A5062500357- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Circadian rhythm and melatonin
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- Photoreceptor and optogenetics research
- Legume Nitrogen Fixing Symbiosis
- Spaceflight effects on biology
- RNA modifications and cancer
- Plant Parasitism and Resistance
- Genomics and Chromatin Dynamics
- Plant and animal studies
- Photosynthetic Processes and Mechanisms
- Computational Drug Discovery Methods
- Agronomic Practices and Intercropping Systems
- Genetic Mapping and Diversity in Plants and Animals
- Machine Learning in Materials Science
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Protein Degradation and Inhibitors
- Animal Genetics and Reproduction
- MicroRNA in disease regulation
- Microbial Natural Products and Biosynthesis
- Pluripotent Stem Cells Research
- RNA and protein synthesis mechanisms
International Institute of Molecular and Cell Biology
2024-2025
Polish Academy of Sciences
2024
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2024
Cold Spring Harbor Laboratory
2020-2023
Institute of Bioorganic Chemistry, Polish Academy of Sciences
2020
Oklahoma Medical Research Foundation
2018
Strigolactones (SLs) are plant-derived signaling molecules that stimulate the hyphal branching of arbuscular mycorrhizal fungi (AMF), and consequently promote symbiotic interaction between fungus plant. Currently, our knowledge on molecular mechanism SL transport is restricted to Solanaceae family. In family, translocation towards rhizosphere occurs through exodermis via hypodermal passage cells involves a member G subfamily, ATP-binding cassette (ABC) membrane transporters. Most Fabaceae...
The auxin-inducible degradation system in C. elegans allows for spatial and temporal control of protein via heterologous expression a single Arabidopsis thaliana F-box protein, transport inhibitor response 1 (AtTIR1). In this system, exogenous auxin (Indole-3-acetic acid; IAA) enhances the ability AtTIR1 to function as substrate recognition component that adapts engineered degron-tagged proteins endogenous E3 ubiquitin ligases complex [SKR-1/2-CUL-1-F-box (SCF)], targeting them by...
Abstract Background HuR/ELAV1, a ubiquitous RNA-binding protein, belongs to the protein family and is crucial for stabilizing regulating translation of various mRNA targets, influencing gene expression. Elevated HuR levels are associated with multiple disorders, including cancer neurodegenerative diseases. Despite identification small molecule inhibitors targeting HuR, their detailed characterization remains limited. Recently, Eltrombopag, an FDA-approved drug immune thrombocytopenic purpura...
Analysis of patient-derived DNA samples has identified hundreds variants that are likely involved in neuropsychiatric diseases such as autism spectrum disorder (ASD) and schizophrenia (SCZ). While these studies couple behavioral phenotypes to individual genotypes, the number diversity candidate genes implicated disorders highlights fact mechanistic underpinnings largely unknown. Here, we describe a RNAi-based screening platform uses C. elegans screen risk (NRGs) for roles controlling...
Abstract Dense core vesicles (DCVs) can transmit signals by releasing neuropeptides from specialized synaptic regions called active zones. DCVs reach the zone motorized transport through a long axon. A reverse motor frequently interrupts progress taking in opposite direction. “Guided transport” refers to mechanism which outward movements ultimately dominate bring region. After guided transport, alter their interactions with motors and enter “captured” state. The mechanisms of capture are...
Synaptic vesicles (SVs) transmit signals by releasing neurotransmitters from specialized synaptic regions of neurons. In the region, SVs are tightly clustered around small structures called active zones. The motor KIF1A transports outward through axons until they captured in region. This transport must be guided forward direction because it is opposed dynein motor, which causes to reverse multiple times en route. core synapse stability (CSS) system contributes both and capture SVs. We...
microRNAs (miRNAs) are potent regulators of gene expression that function in a variety developmental and physiological processes by dampening the their target genes at post-transcriptional level. In many regulatory networks (GRNs), miRNAs switch-like manner whereby activity elicit transition from one stable pattern to distinct, equally required define nascent cell fate. While importance this capacity clear, we have less an understanding cellular factors mechanisms ensure robustness form...
ABSTRACT The auxin-inducible degradation system in C. elegans allows for spatial and temporal control of protein via heterologous expression a single Arabidopsis thaliana F-box protein, transport inhibitor response 1 ( At TIR1). In this system, exogenous auxin (Indole-3-acetic acid; IAA) enhances the ability TIR1 to function as substrate recognition component that adapts engineered degron-tagged proteins endogenous E3 ubiquitin ligases complex (SKR-1/2-CUL-1-F-box (SCF)), targeting them by...
Abstract Developmental robustness relies on precise control of the timing and order cellular events. In C. elegans , invariant sequence post-embryonic cell fate specification is controlled by oscillatory patterns heterochronic microRNA transcription that are phase-locked with larval molting cycle 1-4 . How these transcriptional generated how dosage unknown. Here we show pulses lin-4 produced two nuclear hormone receptors, NHR-85 NHR-23, whose mammalian orthologs, Rev-Erb ROR, function in...
ABSTRACT microRNAs (miRNAs) are potent regulators of gene expression that function in a variety developmental and physiological processes by dampening the their target genes at post-transcriptional level. In many regulatory networks (GRNs), miRNAs switch-like manner whereby activity elicit transition from one stable pattern to distinct, equally required define nascent cell fate. While importance this capacity clear, we have less an understanding cellular factors mechanisms ensure robustness...
Supplemental Figures and Tables to accompany the manuscript entitled, A C. elegans model for integrating functions of neuropsychiatric risk genes identifies components required normal dendritic morphology
Summary While precise tuning of gene expression levels is critical for most developmental pathways, the mechanisms by which transcriptional output dosage-sensitive molecules established or modulated environment remain poorly understood. Here, we provide a mechanistic framework how conserved transcription factor BLMP-1/Blimp1 operates as pioneer to decompact chromatin near its target loci hours before activation and doing so, regulates both duration amplitude subsequent transcription. This...