A5029114770- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Clinical Laboratory Practices and Quality Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bacterial Identification and Susceptibility Testing
- Eating Disorders and Behaviors
- Protein Tyrosine Phosphatases
- Pharmacology and Obesity Treatment
- Adrenal Hormones and Disorders
- Artificial Intelligence in Healthcare
- Immunotherapy and Immune Responses
- Sexual function and dysfunction studies
- Machine Learning in Healthcare
- Psoriasis: Treatment and Pathogenesis
- Inflammatory Biomarkers in Disease Prognosis
- SARS-CoV-2 and COVID-19 Research
- Biomarkers in Disease Mechanisms
- Mosquito-borne diseases and control
- Vitamin C and Antioxidants Research
Kwame Nkrumah University
2024
Kwame Nkrumah University of Science and Technology
2020-2024
University of Energy and Natural Resources
2020-2023
Williams (United States)
2020
Komfo Anokye Teaching Hospital
2020
Korle Bu Teaching Hospital
2020
Health-care professionals in Ghana were among the prioritized high-risk groups to be administered with initial supply of Oxford/AstraZeneca vaccine procured by Government Ghana. This study sought assess and identify determinants COVID-19 short-term side effects health-care workers. A cross-sectional was conducted on 654 Ghanaian healthcare workers between 16th March 5th May 2021. The included registered health settings, who had been vaccinated against consented participate survey....
Acute kidney injury (AKI) is routinely diagnosed by creatinine-based guidelines, which sub-optimal marker after due to renal and non-renal factors. This has necessitated the need for more specific sensitive biomarkers early detection of AKI in at risk patients. prospective cross-sectional study used cell cycle arrest Neutrophil Gelatinase Associated Lipocalin (NGAL) assess among hospitalized patients.We conveniently enrolled 151 in-patients Trauma Specialist Hospital, Winneba Ghana....
The burgeoning prevalence of cardiometabolic disorders, including type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) within Africa is concerning. Machine learning (ML) techniques offer a unique opportunity to leverage data-driven insights construct predictive models for MetS risk, thereby enhancing the implementation personalised prevention strategies. In this work, we employed ML develop pre-MetS among diabetic patients.
Abstract Background The interplay between vitamin D status and inflammatory cytokines in a supposedly sufficient sunshine environment has not well been evaluated. study sought to determine their association. Methods This cross-sectional involved 500 healthy adult blood donors from some selected hospitals Ghana enrolled June November 2016. Venous samples were obtained participants, 25(OH)D, TNF-alpha, IFN-gamma, IL 10 measured using enzyme linked immunosorbent assay (ELISA) technique. Serum...
Vitamin D is a steroid hormone important for the normal functioning of body. It produced through skin exposure to sunlight and from diet. Although Ghana located in tropics where abundant, factors like culture, diet, pigmentation, variation ozone layer, geographical area influence optimization vitamin concentration. imperative evaluate interplay between sunshine exposure, proinflammatory cytokines, mediators metabolism their relationship status three sections among apparent healthy...
Diabetes mellitus, an endocrine disorder, has been implicated in many including hypogonadism men. Given the fact that diabetes mellitus is becoming a fast-growing epidemic and morbidity associated with it more disabling than disease itself. This study sought to assess prevalence of low testosterone levels predictors type 2 patients non-diabetic men district hospital Ghana. hospital-based case-control comprised 150 diabetics healthy A pre-structured questionnaire patient case notes were used...
Background. Rheumatoid arthritis (RA) is one of the frequent chronic, systemic, inflammatory autoimmune disorders with an estimated global prevalence 1%. RA leads to joint destruction and disability if left untreated. Ghana has seen very few studies on RA, little known about disease’s severity related variables. This study sought characterize clinical presentation determine disease associated risk factors among patients in a tertiary hospital Ghana. Methods. cross-sectional was conducted...
Abstract Background Late presentation with advanced HIV disease (LP-AHD) remains a significant challenge to Human Immunodeficiency Virus (HIV) care, contributing increased morbidity, mortality, and healthcare costs. Despite global efforts enhance early diagnosis, considerable proportion of individuals infection are unaware being infected therefore present late for care. For the first time in Ghana, this study assessed prevalence LP-AHD associated factors among people diagnosed (PDWH). Method...
T cell cytokines play important roles in the development and progression of rheumatoid arthritis (RA). Loss Th1/Th2 Th17/Treg balance has been reported several inflammatory autoimmune diseases. However, their role RA within hitherto rare Ghanaian context not explored. Here, we evaluated intracytoplasmic CD4+ cytokine patterns patients Ghana determined relationship with disease activity.This case-control study included 48 newly diagnosed 30 apparent healthy controls from two major hospitals...
The active form of vitamin D has immunomodulatory and anti-inflammatory effect. Vitamin is implicated in pathogenesis rheumatoid arthritis (RA) its deficiency leads to increased inflammation. Moreover, production dependent on concentration calcium, phosphorus, parathyroid hormone (PTH). Cytokines mediates inflammation RA synovium. This study evaluated D, mediators proinflammatory cytokines among patients.
In a comparative experimental cross-sectional study, RNA was extracted from oral swabs and blood samples 25 healthy individuals at the Department of Molecular Medicine, KNUST. by manual AGPC extraction method commercial kits. The quantity (ng/μl) purities (260/280 nm) were measured spectrophotometrically using IMPLEN NanoPhotometer® N60. presence in extracts confirmed 2% agarose gel electrophoresis. Statistical analyses conducted R language.The yield swab modified significantly higher...
Abstract Aim Rheumatoid arthritis (RA) is an autoimmune disease which affects millions of lives globally characterized by chronic inflammation in the joints body. There no known cause for RA; however, genetic predisposition has been associated with its occurrence. The association between and RA reported largely among Caucasians Asians. However, few studies limited data have genome‐wide Africa, especially Ghana. In addition, there heterogeneity that exists geographically different...
Background: T cell chemokines and its receptors play important roles in the development progression of rheumatoid arthritis (RA). Their involvement has been reported inflammatory autoimmune diseases. However, their role RA Ghanaian population not explored. We evaluated intracytoplasmic CD4+ chemokine patients Ghana determined relationship with disease activity. Methods. This case control study included 48 newly diagnosed 30 apparent healthy controls from orthopaedic units Komfo Anokye...
Abstract Breast cancer is increasingly common among young women in Ghana. BCa heterogeneous with unique traits that impact causes, prognostic, and predictive outcomes of patients before after menopause. However, limited evidence exists on differences between premenopausal (YPM) postmenopausal cases This study compared breast tumour characteristics YPM (under 35 years) women. We conducted a prospective cross-sectional involving 140 BCa-diagnosed at the Care Clinic Komfo Anokye Teaching...
<title>Abstract</title> Background Colorectal cancer ranks as the third most diagnosed and second lethal globally. The challenge of early detection, essential for better outcomes, lies in often non-specific or absent symptoms, resulting low diagnosis rates, particularly resource-limited settings. For first time, This study pioneers evaluation diagnostic utility hematological parameters, specifically lymphocyte-monocyte ratio (LMR) hemoglobin-platelet (HPR), pre-operative CRC patients Ghana....
Purpose: This study aimed to determine the analytical performance of ABO and Rh D rapid diagnostic test kits as a substitute for conventional tube method. Design/Methodology/Approach: 161 participants who visited Koforidua Technical University Clinic Laboratory were recruited from August September 2022. The used blood groups participants. concordance rate, kappa analysis Receiver Operating Characteristics (ROC) performed. Findings: strength agreement two methods in detecting type using Kappa...
Abstract Background: Asymptomatic malaria remains a diagnostic challenge and serves as reservoir forinfection transmission leads to in children. This study was therefore conducted assess the sociodemographic clinical determinants of asymptomatic Plasmodium falciparum (Pf) infection among school children low season. Methods: In cross-sectional study, 328 ages 6-14 years were recruited study. status determined using three laboratory method: Rapid Diagnostic Test (RDT), Microscopy Polymerase...
Abstract Background T cell receptors play important roles in the development and progression of rheumatoid arthritis (RA). Their involvement has been reported inflammatory autoimmune diseases. However, their role predicting RA is still under exploration. This study evaluated expression CD183 (CXCR3) on T‐cells other relevant biomarkers for detecting determine relationship with disease activity. Methods unmatched case–control included 48 newly diagnosed patients 30 apparent healthy controls...
Abstract Background T cell cytokines play important roles in the development and progression of rheumatoid arthritis (RA). Loss Th1/Th2 Th17/Treg balance has been reported several inflammatory autoimmune diseases. However, their role RA within Ghanaian context not explored. Here, we evaluated intracytoplasmic CD4 + cytokine patterns patients Ghana determined relationship with disease activity. Methods This case-control study included 48 newly-diagnosed 30 healthy controls from two major...
Abstract Background Gastrointestinal Stromal Tumour is a rare but potentially curable tumour of the gastrointestinal tract accounting for up to 1% all tumours. The discovery Imatinib mesylate, novel tyrosine kinase inhibitor has improved chances even unresectable, recurrent, or metastatic diseases. Methods This study sought document clinical and pathological characteristics GISTs from two tertiary hospitals in Ghana that have undergone immunohistochemistry confirmation between 2014 2021....
Gastrointestinal Stromal Tumour is a rare but potentially curable tumour of the gastrointestinal tract accounting for up to 1% all tumours. The discovery Imatinib mesylate, novel tyrosine kinase inhibitor has improved chances even unresectable, recurrent, or metastatic diseases.This study sought document clinical and pathological characteristics GISTs from two tertiary hospitals in Ghana that have undergone immunohistochemistry confirmation between 2014 2021.The median age subjects was 50...