A5001809054- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Natural Language Processing Techniques
- Speech and dialogue systems
- Mechanical Circulatory Support Devices
- Speech Recognition and Synthesis
- Cardiac Valve Diseases and Treatments
- Blood transfusion and management
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Reconstructive Surgery and Microvascular Techniques
- Phonetics and Phonology Research
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Topic Modeling
- Congenital Heart Disease Studies
- Surgical site infection prevention
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Aortic aneurysm repair treatments
- Speech and Audio Processing
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Goethe University Frankfurt
2011-2018
University Hospital Frankfurt
2014-2018
MSB Medical School Berlin
2016-2018
Philipps University of Marburg
2007-2014
Universitätsklinikum Gießen und Marburg
2009-2013
Klinikum Ludwigshafen
2001-2010
Leipzig University
2003
San Diego Cardiac Center
2003
Friedrich-Alexander-Universität Erlangen-Nürnberg
1992-2002
Ericsson (Germany)
1998
We investigated the relationship between factor XIII, fibrinogen, blood coagulation screening tests and postoperative bleeding in 98 patients undergoing cardiopulmonary bypass (CPB) surgery. All received aprotinin. Blood samples were collected preoperatively (T1),after termination of CPB (T2),12 h (T3) 24 (T4) after surgery to determine FXIII activity, platelet count, prothrombin time (PT), activated partial thromboplastin (APTT) D-dimers (DD). Laboratory results correlated with chest tube...
We show how prosody can be used in speech understanding systems. This is demonstrated with the VERBMOBIL to-speech translation system which, to our knowledge, first complete which successfully uses prosodic information linguistic analysis. Prosody by computing probabilities for clause boundaries, accentuation, and different types, of sentence mood each word hypotheses computed recognizer. These guide search Disambiguation already achieved during analysis not a verification hypotheses. So...
This paper presents automatic methods for the segmentation and classification of dialog acts (DA). In VERBMOBIL it is often sufficient to recognize sequence DAs occurring during a between two partners. Since turn can consist one or more successive we conduct in step procedure. First each has be segmented into units which correspond DA second categories have identified. For use polygrams multi-layer perceptrons, using prosodic features. The done with semantic trees polygrams.
Background and Objectives Solvent/detergent‐treated plasma (SDP) contains markedly lower protein S (PS) plasmin inhibitor (PI) activity than standard fresh‐frozen (FFP). It has also been reported that SDP no α 1 ‐antitrypsin. Despite the lack of clinical data, it is suspected may be less effective FFP in treatment complex coagulopathies. We therefore conducted a prospective trial to study impact on haemostasis fibrinolysis coagulopathy after open‐heart surgery. Materials Methods Patients...
The introduction of fast-track treatment procedures following cardiac surgery has significantly shortened hospitalisation times in intensive care units (ICU). Readmission to is generally considered a negative quality criterion. aim this retrospective study statistically analyse risk factors and predictors for re-admission the ICU after patient management program.229 operated patients (67 ± 11 years, 75% male, BMI 27 3, 6/2010-5/2011) with use extracorporeal circulation (70 31 min aortic...
BACKGROUND Nucleic acid–targeted pathogen inactivation technology using amustaline (S‐303) and glutathione (GSH) was developed to reduce the risk of transfusion‐transmitted infectious disease transfusion‐associated graft‐versus‐host with red blood cell (RBC) transfusion. STUDY DESIGN AND METHODS A randomized, double‐blind, controlled study performed assess in vitro characteristics amustaline‐treated RBCs (test) compared conventional (control) evaluate safety efficacy transfusion during after...
Acute kidney injury (AKI) after cardiac surgery procedures is associated with poor patient outcomes. Cystatin C as a marker for renal failure has been shown to be of prognostic value; however, wide range its predictive accuracy reported. The aim the study was evaluate whether measurement pre- and postoperative serum cystatin improves prediction AKI.In single-centre, prospective 70 patients (74 ± 9 ys; 47-85 77% male), measured six times: (T1=preoperative, T2=start cardiopulmonary bypass...
Background: Intraoperative blood salvage is an important part of conservation efforts in cardiac surgery. The purpose this study to examine the effects three different circuit blood-salvaging techniques: centrifugation, ultrafiltration and direct infusion. Methods: Sixty patients undergoing elective coronary bypass graft procedures were randomly assigned a prospective manner one methods. Results: Intra- postoperative samples demonstrated increased hemoglobin values infusion group higher...
Vacuum-assisted closure (VAC) of complex infected wounds has recently gained popularity among various surgical specialties. The system is based on the application negative pressure by controlled suction to wound surface. effectiveness VAC System microcirculation and promotion granulation tissue proliferation are proved. No contraindications for use in deep sternal cardiac surgery described. In our case report we illustrate a scenario were patient developed severe bleeding from ascending...
The growing number of high-risk patients in cardiac surgery unavoidably leads to more complications, and therefore a prolonged stay an intensive care unit (ICU). aim our investigation was elaborate on the fate patents after long-term ICU treatment.Out 5055 patients, 232 had be treated for longer than 5 days ICU. These were analyzed in-hospital mortality followed up quality life. Barthel mobility index geriatric depression scale by Sheikh Yesavage used evaluate physical ability mood...
Patients undergoing cardiac surgery presenting with chronic obstructive pulmonary disease (COPD) have a higher 30-day mortality risk. In these patients, dysfunction linked to an inflammatory response is frequent after operations using cardiopulmonary bypass (CPB), which causes hypoperfusion. We hypothesize that selective perfusion (sPP) of the lungs leads reduction inflammation and better clinical outcome. Fifty-nine COPD patients (forced expiratory volume in 1 s/vital capacity <70%)...
This study was conducted to compare bispectral index, state entropy and response in patients undergoing coronary artery bypass grafting.In 66 patients, anaesthesia maintained at two different levels using index. Doses of sufentanil midazolam were adjusted achieve a index the range 45-55 33 (BIS 50 group) 35-44 another 40 group). Simultaneously, recorded.The targeted values achieved both groups differed significantly during whole anaesthesia. Median fell 19-26 groups. Response only after...
Levosimendan is a calcium-sensitizing drug that enhances myocardial contractility without increasing intracellular calcium. By activating adenosine triphosphate-dependent potassium channels it exerts cardioprotective and vasodilatory effects.A retrospective matched pair analysis was performed in 52 patients undergoing emergency coronary artery bypass grafting for acute ischaemia with or cardiogenic shock. A total of 27 received levosimendan (bolus 6 microg kg(-1); continuous infusion 0.2...
The reduction ascending aortoplasty in patients with an aortic ectasia/dilatation is a common procedure during concomitant cardiac operations. Aim of the follow up study was evaluation possible re-dilatation and complications.From 1998 to 2010 124 (69% male; mean age 66.6 ± 12 ys) ectasia who had no further indication for replacement, were included. preoperative diameter aorta 4.2 0.6 cm. risk profile moderate (mean EF 51% 11%, Euroscore 2.1). To treat dilatation aorta, longitudinal incision...
About 80 % of patients receiving an implantable cardioverter-defibrillator (ICD) due to life-threatening episodes ventricular tachycardia (VT) or fibrillation (VF) have structural heart disease. ICD implantation reduces the risk sudden cardiac death less than 2 %. However, major obstacle in these is chronic failure (CHF). Biventricular stimulation (BIV) has shown its efficiency as alternative therapy drug refractory CHF.According InSync registry, we predefined possible indications for BIV...
We present the prosody module of VERBMOBIL speech-to-speech translation system, world wide first complete which successfully uses prosodic information in linguistic analysis. This is achieved by computing probabilities for clause boundaries, accentuation, and different types sentence mood each word hypotheses computed recognizer. These guide search Disambiguation already during analysis not a verification hypotheses. So far, most useful provided boundaries. are detected with recognition rate...