A5086611777- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Advanced Proteomics Techniques and Applications
- Advanced Glycation End Products research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Organoboron and organosilicon chemistry
- Natural Antidiabetic Agents Studies
- Pharmacological Effects and Toxicity Studies
- Bone health and treatments
- Organometallic Complex Synthesis and Catalysis
- Analytical Chemistry and Chromatography
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Amino Acid Enzymes and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Oxidative Organic Chemistry Reactions
- Protein Interaction Studies and Fluorescence Analysis
- Electron Spin Resonance Studies
- Orthopedic Infections and Treatments
University of Missouri
2013-2025
University of Missouri Hospital
2015-2025
Kyowa Hakko Kirin (Singapore)
2015
Aix-Marseille Université
2012-2014
Centre National de la Recherche Scientifique
2012-2014
Institut de Chimie Radicalaire
2012
Lomonosov Moscow State University
2007-2009
A. N. Nesmeyanov Institute of Organoelement Compounds
2007-2008
Abstract Clinically there is a need for local anesthetics with greater specificity of action on target cells and longer duration. We have synthesized series anesthetic derivatives we call boronicaines in which the aromatic phenyl ring lidocaine was replaced ortho ‐, meta C,C’‐dimethyl ‐ para ‐carborane clusters. The boronicaine were tested their analgesic activity compared using standard procedures mice following plantar injection. compounds differed order: ortho‐ carborane = meta‐ >...
The enhanced precision and selectivity of liquid chromatography-tandem mass spectrometry (LC-MS/MS) makes it an attractive alternative to certain clinical immunoassays. Easily transferrable work flows could help facilitate harmonization ensure high-quality patient care. We aimed evaluate the interlaboratory comparability antibody-free multiplexed insulin C-peptide LC-MS/MS measurements.
C-peptide is an equimolar by-product of insulin biosynthesis. It used clinically to assess secretion and differentiate types diabetes. However, the lack standardization across assays limits its broader application. This study aimed examine discrepancies between leading measurement methods in clinical laboratories propose a solution reduce them based on complete traceability chain. Two sets serum samples were distributed 10 manufacturers assays. The first set (A, n=20) was analyzed...
C-peptide secretion mirrors beta-cell function and has emerged as a valuable clinical biomarker for diabetes mellitus. measurements can provide estimates of insulin secretory capacity, aiding in decision-making differentiation between types. Unfortunately, assays are still not standardized, which may limit their practical use. We have developed an MRM-based LC-MS method that demonstrated accuracy close to our reference method. To develop validate mass spectrometry accurate quantitation...
The palladium-catalyzed Buchwald−Hartwig amination of B-iodocarborane by various azoles and amines is described for the first time. reactions 2-iodo-p-carborane with indole, imidazole, benzimidazole, or carbazole in system Pd(dba)2−BINAP−ButONa dioxane at 100 °C gave 2-p-carboranyl derivatives these high yields together 2-hydroxy-p-carborane as a side product. aromatic same products 60−70% also were accompanied formation hydroxy (up to 30% yields). In special investigation it was shown that...
The palladium-catalyzed amidation of B-iodocarboranes by various amides is described for the first time. reactions 2-iodo-1,12-dicarba-closo-dodecaborane (2-iodo-p-carborane) with acetamide, 2-pyrrolidinone, caprolactam, p-methylbenzamide, and 2-phenylacetamide using system Pd(dba)2/BINAP/NaH (dba = dibenzylideneacetone; BINAP rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl) in dioxane at 100 °C gave 2-p-carboranyl derivatives these good to high yields. Similar...
Abstract A novel route for synthesis of B‐mercaptocarboranes is described. The reaction proceeds through Pd‐catalyzed iodine exchange with the sulfur nucleophile TIPS–SH in mono‐ and diiodinated ortho ‐, meta para ‐carboranes. Self‐assembled monolayers selected on a gold surface were analyzed by X‐ray photoelectron spectroscopy their water contact angles assessed.
A number of monosubstituted n-(triphenylphosphonio)-7,8-dicarba-nido-undecaboranes (2a, n = 1; 2b, 3; 2c, 5; 2d, 9) were prepared via a cross-coupling reaction between the tetrabutylammonium iodo-7,8-dicarba-nido-undecaborates (1a-d) and PPh3 in presence Pd(PPh3)4 catalyst. The substitution rate was found to depend on iodine position carborane cage. Under similar conditions, 5,6-diiodo- (3) 9,11-diiodo-7,8-dicarba-nido-undecaborate (5) anions exclusively yielded monosubstitution products...
For the first time, palladium-catalyzed etheration of 2-iodo-p-carborane with phenolates and alkoxides has been demonstrated. The reactions 2-iodo-1,12-dicarba-closo-dodecaborane (2-iodo-p-carborane) sodium salts phenol, p-cresol, α- β-naphthol, 3-methyl-4-chlorophenol, 3,4-dimethylphenol using Pd(dba)2/BINAP (dba = dibenzylideneacetone; BINAP rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl) system in dioxane at 90 °C afforded corresponding 2-p-carboranyl aryl ethers good to high yields....
Abstract Thermal decomposition of four tertiary N ‐(2‐methylpropyl)‐ ‐(1‐diethylphosphono‐2,2‐dimethylpropyl)‐ ‐oxyl (SG1)‐based alkoxyamines (SG1‐C(Me) 2 ‐C(O)‐OR, R = Me, tBu, Et, H) has been studied at different experimental conditions using 1 H and 31 P NMR spectroscopies. This experiment represents the initiating step methyl methacrylate polymerization. It shown that H‐transfer reaction occurs during three in highly degassed solution, whereas no products are detected SG1‐MAMA...
Site Directed Spin Labeling (SDSL) combined with EPR spectroscopy is a very powerful approach to investigate structural transitions in proteins particular flexible or even disordered ones. Conventional spin labels are based on nitroxide derivatives leading classical 3-line spectra whose spectral shapes indicative of the environment and thus constitute good reporters modifications. However, similarity these precludes probing two regions protein partner simultaneously. To overcome limitation...
A liquid chromatography with mass spectrometry on‐line platform that includes the orthogonal techniques of ion exchange and reversed phase is applied for C‐peptide analysis. Additional improvement achieved by subsequent application cation‐ anion‐exchange purification steps allow isolating components have their isoelectric points in a narrow pH range before final reversed‐phase The utility this approach fractions desired “pI window” profiling complex mixtures discussed.
Electrophilic iodination of the 7,9-dicarba-nido-undecaborate anion with molecular iodine in presence AlCl3 generated a new carborane anion—8-iodo-7,9-dicarba-nido-undecaborate—in excellent yield. The capping HBCl2 yielded previously unknown neutral iodinated carborane, 2-iodo-1,7-dicarba-closo-dodecaborane.
Isotope dilution mass spectrometry (IDMS) is based on a simple and straightforward idea of using an isotope labeled compound as internal standard for quantitation purposes. IDMS now competes with routine quantitative methods such immunoassays (ELISA, RIA) due to its high precision, accuracy robustness. The concept allows protein has been showing great promise in clinical application the last decade. present review contains short description current status proteomics principles absolute...
The cover picture shows a novel route for synthesis of 3-SH-1,2-dicarba-closo-dodecaborane. reaction proceeds through Pd-catalyzed iodine exchange with the sulfur nucleophile TIPS–SH in ortho-carborane. presented method makes available previously inaccessible mono- and di-B-mercaptocarboranes from iodocarboranes. thiolated borane clusters can be applied thiol-based self-assembled monolayers (SAMs) on surfaces such as gold. properties SAMs finely tuned by choice carborane isomer position...
C-peptide assays have been widely used as a measure of insulin secretion to assess pancreatic beta-cell function [1] . High levels may reflect resistance, insulinoma, and kidney disease. A low level is usually present in patients with type 1 diabetes and, under certain circumstances, 2 [2] As biomarker, has several advantages over insulin: (i) the degradation rate body (20-30 minute half-life) slower than that (3 5 half-life), which provides more stable test window within fluctuating beta...
Clinically there is a need for local anesthetics with greater specificity of action and longer duration. We have synthesized series anesthetic derivatives we call boronicaines in which the aromatic, phenyl ring lidocaine was replaced ortho‐, meta‐, dimethyl meta‐ para‐carborane clusters. The boronicaine were tested their analgesic activity compared to using standard procedures mice following plantar injection. compounds differed order: ortho‐carborane = meta‐carborane > derivative. Both...