A5054451232- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Nanoparticles: synthesis and applications
- Agricultural Practices and Plant Genetics
- Plant Reproductive Biology
- Graphene and Nanomaterials Applications
- X-ray Diffraction in Crystallography
- Medicinal Plants and Neuroprotection
- Plant Virus Research Studies
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Plant Pathogens and Fungal Diseases
- Essential Oils and Antimicrobial Activity
- Plant and fungal interactions
- Microbial Metabolism and Applications
- Cancer Treatment and Pharmacology
- Nanotechnology research and applications
- Phytochemicals and Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- Metal complexes synthesis and properties
- Plant Pathogens and Resistance
- Chemical synthesis and alkaloids
- Infectious Disease Case Reports and Treatments
- Advances in Cucurbitaceae Research
- Tannin, Tannase and Anticancer Activities
Institute of Medical Sciences
2007-2024
Banaras Hindu University
2007-2024
Royal Marsden NHS Foundation Trust
2019
Indian Institute of Vegetable Research
2014-2015
Indian Institute of Science Bangalore
2013
A green-based approach for the synthesis of silver nanoparticles has gained tremendous attention in biomedical applications. Fungal endophytes have been recognized as a remarkable biological source potential nanodrugs. The present study focuses on fabrication using fungal endophyte Penicillium oxalicum (POAgNPs) associated with leaf Amoora rohituka plant. Sharp UV-visible spectra at 420 nm appeared due to surface plasmon resonance POAgNPs and reduction salt. FT-IR analysis revealed presence...
Fungal endophytes have remarkable potential to produce bioactive compounds with numerous pharmacological significance that are used in various disease management and human welfare. In the current study, a total of eight fungal were isolated from leaf tissue Amoora rohituka, out which ethyl acetate (EA) extract Penicillium oxalicum was found exhibit antioxidant activity against DPPH, nitric oxide, superoxide anion hydroxyl free radicals EC50 values 178.30 ± 1.446, 75.79 0.692, 169.28 0.402...
Fungal endophytes are a putative source of bioactive metabolites that have found significant applications in nanomedicine due to their metabolic versatility. In the present study, an aqueous extract fungal endophyte,
Oroxylum indicum (L.) Kurz, a medicinal plant, shows numerous pharmacological properties which may be attributed to the bioactive compounds produced by O. or due associated endophytes. In present study, leaf of was evaluated for presence fungal endophytes, and antioxidant cytotoxic activities from them. Using culture-dependent approach, eight endophytes belonging five different genera were identified. Two Daldinia eschscholtzii Ectophoma multirostrata have been reported first time plant....
Fungal endophytes are known to be a paragon for producing bioactive compounds with variety of pharmacological importance. The current study aims elucidate the molecular alterations induced by produced fungal endophyte Colletotrichum gloeosporioides in tumor microenvironment human breast cancer cells. GC/MS analysis ethyl acetate (EA) extract C. revealed presence anticancer activity. EA exerted potential plasmid DNA protective activity against hydroxyl radicals Fenton's reagent. cytotoxic...
Endophytic fungi are a well-established reservoir of bioactive compounds that pharmaceutically valuable and therefore, contribute significantly to the biomedical field. The present study aims identify anticancer compound from ethyl acetate extract fungal endophyte, Colletotrichum gloeosporioides associated with leaf medicinal plant Oroxylum indicum. fatty acid amide N-(2-Hydroxyethyl)hexadecanamide (Palmitoylethanolamide; PEA) was identified using antioxidant activity-guided fractionation...
Medicinal and aromatic plants (MAPs) are a rich source of bioactive compounds that immensely important due to their potential use in pharmacological agricultural applications. Here, we have evaluated the antimicrobial activity essential oils (EOs) from three different species Ocimum: O. gratissimum (EO1), tenuiflorum (EO2), sanctum (EO3). The EOs were screened for antibacterial against pathogenic strains Escherichia coli, Enterobacter cloacae methicillin-resistant Staphylococcus aureus...
Fungal endophytes have emerged as a promising source of secondary metabolites with significant potential for various applications in the field biomedicine. The biosynthetic gene clusters endophytic fungi are responsible encoding several enzymes and transcriptional factors that involved biosynthesis metabolites. investigation fungal metabolic at genetic level faces certain challenges, including synthesis appropriate amounts chemicals, loss ability to produce an artificial culture medium....
A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)2(pot)2] (1) [Zn(en)2(pot)2]HBr·CH3OH (2) containing ethylenediamine (en) as secondary ligand were synthesized fully characterized. Upon changing the reaction conditions, Cu(II) complex adopts an octahedral geometry around metal center. The cytotoxic activity of (Kpot·H2O) along with 1 2 tested, their anticancer against MDA-MB-231 human breast cancer cells demonstrated, exhibiting...
Abstract Fungal endophytes have established new paradigms in the area of biomedicine due to their ability produce metabolites pharmacological importance. The present study reports vitro cytotoxic and ovo antiangiogenic activity ethyl acetate (EA) extract Penicillium oxalicum chemical profiling through Gas Chromatography–Mass Spectrometry analysis. Treatment EA P. selected human breast cancer cell lines (MDA‐MB‐231 MCF‐7) leads reduced glucose uptake increased nitric oxide production...
Breast cancer remains a global health burden, and the need for effective therapies is of chief importance. The current study explored
Plants have a great potential to grow while carrying inside them fungi and bacteria known as endophytes.These endophytes produce bioactive molecules which are of immense pharmaceutical importance.In the current study, plants having medicinal properties such Moringa oleifera Withania somnifera were explored for studying endophytic associated with them.Moringa widely their nutritional values.The fungal associations these revealed efficacy in therapeutic field.In strains extracted by incubating...