A5032261900- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Plant Molecular Biology Research
- Invertebrate Immune Response Mechanisms
- MicroRNA in disease regulation
- Physiological and biochemical adaptations
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Pregnancy-related medical research
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- Cancer Mechanisms and Therapy
- Glutathione Transferases and Polymorphisms
Hospital Universitari Sant Joan D'Alacant
2022
Instituto de Neurociencias
2006-2021
Consejo Superior de Investigaciones Científicas
2011-2021
Universitat de Miguel Hernández d'Elx
2013-2020
Body-size constancy and symmetry are signs of developmental stability. Yet, it is unclear exactly how developing animals buffer size variation. Drosophila insulin-like peptide Dilp8 responsive to growth perturbations controls homeostatic mechanisms that coordinately adjust maturation maintain within the normal range. Here we show Lgr3 a receptor. Through use functional adenosine 3',5'-monophosphate assays, defined pair neurons mediate regulation. These have extensive axonal arborizations,...
The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of aggressive cancers. Elucidating how pathway facilitates tumorigenesis by may offer opportunities to develop drugs with fewer side effects than those currently available. Here, using an unbiased vivo chemical genetic screen Drosophila, we identified compounds that inhibit activity proinflammatory enzymes nitric oxide synthase (NOS) lipoxygenase (LOX) as selective suppressors Notch-PI3K/Akt cooperative...
A fundamental as yet incompletely understood feature of Notch signal transduction is a transcriptional shift from repression to activation that depends on chromatin regulation mediated by transcription factor RBP-J and associated cofactors. Incorporation histone variants alter the functional properties are implicated in gene expression. Here, we show depletion variant H2A.Z leads upregulation canonical target genes H2A.Z-chaperone TRRAP/p400/Tip60 complex physically associates with at...
Highlights•PsqL and PsqS variants play distinct roles in gene expression tumorigenesis•PsqS colocalizes with GAF, CBP, ISWI, H3K27ac, Pc at enhancers•PsqS form loops, whereas domains mediate compartmental interactions•PsqS Pc-bound enhancers respond to ecdysone, altering 3D chromatin interactionsSummaryEvidence suggests that Polycomb (Pc) is present loop anchors Drosophila. recruited DNA through interactions the GAGA binding factors GAF Pipsqueak (Psq). Using HiChIP Drosophila cells, we find...
Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that signaling sensing fat sufficiency sexual commitment requires the lipid carrier apolipophorin in cells Sema1a neuroendocrine prothoracic gland (PG). Larvae lacking apolpp or fail to initiate despite accruing sufficient stores, they continue gaining weight until death. Mechanistically, peripheral body-fat levels via apolipophorin/Sema1a axis regulates endocytosis, endoplasmic reticulum...
Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that the prothoracic gland in Drosophila larvae monitors peripheral fat sexual commitment via semaphorin 1a (Sema1a). Larvae with knockdown of Sema1a do not mature, continue to grow excessively. The same phenotype occurs after reducing lipid carrier ApoB/lipophorin body. Super-resolution imaging revealed at weight, an endoplasmic reticulum trafficking signal is released permits protein...
Abstract Children and other vertebrate animals stunted due to malnutrition can compensate for this deficit by resuming growth at a higher-than-normal rate via still ill-defined mechanism. High mortality adverse effects later in life may offset the positive of catch-up growth. Here we report that invertebrate Drosophila melanogaster also experiences following period starvation, relaxin receptor Lgr4 instigates Starved larvae weight loss growing two or more times faster starting maturation...