A5046599609- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Biotin and Related Studies
- Chemical Synthesis and Analysis
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Traditional and Medicinal Uses of Annonaceae
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- ATP Synthase and ATPases Research
- Advanced biosensing and bioanalysis techniques
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Lanthanide and Transition Metal Complexes
- Chronic Lymphocytic Leukemia Research
- 3D Printing in Biomedical Research
- Biochemical and Molecular Research
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
- Alkaloids: synthesis and pharmacology
- Berberine and alkaloids research
- bioluminescence and chemiluminescence research
- Advanced Proteomics Techniques and Applications
National Taiwan University
2016-2025
Institute of Chemistry, Academia Sinica
2021-2025
Academia Sinica
2021-2024
National Taiwan University of Science and Technology
2021
National Kaohsiung Marine University
2007
Aptamer-based nanovectors that actively bind to circulating monocytes enhance drug delivery the heart and cancer.
Targeting thymidylate kinase (TMPK) that catalyzes the phosphotransfer reaction for formation of dTDP from dTMP is a new strategy anticancer treatment. This study to understand inhibitory mechanism previously identified human TMPK (hTMPK) inhibitor YMU1 (1a) by molecular docking, isothermal titration calorimetry, and photoaffinity labeling. The dynamics simulation suggests 1a prefers binding at catalytic site hTMPK, whereas hTMPK inhibitors bear pyridino[d]isothiazolone or...
Prolyl hydroxylase domain-containing protein 2 (PHD2) inhibition, which stabilizes hypoxia-inducible factor (HIF)-1α and thus triggers adaptation responses to hypoxia in cells, has become an important therapeutic target. Despite the proven high potency, small-molecule PHD2 inhibitors such as IOX2 may require a nanoformulation for favorable biodistribution reduce off-target toxicity. A liposome formulation improving pharmacokinetics of encapsulated drug while allowing targeted delivery is...
Using a chemical approach to crosslink functionally versatile bioeffectors (such as peptides) native proteins of interest (POI) directly inside living cell is useful toolbox for biologists. However, this goal has not been reached due unsatisfactory chemoselectivity, regioselectivity, and protein selectivity in labeling within cells. Herein, we report the proof concept cytocompatible highly selective photolabeling strategy using tryptophan-specific Ru-TAP complex photocrosslinker. Aside from...
Abstract There is a growing interest in developing paramagnetic nanoparticles as responsive magnetic resonance imaging (MRI) contrast agents, which feature switchable T 1 image of water protons upon biochemical cues for better discerning diseases. However, performing an MRI pragmatically limited by its cost and availability. Hence, facile, routine method measuring the highly desired early‐stage development. This work presents single‐point inversion recovery (IR) nuclear (NMR) that can...
Visualizing liposome release profiles in small animals is important for evaluating the pharmacokinetic influence of vesicles.
Abstract Using a chemical approach to crosslink functionally versatile bioeffectors (such as peptides) native proteins of interest (POI) directly inside living cell is useful toolbox for biologists. However, this goal has not been reached due unsatisfactory chemoselectivity, regioselectivity, and protein-selectivity in in-cellulo protein labeling. Herein we report highly selective photoaffinity labeling (PAL) method using tryptophan-specific Ru-TAP complex photocrosslinker (Trp-tag). Aside...