A5068298973- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Cystic Fibrosis Research Advances
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial Peptides and Activities
- Neonatal Respiratory Health Research
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Angiogenesis and VEGF in Cancer
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Proteoglycans and glycosaminoglycans research
- Drug Solubulity and Delivery Systems
- Periodontal Regeneration and Treatments
- Advancements in Transdermal Drug Delivery
- Pneumonia and Respiratory Infections
- Cannabis and Cannabinoid Research
- Proteins in Food Systems
- Machine Learning in Bioinformatics
- biodegradable polymer synthesis and properties
- Lipid Membrane Structure and Behavior
- Collagen: Extraction and Characterization
- Bacillus and Francisella bacterial research
- Photodynamic Therapy Research Studies
University of Campania "Luigi Vanvitelli"
2016-2025
University of Naples Federico II
2010-2013
Semmelweis University
2010
Hungarian Academy of Sciences
2010
Universidade de Santiago de Compostela
2010
Italian Institute of Technology
2009
Due to their excellent in vitro activity against multidrug resistant bacteria, antimicrobial peptides (AMPs) hold promise for treatment of Pseudomonas aeruginosa lung infections cystic fibrosis (CF) sufferers. In this work, poly(lactide- co-glycolide) (PLGA) nanoparticles delivery AMPs deriving from the frog-skin esculentin-1a, namely, Esc(1-21) and Esc(1-21)-1c (Esc peptides), were successfully developed. Improved peptide transport through artificial CF mucus simulated bacterial...
Inhaled siRNA therapy has a unique potential for treatment of severe lung diseases, such as cystic fibrosis (CF). Nevertheless, drug delivery system tackling barriers is mandatory to enhance gene silencing efficacy in the airway epithelium. We recently demonstrated that lipid-polymer hybrid nanoparticles (hNPs), comprising poly(lactic-co-glycolic) acid (PLGA) core and lipid shell dipalmitoyl phosphatidylcholine (DPPC), may assist transport nucleic cargo through mucus-covered human To study...
Inhaled antivirulence drugs are currently considered a promising therapeutic option to treat Pseudomonas aeruginosa lung infections in cystic fibrosis (CF). We have recently shown that the anthelmintic drug niclosamide (NCL) has strong quorum sensing (QS) inhibiting activity against P. and could be repurposed as an drug. In this work, we developed dry powders containing NCL nanoparticles can reconstituted saline solution produce inhalable nanosuspensions. were produced by high-pressure...
Nowadays, the downregulation of genes involved in pathogenesis severe lung diseases through local siRNA delivery appears an interesting therapeutic approach. In this study, we propose novel hybrid lipid-polymer nanoparticles (hNPs) consisting poly(lactic-co-glycolic) acid (PLGA) and dipalmitoyl phosphatidylcholine (DPPC) as inhalation system.A panel DPPC/PLGA hNPs was prepared by emulsion/solvent diffusion fully characterized. A combination model siRNAs against sodium transepithelial channel...
Nowadays, the interest in research towards local administration of drugs via inhalation route is growing as it enables direct targeting lung tissue, at same time reducing systemic side effects. This great significance era nucleic acid therapeutics and personalized medicine for treatment severe diseases. However, success any therapy driven by a delicate interplay factors, such physiochemical profile payload, formulation, device, aerodynamic properties, interaction with fluids. The development...
The development of a vascular network in tissue-engineered constructs is fundamental bottleneck bioregenerative medicine, particularly when the size implant exceeds certain limit given by diffusion lengths and/or if host tissue shows very active metabolism. One approaches to achieve vascularization generating sustained release proangiogenic factors from ischemic site. This work describes formation and characterization hyaluronic acid-chitosan (HA/CS) nanoparticles for delivery two...
The success of any tissue engineering implant relies upon prompt vascularization the cellular construct and, hence, on ability scaffold to broadcast specific activation host endothelium and guide vessel ingrowth. Vascular endothelial growth factor (VEGF) is a potent angiogenic stimulator, if released in controlled manner it may enhance vascularization. Therefore, aim this work was realize with integrated depots able release VEGF rate assess promote angiogenesis. VEGF-loaded...
New blood vessel formation is a critical requirement for treating many vascular and ischemia related diseases, as well tissue engineering applications. Angiogenesis vasculogenesis, in fact, represent crucial processes the functional regeneration of complex tissues through strategies. Several growth factors (GFs) signaling molecules involved vessels have been identified, but their application to clinical setting still strongly limited by extremely short half-life body. To overcome these...
Development of inhalable formulations for delivering peptides to the conductive airways and shielding their interactions with airway barriers, thus enhancing peptide/bacteria interactions, is an important part peptide-based drug development lung applications. Here, we report construction a biocompatible nanosystem where antimicrobial peptide SET-M33 encapsulated within polymeric nanoparticles poly(lactide-co-glycolide) (PLGA) conjugated polyethylene glycol (PEG). This system was conceived...