A5018272827- Skin and Cellular Biology Research
- Statistical Methods and Inference
- Fibroblast Growth Factor Research
- Education, Psychology, and Social Research
- RNA Research and Splicing
- FOXO transcription factor regulation
- Statistical and Computational Modeling
- Mosquito-borne diseases and control
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Skin Protection and Aging
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Advanced Numerical Analysis Techniques
- Influenza Virus Research Studies
- Acute Myeloid Leukemia Research
- Nuclear Structure and Function
- Viral Infections and Vectors
- Bioinformatics and Genomic Networks
- Bayesian Modeling and Causal Inference
- Sarcoma Diagnosis and Treatment
- Computational Drug Discovery Methods
- Vector-borne infectious diseases
- Gestational Diabetes Research and Management
Medical University of Graz
2013-2021
Masaryk University
2011
Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics large international cohort patients with confirmed TBE using uniform protocol. Patients were recruited eight centers from six European countries between 2010 2017. A detailed description signs symptoms was recorded. The obtained information enabled reliable classification 553 555 patients: 207 (37.3%) had meningitis, 273...
Abstract High-throughput sequencing techniques are increasingly affordable and produce massive amounts of data. Together with other high-throughput technologies, such as microarrays, there an enormous amount resources in databases. The collection these valuable data has been routine for more than a decade. Despite different many experiments share the same goal. For instance, aims RNA-seq studies often coincide those differential gene expression based on microarrays. As such, it would be...
An adverse intrauterine environment can result in permanent changes the physiology of offspring and predispose to diseases adulthood. One such exposure, gestational diabetes mellitus (GDM), has been linked development metabolic disorders cardiovascular disease offspring. Epigenetic variation, including DNA methylation, is recognised as a leading mechanism underpinning fetal programming we hypothesised that this plays key role fetoplacental endothelial dysfunction following exposure GDM....
Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance. SH is morphologically characterized by steatosis, liver cell ballooning, cytoplasmic aggregates termed Mallory-Denk bodies (MDBs), inflammation, fibrosis at late stage. Disturbance the keratin cytoskeleton aggregation keratins (KRTs) essential for MDB formation. We analyzed livers aged Krt18-/- mice that spontaneously developed in majority cases HCC independent sex. Interestingly,...
Backround: Steatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis.17-20-months-old Krt18-/- Krt18+/- mice contrast to wt spontaneously developed lesions closely resembling the morphological spectrum of human as well tumors. The pathologic alterations were more...
The ranking of objects, such as journals, institutions or biological entities, is broadly used to assess the relative quality relevance objects. A multiple performed by a number assessors (humans machines) and inference about nature observed rankings desirable for evaluation, business scientific purposes. assessors' decisions are based on some inherent metric scale depend judgement discriminatory ability, data which we usually do not have access. An indirect approach proposed that allows one...
Abstract Background In Austria paediatric influenza-associated hospitalisations and deaths have never been systematically monitored. We examined the influenza season 2017/18 in terms of hospitalisation mortality Austrian population put results into perspective available data from last 15 years. Methods Cases for children below 18 years were retrospectively collected 12 33 hospitals, respectively. Hospitalisation rates whole estimated, adjusting each catchment area. Two databases queried...
Abstract Background: Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance. SH is morphologically characterized by steatosis, hepatocyte ballooning cytoplasmic protein aggregates termed Mallory-Denk bodies (MDBs). MDBs generally composed misfolded keratin (K) 8, 18 in part p62 ubiquitin. It well established that K critical for MDB formation, thus Ks associated with which one the main preconditions development liver cirrhosis (HCC)....