A5070780970- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholesterol and Lipid Metabolism
- Pancreatitis Pathology and Treatment
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Immune Response and Inflammation
Hasselt University
2022-2023
National MS Center Melsbroek
2022-2023
Abstract Macrophages play major roles in the pathophysiology of various neurological disorders, being involved seemingly opposing processes such as lesion progression and resolution. Yet, molecular mechanisms that drive their harmful benign effector functions remain poorly understood. Here, we demonstrate extracellular vesicles (EVs) secreted by repair‐associated macrophages (RAMs) enhance remyelination ex vivo promoting differentiation oligodendrocyte precursor cells (OPCs). Guided...
The progressive nature of demyelinating diseases lies in the inability central nervous system (CNS) to induce proper remyelination. Recently, we and others demonstrated that a dysregulated innate immune response partially underlies failure CNS Extensive accumulation myelin-derived lipids an process these was found disease-promoting phagocyte phenotype. Hence, restoring ability phagocytes metabolize efflux represents promising strategy promote Here, show ApoA-I mimetic peptide 5A, molecule...
Abstract Macrophages play major roles in the pathophysiology of various neurological disorders, being involved seemingly opposing processes such as lesion progression and resolution. Yet, molecular mechanisms that drive their harmful benign effector functions remain poorly understood. Here, we demonstrate extracellular vesicles (EVs) secreted by repair-associated macrophages (RAMs) enhance remyelination ex vivo promoting differentiation oligodendrocyte precursor cells (OPCs). Guided...