A5103117170- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Tracheal and airway disorders
- Polyomavirus and related diseases
- Cystic Fibrosis Research Advances
- Mechanical Circulatory Support Devices
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ and Tissue Transplantation Research
- Infectious Diseases and Mycology
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Vascular Anomalies and Treatments
- Palliative Care and End-of-Life Issues
- Adrenal and Paraganglionic Tumors
- Cytomegalovirus and herpesvirus research
- Trauma Management and Diagnosis
- Patient-Provider Communication in Healthcare
- Drug Transport and Resistance Mechanisms
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Anesthesia and Pain Management
Centre Hospitalier de l’Université de Montréal
2014-2025
Canadian Lung Association
2024
Université de Montréal
2013-2023
May Institute
2022
The University of Melbourne
2022
Peter MacCallum Cancer Centre
2022
Royal Prince Alfred Hospital
2022
McGill University
2016
Hôpital Notre-Dame
2003-2014
St. Michael's Hospital
2010
Cyp3A5 activity varies within any given ethnic population, suggesting that genetic variation the gene may be most important contributor to interindividual and interracial differences in Cyp3A-dependent drug clearance response. The full extent of polymorphism a white an indigenous African population was analyzed using DNA direct sequencing procedures. presence 10 12 single nucleotide polymorphisms detected samples, respectively. Thirteen novel mutations occurring at low frequencies were...
Objective The immunosuppressive drug tacrolimus requires strict therapeutic monitoring due to its narrow index and great inter-individual variability. Cytochrome P450 3A4 (Cyp3A4) Cyp3A5 are the most important contributors metabolism while P-glycoprotein pump (MDR-1) modulates bioavailability. objective was investigate association between Cyp3A4, Cyp3A5, MDR-1 polymorphisms pharmacokinetics in early period after renal transplantation. Methods Forty-four transplant recipients were genotyped...
<h3>Background:</h3> Severe COVID-19 appears to disproportionately affect people who are immunocompromised, although Canadian data in this context limited. We sought determine factors associated with severe outcomes among recipients of organ transplants across Canada. <h3>Methods:</h3> performed a multicentre, prospective cohort study all solid from 9 transplant programs Canada received diagnosis March 2020 November 2021. Data were analyzed risk for oxygen requirement and other metrics...
Pheochromocytomas (PCCs) and paragangliomas (PGLs) (PPGLs) are rare tumours arising from the chromaffin cells. There is evidence suggesting a link between hypoxemia PPGLs. Chronic hypoxia can lead to gain of function somatic variants in EPAS1 gene that encodes for hypoxia-inducible factor 2-alpha (HIF-2α), involved PPGL tumorigenesis. To describe case PCC pulmonary transplant patient characterize tumour's genetic background. A 47 year-old man underwent lung chronic obstructive disease...
ABSTRACT Background Mycobacterium abscessus complex is known to cause life‐threatening disease in lung transplantation (LT) recipients (LTRs). Therefore, many centers consider the presence of M. as a relative contraindication LT. Methods We conducted multicenter retrospective cohort study including all 4 LT Canada. All LTRs transplanted 2006–2016 with at least one respiratory sample positive for prior or posttransplantation were included. Pulmonary was defined using American Thoracic Society...
The airway mucosal microenvironment is crucial for host defense against inhaled pathogens but remains poorly understood. We report here that the surface normally undergoes surprisingly large excursions in pH during breathing can reach 9.0 inhalation, making it most alkaline fluid body. Transient alkalinization requires luminal bicarbonate and membrane-bound carbonic anhydrase 12 (CA12) antimicrobial. Luminal concentration CA12 expression are both reduced cystic fibrosis (CF), mucus...
This study aimed to preliminary test the effectiveness of 12-week virtual physical prehabilitation program followed by a maintenance phase. The main objective was estimate extent which it affects exercise capacity, frailty, lower limb strength and health-related quality life (HRQOL) in lung transplant candidates. offered supervised strengthening exercises, independent aerobic exercises weekly phone calls (maintenance phase). Primary outcome six-minute walk distance (6MWD). Secondary...
Chronic immunosuppression in organ transplant recipients predisposes to the development of malignant disease. The authors describe their 29-year institutional experience bronchogenic carcinoma developing after heart and lung transplantation. Seven cases were diagnosed 1,119 recipients. Computed tomography scans radiographs at time diagnosis, as well prior available six patients retrospectively analyzed by two radiologists consensus. seven involved one Six smokers with a mean smoking history...
Obesity and underweight are associated with a higher postlung transplantation (LTx) mortality. This study aims to assess the impact of changes in body mass index (BMI) during waiting period for LTx on early postoperative outcomes.Medical records 502 consecutive cases performed at our institution between 1999 2015 were reviewed. Patients stratified per change BMI category pre-LTx assessment (candidate BMI) transplant as follows: A-candidate BMI, less than 18.5 or 29.9 18.5; B-candidate 29.9;...
Most adults with cystic fibrosis are eventually required to make a decision about referral for lung transplantation.To identify the decisional needs of these patients and develop aid address needs.A comprehensive review literature, Canadian transplant statistics from 2002 2006, self-assessment survey who had already made were performed patients. A was then developed evaluated by an expert panel health care professionals patients.Transplant patterns vary widely among clinics. not residing in...
Context Most adults with cystic fibrosis are eventually required to make a decision about referral for lung transplantation. Objective To identify the decisional needs of these patients and develop aid address needs. Methods A comprehensive review literature, Canadian transplant statistics from 2002 2006, self-assessment survey who had already made were performed patients. was then developed evaluated by an expert panel health care professionals Results Transplant patterns vary widely among...
Differentiating between acute rejection and cytomegalovirus (CMV) infection is one of the major challenges lung transplantation. The aims this study were to: (1) quantify transcription cytotoxic T lymphocyte (CTL) effector molecules in bronchoalveolar lavage (BAL) transplant recipients (2) evaluate clinical usefulness technique.Sixty-six single-lung, double-lung, or heart-lung patients prospectively enrolled study. BAL was performed either for routine surveillance graft dysfunction. RNA...
Abstract Good outcomes with kidney and liver transplantation in HIV‐positive patients have led clinicians to recommend lung based on extrapolated data. Pre‐transplant mycobacterial infection is associated an increased risk of developing new or aggravating existing infection, though it does not contraindicate non‐HIV–infected patients. However, no data exists regarding the outcome pre‐transplant infection. We report a case double 50‐year‐old patient alpha‐1 antitrypsin deficiency. Prior...