A5030962227- Cardiac Arrest and Resuscitation
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Traumatic Brain Injury Research
- Dietary Effects on Health
- Dialysis and Renal Disease Management
- Cardiac pacing and defibrillation studies
- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Orthopedic Infections and Treatments
- Gastroesophageal reflux and treatments
- Congenital gastrointestinal and neural anomalies
- Cardiac electrophysiology and arrhythmias
- Pharmacological Effects and Toxicity Studies
- Pharmacology and Obesity Treatment
- Heart Failure Treatment and Management
- Pharmacogenetics and Drug Metabolism
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Helicobacter pylori-related gastroenterology studies
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
University of Michigan
2022-2025
Flow Analysis (United States)
2025
Stanford University
2024
Abstract Obesity significantly influences drug pharmacokinetics (PK), which challenges optimal dosing. This study examines the effects of diet‐and‐exercise‐induced weight loss on key drug‐metabolizing enzymes and gastric emptying in patients with obesity, who frequently require medications for comorbidities. Participants followed a structured management program promoting over 3–6 months were not concomitantly potential CYP inducers or inhibitors. Using cocktail acetaminophen, caffeine,...
Abstract Background Soluble guanylate cyclase (sGC) stimulators have been investigated for heart failure (HF) in several randomized controlled trials (RCTs). However, its place the management guidelines of either HFrEF or HfpEF is still inconclusive. Methods We conducted a network meta-analysis synthesizing RCTs investigating sGC HF management, which were retrieved by systematically searching five databases until January 24th, 2023. Dichotomous outcomes pooled using risk ratio (RR) along...
The use of race in medicine can contribute to health inequity. Updated equations for estimated glomerular filtration rate (eGFR) without have been published. Likewise, de-indexation eGFR body surface area (BSA) has recommended by regulatory guidance drug dosing renal impairment. Clinical data justifying these recommendations are sparse. We examined the gain or loss precision with creatinine clearance (eCLcr) and using serum (eGFRcr) BSA indexation evaluating population pharmacokinetics...
Abstract Background Metronidazole (MET) is administered on a fixed-dose basis irrespective of body size in adults but studies suggest that dose adjustment may be needed (PMID: 33969405). This study evaluated plasma and fat tissue pharmacokinetics (PK) MET patients undergoing elective colorectal surgery.Table 1.Patient demographics, size, morphomic pharmacokinetic values by obese group. Data reported as median (5th, 95th percentile) valuesFigure 1.Visual predictive check illustrating observed...