A5071965816- Malaria Research and Control
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- Invertebrate Immune Response Mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Drug-Induced Hepatotoxicity and Protection
- Bacterial Identification and Susceptibility Testing
- Hepatitis C virus research
- Neonatal Health and Biochemistry
- Biomedical Text Mining and Ontologies
Infectious Diseases Research Collaboration
2016-2021
Texas Tech University Health Sciences Center
2020
Texas Tech University
2020
International Development Research Centre
2020
We assessed Plasmodium falciparum drug resistance markers in parasites collected 2012, 2013, and 2015 at 3 sites Uganda. The prevalence frequency of with mutations putative transporters previously associated to aminoquinolines, but increased sensitivity lumefantrine (pfcrt 76T; pfmdr1 86Y 1246Y), decreased markedly all sites. Antifolate were common, apparent emergence (pfdhfr 164L; pfdhps 581G) high-level resistance. K13 linked artemisinin uncommon did not increase over time. Changing...
<ns4:p>The concept of open data has been gaining traction as a mechanism to increase use, ensure that are preserved over time, and accelerate discovery. While epidemiology sets increasingly deposited in databases repositories, barriers access still remain. <ns4:ext-link xmlns:ns3="http://www.w3.org/1999/xlink" ext-link-type="uri" ns3:href="https://clinepidb.org">ClinEpiDB</ns4:ext-link> was constructed an open-access online resource for clinical epidemiologic studies by leveraging the...
<ns4:p>The concept of open data has been gaining traction as a mechanism to increase use, ensure that are preserved over time, and accelerate discovery. While epidemiology sets increasingly deposited in databases repositories, barriers access still remain. <ns4:ext-link xmlns:ns3="http://www.w3.org/1999/xlink" ext-link-type="uri" ns3:href="https://clinepidb.org">ClinEpiDB</ns4:ext-link> was constructed an open-access online resource for clinical epidemiologic studies by leveraging the...
Abstract Background Rapid diagnostic tests (RDTs) play a key role in malaria case management. The most widely used RDT identifies Plasmodium falciparum based on immunochromatographic recognition of P. histidine-rich protein 2 (PfHRP2). Deletion the paralogous pfhrp2 and pfhrp3 genes leads to false-negative PfHRP2-based RDTs, has been reported infections from South America Africa. However, identification pfhrp2/pfhrp3 deletions usually only failure amplify these using PCR, without...
Abstract Background: Rapid diagnostic tests (RDTs) play a key role in malaria case management. The most widely used RDT identifies Plasmodium falciparum based on immunochromatographic recognition of P. histidine-rich protein 2 (PfHRP2). Deletion the homologous pfhrp2 and pfhrp3 genes leads to false-negative PfHRP2-based RDTs, has been reported from South America Africa. However, identification pfhrp2/pfhrp3 deletions usually only failure amplify these using PCR, without confirmation...
Abstract Background Rapid diagnostic tests (RDTs) play a key role in malaria case management. The most widely used RDT identifies Plasmodium falciparum based on immunochromatographic recognition of P. histidine-rich protein 2 (PfHRP2). Deletion the paralogous pfhrp2 and pfhrp3 genes leads to false-negative PfHRP2-based RDTs, has been reported infections from South America Africa. However, identification pfhrp2/pfhrp3 deletions usually only failure amplify these using PCR, without...