A5062410282- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- X-ray Diffraction in Crystallography
- Cancer, Stress, Anesthesia, and Immune Response
- Crystallization and Solubility Studies
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Phosphodiesterase function and regulation
- Metal complexes synthesis and properties
- Phytochemical compounds biological activities
- Natural Antidiabetic Agents Studies
- Peptidase Inhibition and Analysis
- Sphingolipid Metabolism and Signaling
- Neuropeptides and Animal Physiology
- Synthesis and Characterization of Heterocyclic Compounds
- Carbon and Quantum Dots Applications
- Enzyme function and inhibition
- ATP Synthase and ATPases Research
- Cancer-related Molecular Pathways
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Cancer Treatment and Pharmacology
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Molecular Sensors and Ion Detection
Banaras Hindu University
2019-2025
Fungal endophytes have remarkable potential to produce bioactive compounds with numerous pharmacological significance that are used in various disease management and human welfare. In the current study, a total of eight fungal were isolated from leaf tissue Amoora rohituka, out which ethyl acetate (EA) extract Penicillium oxalicum was found exhibit antioxidant activity against DPPH, nitric oxide, superoxide anion hydroxyl free radicals EC50 values 178.30 ± 1.446, 75.79 0.692, 169.28 0.402...
Fungal endophytes are known to be a paragon for producing bioactive compounds with variety of pharmacological importance. The current study aims elucidate the molecular alterations induced by produced fungal endophyte Colletotrichum gloeosporioides in tumor microenvironment human breast cancer cells. GC/MS analysis ethyl acetate (EA) extract C. revealed presence anticancer activity. EA exerted potential plasmid DNA protective activity against hydroxyl radicals Fenton's reagent. cytotoxic...
Abstract Nimbolide is a tetranortriterpenoid derived from the leaves and flowers of Azadirachta indica (Neem). It exhibits anticancer activity against variety cancers by modulating various crucial features, including cell proliferation, apoptosis, invasion metastasis. More importantly, cytotoxic effect nimbolide has also been observed T lymphoma, but underlying mechanisms are still unexplored. So far, no study conducted to observe on cancer metabolism. Therefore, present investigation was...
Abstract In the past years, PDE5 has emerged as a promising therapeutic target for many cancers due to its highly upregulated expression. Interestingly, recent in vitro study by our group shown antitumor and chemopotentiating action of sildenafil against T cell lymphoma. Our showed that lower doses (50 μM) cisplatin (0.5 μg/mL) exhibited 4% 23% cytotoxicity HuT78 cells, respectively, which was dramatically increased up 50% when treated with both. Hence, present designed evaluate...
Abstract T cell lymphoma represents an aggressive subgroup of having a poor prognosis. Many factors, including psychological stress, define the onset/progression disease. Although stress can cause several health problems, preclinical and clinical reports regarding its role in cancer have been mixed. Therefore, this study, we sought to determine hormone progression provide mechanistic framework activity. Initially, used cBioportal performed expression analysis genes involved pathways with...