A5016600882- Cardiac Imaging and Diagnostics
- Galectins and Cancer Biology
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Signaling Pathways in Disease
- Mechanical Circulatory Support Devices
- Cardiovascular Effects of Exercise
- Cardiac Arrest and Resuscitation
- Cancer Immunotherapy and Biomarkers
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- CAR-T cell therapy research
- Advanced X-ray and CT Imaging
- Immunotherapy and Immune Responses
- Cerebrovascular and Carotid Artery Diseases
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
University at Buffalo, State University of New York
2016-2025
Jacobs Institute
2019-2024
Mangalayatan University
2024
Punjab Institute of Medical Sciences
2024
Jacobs (United States)
2020-2024
Canon (United States)
2020-2023
Southern California Clinical and Translational Science Institute
2021
Orlando VA Medical Center
2020
Univar (United States)
2018
Massachusetts General Hospital
2014-2015
Inflammatory mechanisms have been proposed to be important in heart failure (HF), and cytokines implicated add the progression of HF. However, it is unclear whether such are already activated when hypertrophied hearts still appear well-compensated early contribute development HF.In a comprehensive microarray study, galectin-3 emerged as most robustly overexpressed gene failing versus functionally compensated from homozygous transgenic TGRmRen2-27 (Ren-2) rats. Myocardial biopsies obtained at...
Galectin-3 (Gal-3) is secreted by activated macrophages. In hypertension, Gal-3 a marker for hypertrophic hearts prone to develop heart failure. infused in pericardial sac leads cardiac inflammation, remodeling, and dysfunction. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), naturally occurring tetrapeptide, prevents reverses inflammation collagen deposition the hypertension failure postmyocardial infarction. present study, we hypothesize that Ac-SDKP Gal-3-induced dysfunction, these...
Cardiac hypertrophy can lead to heart failure (HF), but it is unpredictable which hypertrophied myocardium will progress HF. We surmised that apart from hypertrophy-related genes, failure-related genes are expressed before the onset of failure, permitting molecular prediction Hearts hypertensive homozygous renin-overexpressing (Ren-2) rats had progressed early HF were compared by microarray analysis Ren-2 remained compensated. To identify HF-related preceded cardiac biopsy specimens taken...
High blood pressure (HBP) is an important risk factor for cardiac, renal, and vascular dysfunction. Excess inflammation the major pathogenic mechanism HBP-induced target organ damage (TOD). N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), a tetrapeptide specifically degraded by angiotensin converting enzyme (ACE), reduces inflammation, fibrosis, TOD induced HBP. Our hypothesis that Ac-SDKP exerts its anti-inflammatory effects inhibiting: 1) differentiation of bone marrow stem cells (BMSC) to macrophages,...
Background Immune checkpoint inhibitors (ICI) have emerged as a front-line therapy for variety of solid tumors. With the widespread use these agents, immune-associated toxicities are increasingly being recognized, including fatal myocarditis. There limited data on outcomes and prognostic utility biomarkers associated with ICI-associated Our objective was to examine associations between clinical cardiomyocyte damage mortality in patients cancer treated ICIs. Methods We retrospectively studied...
The serological hallmark of primary biliary cirrhosis (PBC) is the presence pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AMAs). Anti–PDC-E2 cross-react specifically with mycobacterial hsp65, and we have demonstrated that motif SxGDL[ILV]AE shared by PDC-E2212-226 hsp's a cross-reactive target. Having found this same present only in β-galactosidase Lactobacillus delbrueckii (BGAL LACDE), hypothesized homology would also lead to cross-reactivity. mimics were...
Inflammation contributes to the process of ventricular remodeling after acute myocardial injury. To investigate role macrophages in chronic cardiac remodeling, they were selectively depleted by intravenous administration liposomal clodronate heart failure-prone hypertensive Ren-2 rats from age 7 until 13 weeks. Plain liposomes used for comparison. Liposomal treatment reduced number blood monocytes and decreased myocardium. Compared plain liposomes, rapidly worsened left ejection function...
Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking expression would have an impact on the heart and relationship to simply epiphenomenon. The direct association between myocardial inflammation, dysfunction, adverse cardiovascular outcomes post-MI was examined using clinical translational studies.We performed analysis of 9753 genes...
Background: Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and vitro studies have shown that increased galectin-3 (gal3) expression into the myocardium associated higher incidence of fibrosis. Although elevated gal3 linked myocardial fibrosis, its role predicting risk SCD unknown. Methods: We reviewed clinical datasets post-mortem examination 221 subjects who had died suddenly. examined pathology including extent cardiac...
Myocarditis is a potentially fatal condition, with mortality rate of up to 50% in severe cases. Studies, including those by Nobel Laureate Honjo, have implicated autoantibodies against cardiac troponin I (cTnI) driving inflammation mice. Research has also identified under baseline conditions some cancer models. However, data on the effects recombinant cTnI autoantibody production, myocardial inflammation, and contractile function remain limited. This study investigated cTnI-associated...
Background: Post-cardiac arrest syndrome (PCAS) is characterized by a robust inflammatory response that contributes to significant morbidity and mortality among patients resuscitated from sudden cardiac (SCA). Mitochondrial DNA (mtDNA), with its bacterial-like genomic motifs, has been implicated as damage-associated molecular pattern in other contexts, but role pro-inflammatory stimulus PCAS not studied. Accordingly, the present study was designed determine if rise circulating mtDNA and, so,...
Although increased activity of angiotensin-converting enzyme (ACE) has been associated with cardiac collagen, no studies to date have established a direct cause-and-effect relation between the two.We used transgenic rats that overexpress human ACE selectively in myocardium. Two independent heterozygous rat lines were studied, one expressing 2 3 copies (L1172) and other 5 10 (L1173) transgene. These normotensive but developed proportionate increase myocardial collagen depending on gene dose...
We sought to evaluate the effect of application revised 2010 Task Force Criteria (TFC) on prevalence major and minor Cardiovascular Magnetic Resonance (CMR) criteria for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) versus original 1994 TFC. also assessed utility MRI identify alternative diagnoses patients referred ARVC evaluation. 968 consecutive our institution CMR with clinical suspicion from 1995 2010, were evaluated presence per included right ventricle (RV) dilatation, reduced...
Advances in radiotherapy for thoracic cancers have resulted improvement of survival. However, radiation exposure to the heart can induce cardiotoxicity. No therapy is currently available inhibit these untoward effects. We examined whether a small tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), counteract radiation-induced cardiotoxicity by inhibiting macrophage-dependent inflammatory and fibrotic pathways.After characterizing rat model cardiac irradiation with magnetic resonance imaging...