A5043176257- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Organ Transplantation Techniques and Outcomes
- Respiratory viral infections research
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- Polyomavirus and related diseases
- Circular RNAs in diseases
- Renal Transplantation Outcomes and Treatments
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Cystic Fibrosis Research Advances
- Electroconvulsive Therapy Studies
- vaccines and immunoinformatics approaches
- Takotsubo Cardiomyopathy and Associated Phenomena
- Reproductive System and Pregnancy
Royal Prince Alfred Hospital
2021-2025
The University of Sydney
2024-2025
University Health Network
2020-2024
Peter MacCallum Cancer Centre
2022
Université de Montréal
2022
University of Toronto
2021-2022
The University of Melbourne
2022
Royal Adelaide Hospital
2018-2019
Central Adelaide Local Health Network
2019
Flinders Medical Centre
2019
Solid organ transplant recipients are at high risk of severe disease from COVID-19. We assessed the immunogenicity mRNA-1273 vaccine using a combination antibody testing, surrogate neutralization assays, and T cell assays. Patients were immunized with two doses after each dose above tests. CD4+ CD8+ responses in subset flow-cytometry. A total 127 patients enrolled which 110 provided serum all time points. positive anti-RBD was seen 5.0% one 34.5% doses. Neutralizing present 26.9%. Of note,...
Data regarding coronavirus disease 2019 (COVID-19) outcomes in solid organ transplant recipients (SOTr) across severe acute respiratory syndrome 2 (SARS-CoV-2) waves, including the impact of different measures, are lacking. This cohort study, conducted from March 2020 to May 2023 Toronto, Canada, aimed analyze COVID-19 1975 SOTr various SARS-CoV-2 waves and assess preventive treatment measures. The primary outcome was COVID-19, defined as requiring supplemental oxygen, with secondary...
Background. Solid organ transplant recipients face an increased risk of severe coronavirus disease 2019 (COVID-19) and are vulnerable to repeat acute respiratory syndrome 2 (SARS-CoV-2) infections. In nonimmunocompromised individuals, SARS-CoV-2 reinfections milder likely because cross-protective immunity. We sought determine whether reinfection exhibits manifestations than primary infection in recipients. Methods. Using a large, prospective cohort adult patients with COVID-19, we identified...
Abstract Introduction Carbapenemase‐producing Enterobacterales (CPE) are associated with increased morbidity and mortality in liver transplant recipients (LTRs). There is a paucity of data regarding CPE colonization infection Australian LTRs. Methods A single‐center retrospective cohort study was performed LTRs from 2015 to 2024. underwent targeted screening period enhanced evaluate the incidence colonization. infections were identified via clinical samples. All isolates whole genome...
Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). Vaccination may mitigate this risk; however, immunogenicity appears to be significantly impaired, with reports of increased breakthrough infection. It is unknown if vaccine infections milder or as severe in unvaccinated patients.
<h3>Background:</h3> Severe COVID-19 appears to disproportionately affect people who are immunocompromised, although Canadian data in this context limited. We sought determine factors associated with severe outcomes among recipients of organ transplants across Canada. <h3>Methods:</h3> performed a multicentre, prospective cohort study all solid from 9 transplant programs Canada received diagnosis March 2020 November 2021. Data were analyzed risk for oxygen requirement and other metrics...
Abstract Immunocompromised patients are predisposed to severe COVID-19. Here we compare homotypic and heterotypic humoral cellular immune responses Omicron BA.1 in organ transplant across a diverse clinical spectrum. We perform variant-specific pseudovirus neutralization assays for D614G, Omicron-BA.1, -BA.2, Delta variants. also measure poly-and monofunctional T-cell ancestral SARS-CoV-2 peptide pools. identify that partially or fully-vaccinated recipients after infection with have the...
Normothermic machine perfusion permits the ex vivo preservation of human livers before transplantation. Long-term for days-to-weeks provides opportunity enhanced pretransplant assessment and potential regeneration organs. However, this risks microbial contamination infection recipient if organ is transplanted. An understanding perfusate required to inform control procedures antimicrobial prophylaxis technology.We modified a liver long-term use by adding oxygenators dialysis filter. Human...
Background. Several studies have described the clinical features of COVID-19 in solid-organ transplant recipients. However, many been retrospective or limited to more severe cases (hospitalized) and not routinely included serial virological sampling (especially outpatients) immunologic assessment. Methods. Transplant patients diagnosed with based on a respiratory sample PCR were prospectively followed up 90 d. Patients provided consent for convalescent serum samples nasopharyngeal swabs...
Solid organ transplantation (SOT) has suffered since the beginning of COVID-19 pandemic, chiefly through a reduction in transplant activity and high mortality SARS-CoV-2–infected SOT candidates recipients.1 It was inferred that infection immediately after acquired from an infected donor would have rates higher than 5% to 50% reported unvaccinated recipients at various durations posttransplant.1 In effort reduce likelihood donor-derived infection, initial policy most jurisdictions routine...
Common respiratory viral infections (CRVIs) frequently complicate hematopoietic stem cell transplantation (HSCT). We conducted a retrospective, single-center, observational cohort study to determine the incidence of CRVI in patients who received an allogeneic (allo) or autologous (auto) HSCT at Royal Adelaide Hospital between 2009 and 2017. The median follow-up was 8.9 4.5 years for auto- allo-HSCT recipients, respectively. There were 149 episodes 74 patients, with rhinovirus being most...
T-cell immunity associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination in solid organ transplant recipients (SOTRs) is poorly understood. To address this, we measured responses 50 SOTRs prior SARS-CoV-2 infection. The majority of patients mounted SARS-CoV-2-specific CD4+ against spike (S), nucleocapsid, and membrane proteins; CD8+ were generated to a lesser extent. correlated antibody levels. Severity disease mycophenolate dose moderately lower...
Abstract Background Lung transplant recipients are at increased risk of candidemia, especially in the early posttransplant period. However, specific predisposing factors have not been established. The natural history candidemia after lung transplantation, absence universal antifungal prophylaxis, is known. Methods We retrospectively examined epidemiology any time patients who underwent transplantation our center between 2016 and 2019. undertook a case‐control study used logistic regression...
A 32-year-old female with advanced human immunodeficiency virus infection presented to an Australian hospital subacute, worsening symptoms of encephalitis. Metagenomic sequencing and Dengue NS3 antigen staining brain tissue confirmed active dengue (DENV) The most recent possible DENV exposure was months prior in West Africa, indicating chronicity.
Background: The incidence of invasive fungal infections is increasing in immune-competent and immune-compromised patients. An examination the recent literature related to treatment was performed address two clinical questions. First, patients with proven or probable pulmonary aspergillosis, should combination therapy a mold-active triazole plus echinocandin be administered vs. monotherapy? Second, critically ill at risk for candidiasis who are non-neutropenic not transplant recipients,...
The emergence of coronavirus disease 19 (COVID-19) has significantly disrupted liver transplantation worldwide. Despite significant, collective experience in treating transplant recipients with COVID-19, there remains a paucity data to guide the management candidates acute COVID-19 who require urgent transplantation. We present case an otherwise well, 39-year-old female presenting for failure secondary hepatitis B, concomitant acute, mild due Omicron BA.2. antivirals were not administered...