This study aims to evaluate markers of oxidative stress in Tunisian asthmatic patients and investigate whether their are correlated with uncontrolled asthma. prospective cohort was conducted on 48 healthy subjects 60 asthma (34 controlled 26 asthma). The levels malondialdehyde (MDA), advanced oxidation protein products (AOPP), glutathione (GSH), as well the activities peroxidase (GPx) superoxide dismutase (SOD), were estimated plasma by spectrophotometry. Asthmatic have significantly higher...

The aim of this study was to examine the effect running exercise modality on oxidative stress. Thirteen endurance athletes (age: 21.46 ± 0.66 years) performed three different modalities (Continuous (CR): continuous at 75% VO2max for 25 min; intermittent #1 (15/15): protocol, 15 s VO2max, passive recovery, 50 #2 (30/30): 30 min) in a randomized order. Blood samples were drawn rest and immediately after each assessed malondialdehyde (MDA), advanced oxidation protein products (AOPP), superoxide...

The P-glycoprotein (P-gp) is one of the mechanisms Imatinib (IM) resistance in chronic myeloid leukemia (CML). P-gp has been identified as an efflux pump involved releasing IM outside CML cells. To date, involvement development was not completely understood. Therefore, present study aimed at measuring expression level on lymphocytes from Tunisian patients with and correlating this a molecular response to IM.The peripheral blood 59 (27 responder vs 32 non-responder patients) evaluated by flow...

Background The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence TAC trough levels status in Tunisian KT patients during post-transplantation period (PTP).

Background. Methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy, but it associated with serious toxicities in considerable number patients.Objectives. The aim the current study was to determine which variables were MTX toxicity children, adolescents and young adults ALL.Material Methods. In this prospective study, 35 patients newly diagnosed ALL, treated according 58951 European Organization for Research Treatment Cancer – Children’s Leukemia Group (EORTC-CLG)...

An optimal recovery between training sessions is of similar if not greater importance as the content and program training, itself. One most used strategies for improving ingestion supplements. The present study aimed to evaluate effect 5 mg oral melatonin supplementation on from repeated sprint (RSA) performance biochemical responses (i.e. oxidative stress, leukocytosis cellular damage) after an intensive camp (TC). Twenty soccer players performed RSA test before six-day TC associated with...

Antioxidant supplementation has become a common practice among athletes to boost sport achievement. Likewise, melatonin (MEL) been ingested as an ergogenic aid improve physical performance. To date, no study checked whether the multiple beneficial effects of MEL have outcome during maximum running exercise until exhaustion. Therefore, present aimed evaluate effect ingestion on performance and biochemical responses (i.e., oxidative stress) exhaustive exercise. In double blind randomized...

Melatonin has been proved to have positive effects on cellular damage and metabolic regulation. The aim of the study was determine effect melatonin supplementation during an intensive training period physical performance decline, oxidative stress state. investigation conducted 20 soccer players who participated in exhaustive six-day schedule associated with daily 5 mg oral or placebo ingestion. Resting blood samples were measured before after period. mixed 2-way ANOVA (group x camp) showed...

Chronic urticaria is one of the most frequent skin diseases in medical practice. Urticaria defined as acute if whealing persists for less than six weeks and chronic it longer. that lasts several years to decades significantly impairs quality life. There evidence Helicobacter pylori has a critical role different extragastric such urticaria. We present case an adult patient with H. infection disease regression after triple anti-H. therapy. In contrast autoimmune mechanisms involved against...

It is well established that intensive physical training induces oxidative stress and muscle damage can contribute to fatigue injuries. Melatonin (MEL) has been used as an ergogenic aid (i.e. antioxidant, chronobiotic, anti-inflammatory) which could help athletes during period. The present study aimed evaluate the effect of MEL supplementation on recovery performance, pain biochemical responses after camp (TC). Twenty soccer players, volunteered participate in this study, performed a repeated...

The aim of the present study was to evaluate in patients with acute lymphoblastic leukemia (ALL), oxidative status and antioxidant defense its involvement relapse ALL. plasmatic levels malondialdehyde, advanced oxidation protein products reduced glutathione (GSH), activities catalase, superoxide dismutase (SOD), peroxidase were determined 34 who newly diagnosed ALL compared 92 healthy individuals. concentrations malondialdehyde higher than controls increased during chemotherapy. A decrease...

The aim of this study was to analyse cytoprotective effect polysaccharides compound from Opuntia stricta (O. stricta) cladode (POS) in vitro including its radical scavenging activities and protective effects against hypercholesterolaemia. Our results showed that glucose the dominant monosaccharides (30.35%). Arabinose, pyranose, fructose, galactose, glucose, sorbitol, S-inositol, M-inositol, trehalose saccharose found species. O. did not cause any cytotoxic on HepG2 cells within range...

The current study aimed to examine the effects of caffeine consumption on physical and cognitive performance after an endurance race following one night sleep deprivation. Ten recreational runners performed four test sessions in a randomized order at 09:00 h placebo or 5 mg/kg ingestion during baseline (BN) (bedtime: from 22:30 07:00 h) total deprivation (TSD) (26 hours continuous wakefulness). At each session, they completed 8-km running competition around 400 m outdoor athletics track,...

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms, mainly the C677T, have been implicated as risk factors for several cancers acute lymphoblastic leukemia (ALL). In addition, a potential effect of such variant on efficacy methotrexate (MTX) has reported.In this study, we evaluated impact C677T MTHFR MTX-related toxicity in ALL patients from Tunisia; to provide new insights personalized therapy based human genotype.Genotyping was carried out with restriction fragment length...

Abstract Background This work aimed to evaluate oxidative stress in chronic myeloid leukemia (CML) patients treated with tunisian (IM) vs controls and CML resistance IM without IM. Methods The study included 40 34 controls. Of CML, 26 were developed oxidant/antioxidant markers evaluated by spectrophotometric methods for all used samples. Results For patients, increased malondialdehyde (MDA) advanced oxidation protein products (AOPP) levels found compared ( P < .001; = .01). Higher...

Background: While the promotion of beneficial effects melatonin (MEL) ingestion on modulation oxidative stress is widespread, less attention given to biological influence that it could exert results hematology and clinical chemistry parameters. This study was undertaken assess acute MEL these parameters during a maximal running exercise. Methods: In double blind randomized design, 12 professional soccer players [age: 17.54 ± 0.78 yrs, body mass: 70.31 3.86 kg, height: 1.8 0.08 m; aerobic...

To validate a simplified vancomycin monitoring algorithm in patients on chronic hemodialysis who required intravenous for at least 3 weeks.In this prospective study, all were admitted between April 1, 2013, and March 31, 2015, our unit suspected or confirmed methicillin-resistant <italic>Staphylococcus aureus </italic>infection that enrolled. All categorized into two groups. In group 1 (standard dosing algorithm), the maintenance doses of adjusted according to pre-hemodialysis concentrations...