A5076979345- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Erythropoietin and Anemia Treatment
- Neonatal Health and Biochemistry
- Blood groups and transfusion
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neurological and metabolic disorders
- Metabolism, Diabetes, and Cancer
- Kidney Stones and Urolithiasis Treatments
- Dialysis and Renal Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Syncope and Autonomic Disorders
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Microfluidic and Capillary Electrophoresis Applications
University of Missouri
2008-2025
University of Missouri Hospital
2012-2013
Previous studies have shown interference with HbA1c measurement from the 4 most common heterozygous Hb variants (HbAS, HbAE, HbAC, and HbAD) some assay methods. Here we examine analytical 49 different less 7 methods using various method principles.Hb were screened Bio-Rad Variant or II beta thal short program, confirmed by alkaline acid electrophoresis, identified sequence analysis. The Trinity ultra2 boronate affinity high-performance liquid chromatography (HPLC) Roche Tinaquant immunoassay...
Hemoglobin A1c (HbA1c) is an important indicator of risk for complications in patients with diabetes mellitus. Elevated fetal hemoglobin (HbF) levels have been reported to interfere results some HbA1c methods, but it has generally assumed that from boronate-affinity methods are not affected by elevated HbF levels. None the previous studies used International Federation Clinical Chemistry and Laboratory Medicine (IFCC) reference method as comparative method. We, therefore, measured samples...
C-peptide is an equimolar by-product of insulin biosynthesis. It used clinically to assess secretion and differentiate types diabetes. However, the lack standardization across assays limits its broader application. This study aimed examine discrepancies between leading measurement methods in clinical laboratories propose a solution reduce them based on complete traceability chain. Two sets serum samples were distributed 10 manufacturers assays. The first set (A, n=20) was analyzed...
Hemoglobin A1c (HbA1c) is an important index of average glycemia in patients with diabetes mellitus that widely used clinical trials and large-scale epidemiological studies. Previous studies have shown adverse sample storage conditions can cause erroneous HbA1c results. We examined the effect at different temperatures five current methods: Tosoh G7 G8 (Tosoh Bioscience, Inc., South San Francisco, CA) Bio-Rad Variant™ II (Bio-Rad Laboratories, Hercules, (all ion-exchange high-performance...