate the association between cytochrome P450 1A1 ( CYP1A1 ) polymorphisms (T3801C and A2455G) acute lymphoblastic leukemia (ALL) risk, considering genetic models ethnicity. Materials methods PubMed, Embase, Web of Knowledge, Scopus, Cochrane electronic databases were searched using combinations keywords related risk ALL. Studies retrieved from database searches underwent screening based on strict inclusion exclusion criteria. Results In total,...
Pancreatic myeloid sarcoma is a rare manifestation of neoplasms.Its diagnosis can be challenging due to its rarity and potential mimic other pancreatic malignancies.We report case revealing acute leukemia.
Background: Relapsed acute lymphoblastic leukemia (ALL) has remained challenging to treat in children, with survival rates lagging well behind those observed at initial diagnosis. Although there have been some improvements outcomes over the past few decades, only ∼50% of children first relapse ALL survive long term, and are much worse second or later relapses. Aims: In this study we describe clinical characteristics therapeutics results childhood ALL. Methods: Our included under 16 years on...
Mucormycosis because of Lichtheimia ramosa is an unusual opportunistic fungal infection that can potentially be fatal in immunocompromised hosts. We present a case mucormycosis, affecting 59-year-old woman with diabetes and acute myeloid leukemia. Palatal mucormycosis sinonasal invasion was confirmed by mycological culture histopathology. Exact species identification performed PCR-sequencing ITS1-5.8S- ITS2 regions the ribosomal genes. The patient managed medically as surgical approach not...
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Peripheral T cell (PTCL) is a rare and heterogeneous group of non-Hodgkin’s lymphomas with poor prognosis. They constitute real problem given the absence well-codified therapeutic consensus. Aims: The aim our work to describe prognostic aspects PTCLs diagnosed treated in south Tunisia compare results literature data. Methods: Our study retrospective. It concerned patients PTCL excluding Natural Killer followed clinical...
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Peripheral T-cell (PTCL) is a highly heterogeneous invasive non-Hodgkin’s (NHL) originated from mature T cells. PTCL represents 10-15% of NHL patients. The clinical manifestations are variable one entity to another within the PTCL. Aims: aim this study describe characteristics and prognostic factors cohort patients with nodal in south Tunisia. Methods: Our retrospective, it involved treated hematology department Sfax between...
Topic: 2. Acute lymphoblastic leukemia - Clinical Background: T-cell acute (T-ALL) accounts for approximately 12–15% of newly diagnosed ALL cases. Due to intensive therapy, outcomes in T-ALL are steadily improving with 5-year event-free survival (EFS) reaching more than 80%. is thought have distinctive features Tunisian children and young adults. The analysis allowed a better study their characteristics as well evolution after treatment. Aims: aim this was determine the clinical biological...