A5040105126- Genetic and Kidney Cyst Diseases
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Biomedical Research and Pathophysiology
- Hedgehog Signaling Pathway Studies
- Mitochondrial Function and Pathology
- Adenosine and Purinergic Signaling
- Phosphodiesterase function and regulation
- Receptor Mechanisms and Signaling
- Protein Degradation and Inhibitors
Harvard University
2017-2021
VA Boston Healthcare System
2017-2021
Brigham and Women's Hospital
2017-2021
Enhanced mitochondrial function enhances cyst formation in an inherited kidney disease caused by loss of polycystin 2.
Significance The primary cilium, a small organelle essential to normal development, has recently been thrust into the limelight owing its involvement in adult disease states such as cancer, obesity, neurodegeneration, and polycystic kidney disease. Here we developed optical approaches interrogate function of receptors that work through cAMP-PKA signaling within cilium live cells. Our data provide key piece puzzle concerning way which localized cAMP signals regulate Hedgehog pathway, another...
This study presents a mechanism-based receptor-targeted cellular therapy approach to treat breast brain metastasis.