A5101519935- Analytical Chemistry and Sensors
- Pain Mechanisms and Treatments
- Electrochemical sensors and biosensors
- Botulinum Toxin and Related Neurological Disorders
- Water Quality Monitoring and Analysis
- Advanced Chemical Sensor Technologies
- Laser-Plasma Interactions and Diagnostics
- Nerve injury and regeneration
- Natural Antidiabetic Agents Studies
- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- Nonlinear Dynamics and Pattern Formation
- X-ray Diffraction in Crystallography
- Spectroscopy and Laser Applications
- Laser-Matter Interactions and Applications
- Diabetic Foot Ulcer Assessment and Management
- Advanced Fluorescence Microscopy Techniques
- Lipid metabolism and biosynthesis
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Aldose Reductase and Taurine
- bioluminescence and chemiluminescence research
- Molecular Sensors and Ion Detection
- Microfluidic and Capillary Electrophoresis Applications
- Electrochemical Analysis and Applications
University of Illinois Chicago
2018-2025
All India Institute of Medical Sciences
2021-2024
Birla Institute of Technology and Science, Pilani
2024
Smt. N.H.L. Municipal Medical College
2023
MNR Medical College and Hospital
2023
Latifa Hospital
2023
University of Health Sciences Lahore
2023
GSL Medical College & General Hospital
2023
Kathmandu Medical College Teaching Hospital
2023
Deccan College of Medical Sciences
2023
We evaluated neuropathological abnormalities in sural nerve biopsies from 6 nondiabetic control subjects and 16 age-matched diabetic patients with different syndromes of sensory polyneuropathy (6 chronic painful neuropathy [CPN], 4 newly presenting [NPN], painless associated recurrent neurotrophic foot ulcers [RFU]). Although all but one the features myelinated unmyelinated fiber pathology could be found every patient, certain were clinical characteristics neuropathy. Thus, density was...
A new class of live cell permeant, nontoxic fluoranthene-based fluorescent probe (FLUN-550) having a high Stokes shift in aqueous medium has been discovered. It showed selective staining lipid droplets (LDs, dynamic cytoplasmic organelles) at low concentration without background noise vitro imaging 3T3-L1 preadipocytes, J774 macrophages, MCF7 breast cancer cells, and single-celled, parasitic protozoa Leishmania donovani promastigotes vivo nonparasitic soil nematode C. elegans.
To fulfill the increasing energy demand, photoelectrochemical (PEC) water splitting is an effective approach. For that, it very important to give rise efficient photoelectrodes for PEC reaction as anodic sluggish, and because of that overall efficiency remains obstructed. In this context, In2S3/In2O3 nanopyramids with exposed (111) facets are developed following a simple hydrothermal method. Further, effect Au plasmonic nanoparticles (NPs) on nanopyramid surface investigated. NPs decorated...
We studied the long-term effects of streptozotocin-induced diabetes on tissue-specific cytochrome P450 (CYP) and glutathione-dependent (GSH-dependent) xenobiotic metabolism in rats. In addition, we also effect antidiabetic Momordica charantia (karela) fruit-extract feeding modulation oxidative stress rats with diabetes. Our results have indicated an increase (35–50%) CYP4A-dependent lauric acid hydroxylation liver, kidney, brain diabetic About a two-fold CYP2E-dependent hepatic aniline...
A new type of oxygen sensor is described that based on electronic energy transfer from a donor (whose fluorescence efficiently quenched by molecular oxygen) to an acceptor (which less affected oxygen). We use pyrene as the and perylene acceptor. The emission band shows good overlap with absorption When excited at 320 nm, two-fluorophore system strong 476 where itself nonfluorescent. Although not oxygen, strongly responds because efficiency far exceeds quenching for or pyrelene alone....
Electrophysiological, biochemical, and morphometric observations were made on the peripheral nerves of rats after galactose feeding. Motor nerve conduction velocity was found to be reduced. This associated with an accumulation galactitol in a diminution their myoinositol content. An increased water content fascicular area, taken conjunction probable increase area endoneurial spaces, indicated overhydration nerves. Morphometric myelinated fibre population tibial showed no loss fibres although...
A novel series of light emitting and thermally stable non-aggregating benzannulated quinolines acridines were designed prepared from ketene-S,S-acetal under mild conditions through C–C bond formation. Photophysical electrochemical analyses these bipolar N-heterocyclic compounds revealed intense solvatochromism due to the intramolecular charge-transfer character, exemplary for 9b, which covered PL ranging blue (480 nm) green (501 yellow (562 orange (589 using aprotic solvents varying...
The first dual colorimetric and ratiometric fluorescent probe <bold>NAP-3</bold> for selective visualization of labile iron(<sc>iii</sc>) pools in <italic>Caenorhabditis elegans</italic> is reported.
We discovered a new class of nontoxic, highly fluorogenic and biocompatible probe AFN for selective staining intracellular Lipid Droplets (LDs) in both fixed live human cervical cancer cells (HeLa) 3T3-L1 pre-adipocytes without any background artifacts. The salient features the are its visible excitation maximum, aqueous compatibility, selectivity remarkable stability (for more than week) cells, even better commercially available Nile red.
Endoneurial capillary abnormalities have been assessed quantitatively in sural nerve biopsies from diabetic patients with different syndromes of sensory polyneuropathy: chronic painful neuropathy, newly presenting and painless neuropathy associated neurotrophic foot ulceration. Comparisons were made age-matched nondiabetic control subjects. The groups showed no abnormality density or mean endoneurial area per fascicle. Compared subjects, all had an increase diameter, wall thickness, outer...
Abstract Screening of a chemical library pyranones and their ring transformed fluorophores led to the discovery novel 5,6‐dihydro‐2 H ‐pyrano[3,2‐ g ]indolizine ( DPI ) class luminogen 7, which exhibited unique solution–solid dual emission (SSDE) behavior with an color shift from bright‐green in solution strong red solid state. The AIE mechanism these luminogens revealed well‐defined set noncovalent interactions (CH⋅⋅⋅O CH⋅⋅⋅N) that block motion C 2 ‐flexure leading restriction...
Background/Objectives: Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor strongly implicated in various cancers. In its canonical signaling pathway, Janus kinases (JAKs) phosphorylate STAT3 at the Y705 residue response to cytokines or growth factors, with pY705 serving as key marker oncogenic ac-tivity. Elevated levels correlate poor prognosis, numerous small-molecule inhibitors have been developed block this phosphorylation site. More recently,...